scholarly journals Nevirapine Associated Stevens Johnson Syndrome in an HIV Positive Pregnant Woman- A Case for Pharmacovigilance.

2020 ◽  
Vol 7 (09) ◽  
pp. 5044-5047
Author(s):  
Akpa MA ◽  
Akogu SPO ◽  
Abba MA
Keyword(s):  
Human Immunodeficiency Virus ◽  
Case Report ◽  
Pregnant Woman ◽  
Health Education ◽  
Stevens Johnson Syndrome ◽  
Hiv Positive ◽  
Drug Reactions ◽  
Johnson Syndrome ◽  
Immunodeficiency Virus ◽  
Pregnant State

This is a case report of a 41 year old multipara with human immunodeficiency virus (HIV) infection with an interesting history. She was initially commenced on a regimen of antiretroviral which included nevirapine in her non pregnant state. A change of drugs to replace nevirapine with efavirenz was instituted when skin rash was noticed. Unfortunately, she was recommenced on nevirapine when she became pregnant at 15 weeks gestation and developed symptoms of Stevens Johnson syndrome necessitating admission and treatment following which she made a full recovery. The presentation of this case highlights the importance of pharmacovigilance and health education to patients about adverse drug reactions.

scholarly journals Clinical Profile of Adverse Cutaenous Drug Reactions in Patients with Human Immunodeficiency Virus

2020 ◽  
Vol 7 (4) ◽  
Author(s):  
Puteri Nabilah Maharani ◽  
Oki Suwarsa ◽  
Susantina Prodjosoewojo
Keyword(s):  
Human Immunodeficiency Virus ◽  
Clinical Features ◽  
Secondary Data ◽  
Stevens Johnson Syndrome ◽  
Clinical Feature ◽  
Drug Reactions ◽  
Hiv Patients ◽  
Increased Risk ◽  
Immunodeficiency Virus ◽  
Cutaneous Drug Reactions

Background: Adverse cutaneous drug reactions (ACDRs) are common problems in patients during the treatment of various diseases. The clinical feature varies from mild manifestation such as morbilliform, urticaria, and contact dermatitis, to severe manifestation such as Stevens - Johnson syndrome (SJS) and Toxic Epidermal Necrolysis (TEN). Patients infected with the human immunodeficiency virus (HIV) have an increased risk of developing ACDRs due to immune system disruption. This study aimed to describe the clinical features of ACDRs in HIV patients and the drugs that cause ACDRs. Method: This study was a retrospective study using secondary data from medical records of HIV patients with ACDRs who visited Teratai Clinic of Dr. Hasan Sadikin General Hospital Bandung from 2014 to 2018. Total sampling was applied and results were presented in percentage. Results: There were 94 HIV patients with ACDRs out of 557 HIV patients. Adverse cutaneous drug reactions are commonly found in males aged 20-39 years old. The clinical features found were morbilliform (85.6%), SJS (8.9%), urticaria (4.4%), and erythroderma (1.1%). The most common drugs causing ACDRs were Cotrimoxazole (30%), Efavirenz (28.9%), and Nevirapine (16.7%). Conclusion: The prevalence of ACDRs in HIV patients in this study is 16.9%. The most common clinical features are morbilli form and SJS with Cotrimoxazole, Efavirenz, and Nevirapine causing most of the ACDRs.

scholarly journals Stevens-Johnson syndrome induced by phenytoin: a case report

2016 ◽  
Vol 6 (1) ◽  
pp. 208
Author(s):  
Lalkota Prakash Bhanu ◽  
Kumara Swamy M. ◽  
Mohammed Nasiruddin ◽  
Naveen H. D. ◽  
Rajesh Venkataraman
Keyword(s):  
Adverse Reaction ◽  
Case Report ◽  
Toxic Epidermal Necrolysis ◽  
Antiepileptic Drugs ◽  
Stevens Johnson Syndrome ◽  
Drug Reactions ◽  
Cutaneous Adverse Reaction ◽  
Johnson Syndrome ◽  
Life Threatening ◽  
Grade 3

Stevens-Johnson syndrome (SJS) and Toxic epidermal necrolysis (TEN) are rare (one to two per 10,00,00 population per year) but life threatening adverse drug reactions. Antiepileptic drugs-induced Stevens-Johnson syndrome (SJS) is a life-threatening severe cutaneous adverse reaction, amongst anti-epileptics; carbamazepine and phenytoin are the major culprits. We report here a case of SJS due to phenytoin (CTC vs 2 Grade 3).

Scrotal ulcer due to community-acquired methicillin-resistant Staphylococcus aureus USA300 clone in an HIV-positive man who has sex with men in Japan: a case report

2019 ◽  
Vol 30 (12) ◽  
pp. 1229-1231 ◽  
Author(s):  
Yoshihiko Ogawa ◽  
Kei Kasahara ◽  
Tomoko Asada ◽  
Shingo Yoshihara ◽  
Nobuyasu Hirai ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Human Immunodeficiency Virus ◽  
Case Report ◽  
Chlamydia Trachomatis ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Hiv Positive ◽  
Sexually Transmitted ◽  
Immunodeficiency Virus ◽  
Usa300 Clone ◽  
Sex With Men

A genital ulcer can be associated with sexually transmitted infections, such as syphilis and herpes, and sexually transmitted organisms, such as Chlamydia trachomatis. We report a case of scrotal ulcer caused by Staphylococcus aureus clone USA300 in a 56-year-old man living with human immunodeficiency virus in Osaka, Japan. It is important to enhance the awareness and surveillance regarding the potential of spread of this organism in the community of men who have sex with men in this district.

scholarly journals Nimesulide induced Stevens Johnson Syndrome: a case report

2017 ◽  
Vol 6 (8) ◽  
pp. 2094
Author(s):  
Shagupta A. Naikwadi ◽  
Rupali B. Jadhav
Keyword(s):  
Case Report ◽  
Supportive Care ◽  
Adverse Drug Reactions ◽  
Stevens Johnson Syndrome ◽  
Drug Reactions ◽  
Over The Counter ◽  
Johnson Syndrome ◽  
Inflammatory Drugs ◽  
Prescribed Medicines ◽  
Possible Cause

Adverse drug reactions to the prescribed medicines are the major obstacles in continuation of drug treatment. Stevens- Johnson Syndrome (SJS) is a severe, episodic, acute mucocutaneous reaction which is most commonly elicited by drugs and occasionally by infections. Common drugs associated with SJS are sulphonamide antibiotics, anticonvulsants, non- steroidal anti-inflammatory drugs (NSAIDS) and allopurinol. Nimesulide is an NSAID with analgesic and antipyretic properties. Here, we report a case of 21 years old male patient who developed Stevens Johnson Syndrome following ingestion of tablet Nimesulide. The patient was managed with parenteral corticosteroids, antibiotics, emollients, and supportive care. This case highlights the importance of Nimesulide and other NSAIDs as possible cause of SJS. Nimesulide has never been approved in countries like USA, Canada, Australia. But in India it is available as over the counter drug and is used for various indications like fever, myalgia, arthralgia. Therefore, the drugs which are banned outside India should be used with caution and practitioners should report all the adverse drug reactions to such drugs.

Primary Infection with Human Immunodeficiency Virus that Presented as Stevens-Johnson Syndrome

1994 ◽  
Vol 19 (4) ◽  
pp. 798-798 ◽  
Author(s):  
E. Mortier ◽  
J. R. Zahar ◽  
I. Gros ◽  
J. P. Vignali ◽  
A. M. Simonpoli ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Primary Infection ◽  
Stevens Johnson Syndrome ◽  
Johnson Syndrome ◽  
Immunodeficiency Virus
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