scholarly journals Multiomics integrative analysis identifies APOE allele-specific blood biomarkers associated to Alzheimer’s disease etiopathogenesis

Aging ◽  
2021 ◽  
Author(s):  
Laura Madrid ◽  
Sonia Moreno-Grau ◽  
Shahzad Ahmad ◽  
Antonio González-Pérez ◽  
Itziar de Rojas ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Integrative Analysis ◽  
Blood Biomarkers ◽  
Apoe Allele ◽  
Allele Specific

P1-356: SAGE analysis of APOE allele-specific gene expression in hippocampus in Alzheimer's disease

2006 ◽  
Vol 2 ◽  
pp. S202-S202
Author(s):  
John R. Gilbert ◽  
Pu-ting Xu ◽  
Yi-Ju Li ◽  
Xue-Jin Qin ◽  
Christine Hulette ◽  
...  
Keyword(s):  
Gene Expression ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Specific Gene ◽  
Specific Gene Expression ◽  
Apoe Allele ◽  
Allele Specific

scholarly journals Brain-Derived Exosomal Proteins as Effective Biomarkers for Alzheimer’s Disease: A Systematic Review and Meta-Analysis

Biomolecules ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 980
Author(s):  
Ka-Young Kim ◽  
Ki-Young Shin ◽  
Keun-A. Chang
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Web Of Science ◽  
Meta Analysis ◽  
Cochrane Library ◽  
Blood Biomarkers ◽  
Cell Lineages ◽  
The Central Nervous System ◽  
New Biomarkers ◽  
T Tau

Alzheimer’s disease (AD), a progressive neurodegenerative disease, affects approximately 50 million people worldwide, which warrants the search for reliable new biomarkers for early diagnosis of AD. Brain-derived exosomal (BDE) proteins, which are extracellular nanovesicles released by all cell lineages of the central nervous system, have been focused as biomarkers for diagnosis, screening, prognosis prediction, and monitoring in AD. This review focused on the possibility of BDE proteins as AD biomarkers. The articles published prior to 26 January 2021 were searched in PubMed, EMBASE, Web of Science, and Cochrane Library to identify all relevant studies that reported exosome biomarkers in blood samples of patients with AD. From 342 articles, 20 studies were selected for analysis. We conducted a meta-analysis of six BDE proteins and found that levels of amyloid-β42 (standardized mean difference (SMD) = 1.534, 95% confidence interval [CI]: 0.595–2.474), total-tau (SMD = 1.224, 95% CI: 0.534–1.915), tau phosphorylated at threonine 181 (SMD = 4.038, 95% CI: 2.312-5.764), and tau phosphorylated at serine 396 (SMD = 2.511, 95% CI: 0.795–4.227) were significantly different in patients with AD compared to those in control. Whereas, those of p-tyrosine-insulin receptor substrate-1 and heat shock protein 70 did not show significant differences. This review suggested that Aβ42, t-tau, p-T181-tau, and p-S396-tau could be effective in diagnosing AD as blood biomarkers, despite the limitation in the meta-analysis based on the availability of data. Therefore, certain BDE proteins could be used as effective biomarkers for AD.

P4-253: MULTI-OMICS PROFILING IDENTIFIES APOE-ALLELE-ASSOCIATED LIPID AND GENE EXPRESSION PATTERNS IN ALZHEIMER'S DISEASE

2006 ◽  
Vol 14 (7S_Part_29) ◽  
pp. P1543-P1543
Author(s):  
Iliya Lefterov ◽  
Nicholas F. Fitz ◽  
Cody M. Wolfe ◽  
Kyong Nyon Nam ◽  
Florent Letronne ◽  
...  
Keyword(s):  
Gene Expression ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Expression Patterns ◽  
Gene Expression Patterns ◽  
Apoe Allele

Brain Glucose Metabolism: Age, Alzheimer’s Disease, and ApoE Allele Effects

2009 ◽  
pp. 363-373
Author(s):  
A. Pupi ◽  
M.T.R. De Cristofaro ◽  
B. Nacmias ◽  
S. Sorbi ◽  
L. Mosconi
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Glucose Metabolism ◽  
Brain Glucose ◽  
Brain Glucose Metabolism ◽  
Apoe Allele

scholarly journals Identification of Blood Biomarkers for Alzheimer's Disease Through Computational Prediction and Experimental Validation

2019 ◽  
Vol 9 ◽  
Author(s):  
Fang Yao ◽  
Kaoyuan Zhang ◽  
Yan Zhang ◽  
Yi Guo ◽  
Aidong Li ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Experimental Validation ◽  
Computational Prediction ◽  
Blood Biomarkers

P3-150: Blood Biomarkers for Alzheimer's Disease Correlate With Pet Amyloid in AIBL Longitudnal Study of Aging

2016 ◽  
Vol 12 ◽  
pp. P876-P876
Author(s):  
Veer Gupta ◽  
Eugene Hone ◽  
Steve Pedrini ◽  
Ralph N. Martins
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Blood Biomarkers ◽  
Pet Amyloid

scholarly journals Alzheimer’s Disease Susceptibility Gene Apolipoprotein E (APOE) and Blood Biomarkers in UK Biobank (N  =  395,769)

2020 ◽  
pp. 1-11
Author(s):  
Amy C. Ferguson ◽  
Rachana Tank ◽  
Laura M. Lyall ◽  
Joey Ward ◽  
Carlos Celis-Morales ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Apolipoprotein E ◽  
Disease Susceptibility ◽  
Susceptibility Gene ◽  
Uk Biobank ◽  
Blood Biomarkers ◽  
Disease Susceptibility Gene
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