scholarly journals Mutually exclusive lymphangiogenesis or perineural infiltration in human skin squamous-cell carcinoma

Oncotarget ◽  
2021 ◽  
Vol 12 (7) ◽  
pp. 638-648
Author(s):  
Julien Schaller ◽  
Hélène Maby-El Hajjami ◽  
Sylvie Rusakiewicz ◽  
Kalliopi Ioannidou ◽  
Nathalie Piazzon ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Human Skin ◽  
Squamous Cell ◽  
Skin Squamous Cell Carcinoma

The inhibition of resveratrol to human skin squamous cell carcinoma A431 xenografts in nude mice

Fitoterapia ◽  
2013 ◽  
Vol 86 ◽  
pp. 84-91 ◽  
Author(s):  
Yuqin Hao ◽  
Weixing Huang ◽  
Mingmei Liao ◽  
Yude Zhu ◽  
Hong Liu ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Human Skin ◽  
Squamous Cell ◽  
Nude Mice ◽  
Skin Squamous Cell Carcinoma

scholarly journals Expression and function of NET-1 in human skin squamous cell carcinoma

2013 ◽  
Vol 306 (4) ◽  
pp. 385-397 ◽  
Author(s):  
Jie zhang ◽  
Jianli Wang ◽  
Li Chen ◽  
Guilan Wang ◽  
Jing Qin ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Human Skin ◽  
Squamous Cell ◽  
Skin Squamous Cell Carcinoma ◽  
And Function

scholarly journals Connexin26 Modulates the Radiosensitivity of Cutaneous Squamous Cell Carcinoma by Regulating the Activation of the MAPK/NF-κB Signaling Pathway

2021 ◽  
Vol 9 ◽  
Author(s):  
Minqiong Sun ◽  
Yuan Li ◽  
Jing Qian ◽  
Siwei Ding ◽  
Mingyu Sun ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Human Skin ◽  
Squamous Cell ◽  
Human Keratinocytes ◽  
Cutaneous Squamous Cell Carcinoma ◽  
A431 Cells ◽  
Skin Squamous Cell Carcinoma ◽  
Junction Protein ◽  
Clinical Radiotherapy

Previous studies have confirmed that the gap junction protein Connexin26 (Cx26) is specifically expressed in human skin tissue. Cx26 can transmit radiation-induced damage signals. However, no study has yet reported whether Cx26 expression affects the radiosensitivity of human skin squamous cancer cells or the mechanism by which this occurs. In this study, we found that human skin squamous cell carcinoma cells (A431 cells) expressed significantly more Cx26 and were more sensitive to radiation compared to normal human keratinocytes (HaCaT cells). Knockdown of Cx26 in A431 cells (A431Cx26–/–) decreased radiosensitivity relative to control cells and altered the expression of key proteins in the MAPK and NF-κB signaling pathways. These results demonstrate that Cx26 expression might play an important role in mediating radiation damage in A431 cells and could serve as a potential target for clinical radiotherapy for cutaneous squamous cell carcinoma.

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