scholarly journals Henoch Schonlein Purpura in Children: Clinical Profile and Renal Involvement

2018 ◽  
Vol 6 (4) ◽  
Author(s):  
Geetha Peethambaran ◽  
Keyword(s):  
Renal Involvement ◽  
Clinical Profile ◽  
Henoch Schonlein Purpura ◽  
Schonlein Purpura ◽  
Henoch Schönlein Purpura

Clinical profile and outcome of Henoch Schonlein purpura in a tertiary care hospital in South India

2017 ◽  
Vol 4 (3) ◽  
pp. 822 ◽  
Author(s):  
Shanavas Abbas ◽  
Geetha S. ◽  
Deepthi R.V. ◽  
Jubin Kamar ◽  
Susan Uthup
Keyword(s):  
Clinical Features ◽  
Renal Involvement ◽  
Tertiary Care ◽  
Clinical Profile ◽  
Treatment Modalities ◽  
Joint Involvement ◽  
Care Hospital ◽  
Henoch Schonlein Purpura ◽  
Schonlein Purpura ◽  
Henoch Schönlein Purpura

Background: Henoch Schonlein purpura (HSP) is the most common systemic vasculitis in children. It is an immunoglobulin A (IgA) mediated systemic small-vessel vasculitis, with IgA deposition in vessel walls leading to symptoms involving the skin, joints, intestines, and kidneys. The objective of present study was to identify and describe the clinical profile, pattern of joint involvement, histopathological features, treatment modalities and complications of Henoch Schonlein purpura.Methods: 52 children less than 12 years diagnosed to have Henoch Schonlein Purpura according to the European League against Rheumatism criteria were included in the study. All patients were subjected to detailed history taking and thorough examination. The clinical features, investigations, management and complications of the disease were studied. Descriptive statistics was used to analyse the results.Results: The common clinical features were palpable purpura (100%) followed by arthritis (66%) and abdominal pain (50%). Renal manifestations were in the form of hematuria in 12% of the patients. Skin biopsy was done in 25 patients of which 19 had findings suggestive of Henoch Schonlein purpura. Steroids were used in 42% of patients. The severity of illness was associated with lower mean age, arthritis, leg edema and stool occult blood.Conclusions: The clinical features of Henoch Schonlein purpura in the population were different from the previously published studies. Renal involvement was less common. The short-term outcome of the patients were satisfactory. 

scholarly journals Clinical profile and pattern of Henoch-Schönlein purpura in children

2015 ◽  
Vol 2 (1) ◽  
pp. 17-21 ◽  
Author(s):  
Ganesh Shah
Keyword(s):  
Renal Involvement ◽  
Clinical Profile ◽  
Upper Respiratory Tract ◽  
Henoch Schonlein Purpura ◽  
Patients Âgés ◽  
Streptolysin O ◽  
Gastrointestinal Manifestation ◽  
Upper Respiratory ◽  
Schonlein Purpura ◽  
Henoch Schönlein Purpura

Introduction: This study was done to evaluate clinical profile of Henoch- Schönlein purpura (HSP) in children admitted in Patan Hospital.Methods: The medical records of all the children admitted in children ward with diagnosis of HSP from January 2008 to December 2015 were analysed for clinical presentation, management and outcome.Results: Of 59 patients, 37 (63%) were boys. The patients’ ages ranged from 15 months to 14 years with a mean of 8.3 years. Approximately, two third cases presented during winter and autumn. Upper respiratory tract infection preceded HSP in 37 and anti streptolysin O titer was positive in 6 of the 13 (46%) children tested at presentation. Skin purpura was seen in 59 (100%), arthritis or arthralgia in 48 (81%), gastrointestinal manifestation in 47 (80%) and renal involvement in 16 (27%). Forty-one (69%) patients received corticosteroid therapy. All the children made a full recovery, two with nephritis continued to have hypertension, hematuria and proteinuria. Symptoms occurred in 6 (10%) over a period one month to two years follow up.Conclusions: The HSP in children had seasonal occurrence, skin rash, pain abdomen with mild diseases and recovered well. Journal of Patan Academy of Health Sciences, Vol. 2, No. 1, 2015. page:17-21

scholarly journals 119 Location of skin lesions in Henoch-Schonlein purpura (HSP) and its association with renal involvement

2016 ◽  
Vol 136 (5) ◽  
pp. S22
Author(s):  
J. St. John ◽  
A. Garza-Mayers ◽  
P. Vedak ◽  
M. Hoang ◽  
S. Nigwekar ◽  
...  
Keyword(s):  
Renal Involvement ◽  
Skin Lesions ◽  
Henoch Schonlein Purpura ◽  
Schonlein Purpura ◽  
Henoch Schönlein Purpura

Location of skin lesions in Henoch-Schönlein purpura and its association with significant renal involvement

2018 ◽  
Vol 78 (1) ◽  
pp. 115-120 ◽  
Author(s):  
Jessica St. John ◽  
Priyanka Vedak ◽  
Anna Cristina Garza-Mayers ◽  
Mai P. Hoang ◽  
Sagar U. Nigwekar ◽  
...  
Keyword(s):  
Renal Involvement ◽  
Skin Lesions ◽  
Henoch Schonlein Purpura ◽  
Schonlein Purpura ◽  
Henoch Schönlein Purpura

scholarly journals Neutrophil-to-lymphocyte Ratio: A Biomarker for Predicting Systemic Involvement in Henoch–Schonlein Purpura

2021 ◽  
Vol 0 ◽  
pp. 1-4
Author(s):  
Wang Lei ◽  
Shan Yun-Yun ◽  
Xu Ai-E
Keyword(s):  
Inflammatory Marker ◽  
Renal Involvement ◽  
Neutrophil To Lymphocyte Ratio ◽  
Henoch Schonlein Purpura ◽  
Systemic Involvement ◽  
Lymphocyte Ratio ◽  
Number Of Patients ◽  
Pre Treatment ◽  
Schonlein Purpura ◽  
Henoch Schönlein Purpura

Background: Henoch–Schonlein purpura (HSP) is one of the commonest entities included within the category of cutaneous vasculitis (CV). Our work is purposed to explore the predictive value of neutrophil-to-lymphocyte ratio (NLR) for systemic involvement in Henoch– Schonlein purpura patients. This ratio is known as an inflammatory marker, and is used to assess the systemic inflammation associated with various diseases. Our objective is to establish whether it can be applied for the prediction of renal and gastrointestinal (GI) or purely renal involvement in Henoch–Schonlein purpura. Aim: To determine the relationship between neutrophil-to-lymphocyte ratio and systemic involvement in Henoch–Schonlein purpura Methods: This is a retrospective review of the patients who were diagnosed with Henoch–Schonlein purpura in our hospital between 2012 and 2018. Results: A total of 57 patients met our inclusion criteria. Pre-treatment neutrophil-to-lymphocyte ratio was significantly associated with renal and/or GI manifestations of the disease (p<0.001). The optimal cut-off value of this ratio for predicting systemic involvement was 2.48, with a 95% specificity and a 94% sensitivity. In addition, pretreatment ratio was also found to be significantly correlated with the severity of relevant systemic manifestations of Henoch–Schonlein purpura (r=0.831; p<0.01). Limitations: The small number of patients recruited for our research, its retrospective design, and the inclusion of patients attending the same hospital. Conclusion: This study suggests that neutrophil-to-lymphocyte ratio is suitable as a potential indicator for predicting the systemic involvement in Henoch–Schonlein purpura.

scholarly journals Risk factors for renal involvement and severe kidney disease in 2731 Chinese children with Henoch–Schönlein purpura

Medicine ◽  
2018 ◽  
Vol 97 (38) ◽  
pp. e12520 ◽  
Author(s):  
Ke Wang ◽  
Xiaomei Sun ◽  
Yang Cao ◽  
Liang Dai ◽  
Feiyang Sun ◽  
...  
Keyword(s):  
Risk Factors ◽  
Kidney Disease ◽  
Renal Involvement ◽  
Chinese Children ◽  
Henoch Schonlein Purpura ◽  
Schonlein Purpura ◽  
Henoch Schönlein Purpura

scholarly journals Changes of inflammatory mediators and oxidative stress indicators in children with Henoch-Schönlein purpura and clinical effects of hemoperfusion in the treatment of severe Henoch-Schönlein purpura with gastrointestinal involvement in children

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Ying Zhu ◽  
Yang Dong ◽  
Lin Wu ◽  
Fang Deng
Keyword(s):  
Oxidative Stress ◽  
Stress Responses ◽  
Renal Involvement ◽  
Conventional Group ◽  
Henoch Schonlein Purpura ◽  
Tnf Α ◽  
Schonlein Purpura ◽  
Oxidative Stress Responses ◽  
And Oxidative Stress ◽  
Henoch Schönlein Purpura

Abstract Background To explore the changes of inflammatory and oxidative stress responses in Henoch-Schönlein purpura (HSP) children, and further analyzed the therapeutic effects and mechanisms of hemoperfusion (HP) on HSP with severe gastrointestinal (GI) involvement. Methods There were 200 children with HSP were divided into three groups according to their clinical manifestations: 60 in HSP without GI and renal involvement group, 60 in HSP with GI involvement group, and 80 in HSPN group. The HSP with GI involvement group was subdivided into conventional treatment (n = 30) and HP (n = 30) groups. Thirty children who visited the department of children healthcare for healthy physical examinations from January to December 2017 were set as healthy control group. The IL-6 and TNF-α levels were detected by chemoluminescence method. The MDA, SOD and T-AOC levels were determined by thiobarbituric acid colorimetric method, hydroxylamine method and chemical colorimetry. Results Compared with healthy group, IL-6, TNF-α and MDA levels in HSP were increased in each group, while SOD and T-AOC were decreased (P = 0.000). IL-6, TNF-α and MDA levels in the HSPN group were the highest, SOD and T-AOC levels were the lowest (P = 0.000). Compared with those before treatment, IL-6, TNF-α and MDA levels in the conventional and HP groups were decreased and SOD and T-AOC levels were increased (P = 0.000). The changes in HP group were more significant than those in conventional group (P < 0.047). Compared with conventional group, glucocorticoid dosage and the occurrence rate of hematuria and/or proteinuria within 3 months were lower in HP group. (P = 0.000, 0.004). Conclusions Inflammatory and oxidative stress may be involved in the acute phase of HSP children. The intensity of inflammatory and oxidative stress responses were related to the degree of renal involvement. HP can reduce glucocorticoid dosage and the rate of renal involvement in children with severe HSP with GI involvement. The mechanism may be related to the fact that HP can effectively remove IL-6, TNF-α, MDA in HSP children.

scholarly journals Letter: Renal involvement in Henoch-Schonlein purpura.

BMJ ◽  
1974 ◽  
Vol 4 (5941) ◽  
pp. 405-405 ◽  
Author(s):  
J Haahr ◽  
K Thomsen ◽  
S Sparrevohn
Keyword(s):  
Renal Involvement ◽  
Henoch Schonlein Purpura ◽  
Schonlein Purpura ◽  
Henoch Schönlein Purpura
Sign in / Sign up

Export Citation Format

Share Document