scholarly journals Parathyroid hormone signaling in mature osteoblasts/osteocytes protects mice from age-related bone loss

Aging ◽  
2021 ◽  
Author(s):  
Yuhei Uda ◽  
Vaibhav Saini ◽  
Christopher A. Petty ◽  
Majed Alshehri ◽  
Chao Shi ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Bone Loss ◽  
Hormone Signaling ◽  
Age Related

Subnormal secretion of parathyroid hormone prevents age-related bone loss

1994 ◽  
Vol 12 (S1) ◽  
pp. S69-S70 ◽  
Author(s):  
Kaoru Fujiyama ◽  
Takeshi Kiriyama ◽  
Masako Ito ◽  
Hironori Kimura ◽  
Masako Tsuruta ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Bone Loss ◽  
Age Related

Vitamin D supplementation for 12 months in older people prevents bone loss and suppresses parathyroid hormone levels

2016 ◽  
Author(s):  
Terry J Aspray ◽  
Roger M Francis ◽  
Elaine McColl ◽  
Thomas Chadwick ◽  
Elaine Stamp ◽  
...  
Keyword(s):  
Vitamin D ◽  
Parathyroid Hormone ◽  
Bone Loss ◽  
Older People ◽  
Vitamin D Supplementation ◽  
Hormone Levels

scholarly journals Short carboxyl terminal parathyroid hormone peptides modulate human parathyroid hormone signaling in mouse osteoblasts

2021 ◽  
Vol 572 ◽  
pp. 15-19
Author(s):  
Kittrawee Kritmetapak ◽  
Ravinder J. Singh ◽  
Theodore A. Craig ◽  
Jolaine M. Hines ◽  
Rajiv Kumar
Keyword(s):  
Parathyroid Hormone ◽  
Hormone Signaling ◽  
Human Parathyroid Hormone ◽  
Carboxyl Terminal

scholarly journals Advances in the diagnosis and the management of primary hyperparathyroidism

2021 ◽  
Vol 12 ◽  
pp. 204062232110159
Author(s):  
Ana Kashfia Islam
Keyword(s):  
Renal Function ◽  
Parathyroid Hormone ◽  
Bone Loss ◽  
Primary Hyperparathyroidism ◽  
Kidney Stones ◽  
Parathyroid Glands ◽  
Definitive Treatment ◽  
Indications For Surgery ◽  
Musculoskeletal Complaints ◽  
Parathyroid Cancer

The parathyroid glands, one of the last organs to be discovered, are responsible for maintaining calcium homeostasis, and they continue to present the clinician with diagnostic and management challenges that are reviewed herein. Primary hyperparathyroidism (PHPT) comprises the vast majority of pathology of the parathyroid glands. The classic variant, presenting with elevated calcium and parathyroid hormone levels, has been studied extensively, but the current body of literature has added to our understanding of normocalcemic and normohormonal variants of PHPT, as well as syndromic forms of PHPT. All variants can lead to bone loss, kidney stones, declining renal function, and a variety of neurocognitive, gastrointestinal, and musculoskeletal complaints, although the majority of PHPT today is asymptomatic. Surgery remains the definitive treatment for PHPT, and advances in screening, evolving indications for surgery, new imaging modalities, and improvements in intra-operative methods have greatly changed the landscape. Surgery continues to produce excellent results in the hands of an experienced parathyroid surgeon. For those patients who are not candidates for surgery, therapeutic advances in medical management allow for improved control of the hypercalcemic state. Parathyroid cancer is extremely rare; the diagnosis is often made intra-operatively or on final pathology, and recurrence is common. The mainstay of treatment is normalization of serum calcium via surgery and medical adjuncts.

scholarly journals The Dual Role of Vitamin K2 in “Bone-Vascular Crosstalk”: Opposite Effects on Bone Loss and Vascular Calcification

Nutrients ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 1222
Author(s):  
Domitilla Mandatori ◽  
Letizia Pelusi ◽  
Valeria Schiavone ◽  
Caterina Pipino ◽  
Natalia Di Pietro ◽  
...  
Keyword(s):  
Bone Loss ◽  
Vascular Calcification ◽  
Vascular System ◽  
The Elderly ◽  
Food Supplement ◽  
Vitamin K2 ◽  
Bioactive Molecules ◽  
Calcium Deposition ◽  
Age Related

Osteoporosis (OP) and vascular calcification (VC) represent relevant health problems that frequently coexist in the elderly population. Traditionally, they have been considered independent processes, and mainly age-related. However, an increasing number of studies have reported their possible direct correlation, commonly defined as “bone-vascular crosstalk”. Vitamin K2 (VitK2), a family of several natural isoforms also known as menaquinones (MK), has recently received particular attention for its role in maintaining calcium homeostasis. In particular, VitK2 deficiency seems to be responsible of the so-called “calcium paradox” phenomenon, characterized by low calcium deposition in the bone and its accumulation in the vessel wall. Since these events may have important clinical consequences, and the role of VitK2 in bone-vascular crosstalk has only partially been explained, this review focuses on its effects on the bone and vascular system by providing a more recent literature update. Overall, the findings reported here propose the VitK2 family as natural bioactive molecules that could be able to play an important role in the prevention of bone loss and vascular calcification, thus encouraging further in-depth studies to achieve its use as a dietary food supplement.

The archaeology of osteoporosis

2001 ◽  
Vol 4 (2) ◽  
pp. 263-269 ◽  
Author(s):  
Gordon Turner-Walker ◽  
Unni Syversen ◽  
Simon Mays
Keyword(s):  
Bone Loss ◽  
Femoral Neck ◽  
Young Women ◽  
Rapid Decline ◽  
Mineral Density ◽  
Medieval Women ◽  
Age Related ◽  
Pregnancy And Lactation ◽  
Post Menopausal ◽  
The Uk

The application of medical scanning technologies to archaeological skeletons provides novel insights into the history and potential causes of osteoporosis. The present study investigated bone mineral density (BMD) in medieval skeletons from England and Norway. Comparisons between the two adult populations found no statistically significant differences. This compares with a modern fracture incidence for the femoral neck in women from Norway that is almost three times that in the UK. The pattern of age-related bone loss in medieval men was similar to that seen in men today. In contrast, the pattern in medieval women differed from that of modern young women. On average, medieval women experienced a decrease in BMD at the femoral neck of approximately 23 per cent between the ages of 22 and 35. These losses were partially recovered by age 45, after which BMD values show a decline consistent with post-menopausal bone loss in modern western women. A possible explanation of the rapid decline in BMD in young medieval women is bone loss in connection with pregnancy and lactation in circumstances of insufficient nutrition.

scholarly journals CB2 cannabinoid receptor agonist enantiomers HU-433 and HU-308: An inverse relationship between binding affinity and biological potency

2015 ◽  
Vol 112 (28) ◽  
pp. 8774-8779 ◽  
Author(s):  
Reem Smoum ◽  
Saja Baraghithy ◽  
Mukesh Chourasia ◽  
Aviva Breuer ◽  
Naama Mussai ◽  
...  
Keyword(s):  
Bone Loss ◽  
Binding Affinity ◽  
Cannabinoid Receptors ◽  
Cannabinoid Receptor ◽  
Osteoclast Differentiation ◽  
Protective Mechanism ◽  
Binding Studies ◽  
Age Related ◽  
Comparative Binding ◽  
Biological Potency

Activation of the CB2 receptor is apparently an endogenous protective mechanism. Thus, it restrains inflammation and protects the skeleton against age-related bone loss. However, the endogenous cannabinoids, as well as Δ9-tetrahydrocannabinol, the main plant psychoactive constituent, activate both cannabinoid receptors, CB1 and CB2. HU-308 was among the first synthetic, selective CB2 agonists. HU-308 is antiosteoporotic and antiinflammatory. Here we show that the HU-308 enantiomer, designated HU-433, is 3–4 orders of magnitude more potent in osteoblast proliferation and osteoclast differentiation culture systems, as well as in mouse models, for the rescue of ovariectomy-induced bone loss and ear inflammation. HU-433 retains the HU-308 specificity for CB2, as shown by its failure to bind to the CB1 cannabinoid receptor, and has no activity in CB2-deficient cells and animals. Surprisingly, the CB2 binding affinity of HU-433 in terms of [3H]CP55,940 displacement and its effect on [35S]GTPγS accumulation is substantially lower compared with HU-308. A molecular-modeling analysis suggests that HU-433 and -308 have two different binding conformations within CB2, with one of them possibly responsible for the affinity difference, involving [35S]GTPγS and cAMP synthesis. Hence, different ligands may have different orientations relative to the same binding site. This situation questions the usefulness of universal radioligands for comparative binding studies. Moreover, orientation-targeted ligands have promising potential for the pharmacological activation of distinct processes.

scholarly journals Fgf23 and parathyroid hormone signaling interact in kidney and bone

2016 ◽  
Vol 436 ◽  
pp. 224-239 ◽  
Author(s):  
Olena Andrukhova ◽  
Carmen Streicher ◽  
Ute Zeitz ◽  
Reinhold G. Erben
Keyword(s):  
Parathyroid Hormone ◽  
Hormone Signaling

Cross-sectional assessment of age-related bone loss in men: the MINOS study

Bone ◽  
2000 ◽  
Vol 26 (2) ◽  
pp. 123-129 ◽  
Author(s):  
P Szulc ◽  
F Marchand ◽  
F Duboeuf ◽  
P.D Delmas
Keyword(s):  
Bone Loss ◽  
Cross Sectional ◽  
Age Related
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