scholarly journals A nomogram composed of clinicopathologic features and preoperative serum tumor markers to predict lymph node metastasis in early gastric cancer patients

Oncotarget ◽  
2016 ◽  
Vol 7 (37) ◽  
pp. 59630-59639 ◽  
Author(s):  
Lin-Yong Zhao ◽  
Yuan Yin ◽  
Xue Li ◽  
Chen-Jing Zhu ◽  
Yi-Gao Wang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Early Gastric Cancer ◽  
Cancer Patients ◽  
Tumor Markers ◽  
Clinicopathologic Features ◽  
Node Metastasis ◽  
Preoperative Serum ◽  
Gastric Cancer Patients

scholarly journals Development and validation of a nomogram for preoperative prediction of lymph node metastasis in early gastric cancer

2020 ◽  
Vol 18 (1) ◽  
Author(s):  
Xiao-Yi Yin ◽  
Tao Pang ◽  
Yu Liu ◽  
Hang-Tian Cui ◽  
Tian-Hang Luo ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Early Gastric Cancer ◽  
Cancer Patients ◽  
Validation Cohort ◽  
External Validation ◽  
Training Cohort ◽  
Node Metastasis ◽  
Gastric Cancer Patients

Abstract Background The status of lymph nodes in early gastric cancer is critical to make further clinical treatment decision, but the prediction of lymph node metastasis remains difficult before operation. This study aimed to develop a nomogram that contained preoperative factors to predict lymph node metastasis in early gastric cancer patients. Methods This study analyzed the clinicopathologic features of 823 early gastric cancer patients who underwent gastrectomy retrospectively, among which 596 patients were recruited in the training cohort and 227 patients in the independent validation cohort. Significant risk factors in univariate analysis were further identified to be independent variables in multivariable logistic regression analysis, which were then incorporated in and presented with a nomogram. And internal and external validation curves were plotted to evaluate the discrimination of the nomogram. Results Totally, six independent predictors, including the tumor size, macroscopic features, histology differentiation, P53, carbohydrate antigen 19-9, and computed tomography-reported lymph node status, were enrolled in the nomogram. Both the internal validation in the training cohort and the external validation in the validation cohort showed the nomogram had good discriminations, with a C-index of 0.82 (95%CI, 0.78 to 0.86) and 0.77 (95%CI, 0.60 to 0.94) respectively. Conclusions Our study developed a new nomogram which contained the most common and significant preoperative risk factors for lymph node metastasis in patients with early gastric cancer. The nomogram can identify early gastric cancer patients with the high probability of lymph node metastasis and help clinicians make more appropriate decisions in clinical practice.

scholarly journals Tu1319 – Predictive Factors of Lymph Node Metastasis in Early Gastric Cancer Patients with Seiwert Type Ii/Iii

2019 ◽  
Vol 156 (6) ◽  
pp. S-1025
Author(s):  
Min Young Son ◽  
Sung Eun Kim ◽  
Moo In Park ◽  
Seun Ja Park ◽  
Won Moon ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Early Gastric Cancer ◽  
Cancer Patients ◽  
Predictive Factors ◽  
Type Ii ◽  
Node Metastasis ◽  
Gastric Cancer Patients

scholarly journals Risk factors for lymph node metastasis in early gastric cancer patients: Report from Eastern Europe country– Lithuania

BMC Surgery ◽  
2017 ◽  
Vol 17 (1) ◽  
Author(s):  
Rimantas Bausys ◽  
Augustinas Bausys ◽  
Indre Vysniauskaite ◽  
Kazimieras Maneikis ◽  
Dalius Klimas ◽  
...  
Keyword(s):  
Risk Factors ◽  
Gastric Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Early Gastric Cancer ◽  
Eastern Europe ◽  
Cancer Patients ◽  
Node Metastasis ◽  
Eastern Europe Country ◽  
Gastric Cancer Patients

Nomogram for lymph node metastasis prediction with early gastric cancer patients: To decide additional gastrectomy after endoscopic dissection.

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. 4045-4045
Author(s):  
Su Mi Kim ◽  
Byung-Hoon Min ◽  
Ji Yeong An ◽  
Min-Gew Choi ◽  
Keun Won Ryu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Early Gastric Cancer ◽  
Cancer Patients ◽  
External Validation ◽  
Disease Free Survival ◽  
Free Survival ◽  
Node Metastasis ◽  
Gastric Cancer Patients

4045 Background: Accurate prediction of metastatic lymph node is critical to avoid unnecessary gastrectomy and improve quality of life for patients with early gastric cancer. The aim of this study was to develop and validate a nomogram for prediction of lymph node metastasis in early gastric cancer patients. Methods: We reviewed the clinicopathological data of 10595 patients who underwent curative resection for early gastric cancer from 2001 to 2015 at Samsung Medical Center. This model was externally validated by 2100 patients who underwent curative resection for gastric cancer in National Cancer Center. Multivariate analysis using the Cox proportional hazard regression model was performed to develop the nomogram, and discrimination and calibration were evaluated by external validation. Overall survival, disease free survival, and recurrence free survival were compared between gastrectomy groups of 6641 patients and endoscopic dissection group of 999 patients who was performed the treatment in Samsung Medical Center for early gastric cancer by risk on nomogram to demonstrate the efficacy of nomogram. Results: Multivariate analyses revealed that age, tumor size, lymphatic invasion, depth of invasion, and histologic differentiation were significant prognostic factors for lymph node metastasis. The nomogram had good discrimination with a concordance index of 0.845 [95% confidence interval 0.832-0.858], supported by an external validation point of 0.813[95% confidence interval 0.786-0.84]. In low risk on nomogram, endoscopic dissection group had similar overall survival (P = 0.319), disease free survival (P = 0.469) and recurrence free survival (P = 0.091) compared to gastrectomy group. Conclusions: We developed and validated a nomogram predicting lymph node metastasis for early gastric cancer based on a large database. This personalized nomogram is useful to avoid unnecessary gastrectomy after endoscopic dissection resulting in improved quality of life for early gastric cancer patients.

601. Risk factors for lymph node metastasis in early gastric cancer patients in Lithuanian population

2016 ◽  
Vol 42 (9) ◽  
pp. S179-S180
Author(s):  
A. Baušys ◽  
D. Klimas ◽  
K. Maneikis ◽  
K. Pauža ◽  
E. Sangaila ◽  
...  
Keyword(s):  
Risk Factors ◽  
Gastric Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Early Gastric Cancer ◽  
Cancer Patients ◽  
Node Metastasis ◽  
Gastric Cancer Patients
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