scholarly journals Intra-tumor L-methionine level highly correlates with tumor size in both pancreatic cancer and melanoma patient-derived orthotopic xenograft (PDOX) nude-mouse models

Oncotarget ◽  
2018 ◽  
Vol 9 (13) ◽  
pp. 11119-11125 ◽  
Author(s):  
Kei Kawaguchi ◽  
Qinghong Han ◽  
Shukuan Li ◽  
Yuying Tan ◽  
Kentaro Igarashi ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Mouse Models ◽  
Nude Mouse ◽  
Tumor Size ◽  
Melanoma Patient ◽  
Orthotopic Xenograft ◽  
Methionine Level

scholarly journals Tumor targeting Salmonella typhimurium A1-R in combination with gemcitabine (GEM) regresses partially GEM-resistant pancreatic cancer patient-derived orthotopic xenograft (PDOX) nude mouse models

Cell Cycle ◽  
2018 ◽  
Vol 17 (16) ◽  
pp. 2019-2026 ◽  
Author(s):  
Kei Kawaguchi ◽  
Kentaro Miyake ◽  
Ming Zhao ◽  
Tasuku Kiyuna ◽  
Kentaro Igarashi ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Patient ◽  
Salmonella Typhimurium ◽  
Mouse Models ◽  
Nude Mouse ◽  
Tumor Targeting ◽  
Pancreatic Cancer Patient ◽  
Orthotopic Xenograft

scholarly journals Efficacy of Tumor-Targeting Salmonella A1-R on a Melanoma Patient-Derived Orthotopic Xenograft (PDOX) Nude-Mouse Model

PLoS ONE ◽  
2016 ◽  
Vol 11 (8) ◽  
pp. e0160882 ◽  
Author(s):  
Mako Yamamoto ◽  
Ming Zhao ◽  
Yukihiko Hiroshima ◽  
Yong Zhang ◽  
Elizabeth Shurell ◽  
...  
Keyword(s):  
Mouse Model ◽  
Nude Mouse ◽  
Melanoma Patient ◽  
Tumor Targeting ◽  
Nude Mouse Model ◽  
Orthotopic Xenograft

Patterns of sensitivity to a panel of drugs are highly individualised for undifferentiated/unclassified soft tissue sarcoma (USTS) in patient-derived orthotopic xenograft (PDOX) nude-mouse models

2018 ◽  
Vol 27 (2) ◽  
pp. 211-216 ◽  
Author(s):  
Kei Kawaguchi ◽  
Kentaro Igarashi ◽  
Kentaro Miyake ◽  
Tasuku Kiyuna ◽  
Masuyo Miyake ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Sarcoma ◽  
Mouse Models ◽  
Nude Mouse ◽  
Orthotopic Xenograft

scholarly journals Efficacy of tumor-targeting Salmonella typhimurium A1-R in combination with anti-angiogenesis therapy on a pancreatic cancer patient-derived orthotopic xenograft (PDOX) and cell line mouse models

Oncotarget ◽  
2014 ◽  
Vol 5 (23) ◽  
pp. 12346-12357 ◽  
Author(s):  
Yukihiko Hiroshima ◽  
Yong Zhang ◽  
Takashi Murakami ◽  
Ali Maawy ◽  
Shinji Miwa ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Patient ◽  
Salmonella Typhimurium ◽  
Cell Line ◽  
Mouse Models ◽  
Tumor Targeting ◽  
Pancreatic Cancer Patient ◽  
Orthotopic Xenograft

Abstract 722: Evaluation of a chimeric anti CEA-conjugated antibody with AlexaFlour or Dylight fluorescent dyes for imaging pancreatic cancer in orthotopic nude mouse models.

2013 ◽  
Author(s):  
Ali A. Maawy ◽  
Sharmeela Kaushal ◽  
Cynthia S. Snyder ◽  
George A. Luiken ◽  
Mark A. Talamini ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Mouse Models ◽  
Nude Mouse ◽  
Fluorescent Dyes

scholarly journals Construction of orthotopic xenograft mouse models for human pancreatic cancer

2015 ◽  
Vol 10 (3) ◽  
pp. 1033-1038 ◽  
Author(s):  
LEI DAI ◽  
CAIDE LU ◽  
XI YU ◽  
LONG-JUN DAI ◽  
JEFF X. ZHOU
Keyword(s):  
Pancreatic Cancer ◽  
Mouse Models ◽  
Human Pancreatic Cancer ◽  
Orthotopic Xenograft

scholarly journals Comparison of a chimeric anti-carcinoembryonic antigen antibody conjugated with visible or near-infrared fluorescent dyes for imaging pancreatic cancer in orthotopic nude mouse models

2013 ◽  
Vol 18 (12) ◽  
pp. 126016 ◽  
Author(s):  
Ali A. Maawy ◽  
Yukihiko Hiroshima ◽  
Sharmeela Kaushal ◽  
George A. Luiken ◽  
Robert M. Hoffman ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Carcinoembryonic Antigen ◽  
Mouse Models ◽  
Nude Mouse ◽  
Near Infrared ◽  
Fluorescent Dyes ◽  
Antigen Antibody

scholarly journals Metabolomic Detection Between Pancreatic Cancer and Liver Metastasis Nude Mouse Models Constructed by Using the PANC1-KAI1/CD82 Cell Line

2021 ◽  
Vol 20 ◽  
pp. 153303382110452
Author(s):  
Shuo Wang ◽  
Jiang Chen ◽  
Hongyu Li ◽  
Xingshun Qi ◽  
Xu Liu ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Liver Metastasis ◽  
Cell Line ◽  
Mouse Models ◽  
Nude Mouse ◽  
Ultra Performance Liquid Chromatography ◽  
Guanosine Monophosphate ◽  
Serum Samples ◽  
Kegg Pathways ◽  
Panc1 Cell

Background: Pancreatic cancer (PC) has a poor prognosis and is prone to liver metastasis. The KAI1/CD82 gene inhibits PC metastasis. This study aimed to explore differential metabolites and enrich the pathways in serum samples between PC and liver metastasis nude mouse models stably expressing KAI1/CD82. Methods: KAI1/CD82-PLV-EF1α-MCS-IRES-Puro vector and PANC1 cell line stably expressing KAI1/CD82 were constructed for the first time. This cell line was used to construct 3 PC nude mouse models and 3 liver metastasis nude mouse models. The different metabolites and Kyoto encyclopedia of genes and genomes (KEGG) and human metabolome database (HMDB) enrichment pathways were analyzed using the serum samples of the 2 groups of nude mouse models on the basis of untargeted ultra-performance liquid chromatography-tandem mass spectrometry platform. Results: KAI1/CD82-PLV-EF1α-MCS-IRES-Puro vector and PANC1 cell line stably expressing KAI1/CD82 were constructed successfully, and all nude mouse models survived and developed cancers. Among the 1233 metabolites detected, 18 metabolites (9 upregulated and 9 downregulated) showed differences. In agreement with the literature data, the most significant differences between both groups were found in the levels of bile acids (taurocholic acid, chenodeoxycholic acid), glycine, prostaglandin E2, vitamin D, guanosine monophosphate, and inosine. Bile recreation, primary bile acid biosynthesis, and purine metabolism KEGG pathways and a series of HMDB pathways ( P < .05) contained differential metabolites that may be associated with liver metastasis from PC. However, the importance of these metabolites on PC liver metastases remains to be elucidated. Conclusions: Our findings suggested that the metabolomic approach may be a useful method to detect potential biomarkers in PC.

MEK inhibitor trametinib in combination with gemcitabine regresses a patient-derived orthotopic xenograft (PDOX) pancreatic cancer nude mouse model

2018 ◽  
Vol 52 ◽  
pp. 124-128 ◽  
Author(s):  
Kei Kawaguchi ◽  
Kentaro Igarashi ◽  
Kentaro Miyake ◽  
Thinzar M. Lwin ◽  
Masuyo Miyake ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Mouse Model ◽  
Nude Mouse ◽  
Mek Inhibitor ◽  
Nude Mouse Model ◽  
Orthotopic Xenograft
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