scholarly journals Identification of cardiac-related circulating microRNA profile in human chronic heart failure

Oncotarget ◽  
2015 ◽  
Vol 7 (1) ◽  
pp. 33-45 ◽  
Author(s):  
Huaping Li ◽  
Jiahui Fan ◽  
Zhongwei Yin ◽  
Feng Wang ◽  
Chen Chen ◽  
...  
Keyword(s):  
Heart Failure ◽  
Chronic Heart Failure ◽  
Circulating Microrna ◽  
Microrna Profile

Expression of circulating microRNA in chronic heart failure in patients with cardiovascular pathologies

2016 ◽  
Vol 5 (1) ◽  
pp. 26 ◽  
Author(s):  
A. G. Kochetov ◽  
O. V. Lyang ◽  
R. R. Gimadiev ◽  
A. A. Abramov ◽  
I. V. Zhirov ◽  
...  
Keyword(s):  
Heart Failure ◽  
Chronic Heart Failure ◽  
Circulating Microrna ◽  
Cardiovascular Pathologies

scholarly journals Circulating microRNA-132 levels improve risk prediction for heart failure hospitalization in patients with chronic heart failure

2017 ◽  
Vol 20 (1) ◽  
pp. 78-85 ◽  
Author(s):  
Serge Masson ◽  
Sandor Batkai ◽  
Julia Beermann ◽  
Christian Bär ◽  
Angelika Pfanne ◽  
...  
Keyword(s):  
Heart Failure ◽  
Chronic Heart Failure ◽  
Risk Prediction ◽  
Circulating Microrna ◽  
Heart Failure Hospitalization

Abstract 251: Circulating Mir-21, -378, and -940 Increase in Response to an Acute Exhaustive Exercise in Patients With Chronic Heart Failure

2015 ◽  
Vol 117 (suppl_1) ◽  
Author(s):  
Tianzhao Xu ◽  
Qiulian Zhou ◽  
Lin Che ◽  
Guanghe Li ◽  
Junjie Xiao
Keyword(s):  
Heart Failure ◽  
Creatine Kinase ◽  
Chronic Heart Failure ◽  
Muscle Damage ◽  
Acute Exercise ◽  
Nyha Class ◽  
Exhaustive Exercise ◽  
Exercise Session ◽  
Circulating Microrna ◽  
Creatine Kinase Mb

Background: Exercise training is recommended as a useful intervention in cardiac rehabilitation for patients with chronic heart failure. There has been emerging evidence indicating that circulating microRNA (miRNA, miR) could mediate the beneficial effects of exercise in both healthy persons and patients with cardiovascular diseases. The current study was aimed to investigate the regulation of circulating miRNAs in response to an acute exhaustive exercise in patients with chronic heart failure (CHF). Methods: Twenty-eight CHF patients (mean age=59.07±1.79 years, 14 in NYHA Class II and 14 in NYHA Class III) performed a symptom-limited incremental cardiopulmonary exercise test on a bicycle ergometer according to a standardized exercise protocol of revised Ramp10 programs (acute exercise). Serum samples were collected before and immediately after exercise session. The cardiac or muscle specific/enriched miRNAs including miR-1, miR-133a, miR-133b, miR-499, miR-208a, miR-208b, miR-378, miR-486, and miR-940 were determined. In addition, other miRNAs involved in angiogenesis (miR-20a, miR-328, miR-126, miR-221), inflammation (miR-21, miR-146a, miR-155), and ischemia adaptation (miR-210, miR-21, miR-146a) were also investigated. Moreover, inflammatory and muscle damage markers including creatine kinase (CK), creatine kinase MB isoenzyme (CK-MB), troponin T (Tn-T), N-terminal pro-brain natriuretic peptide (NT-ProBNP) and high sensitive C reactive protein (hs-CRP) were determined by enzyme linked immunosorbent assays (ELISA). Results: Serum miR-21, -378, and -940 were found to be significantly increased in response to acute exercise in CHF patients. In addition, no robust correlation was identified between changes of these miRNAs and muscle damage or inflammation, indicating a distinct adaptation by miRNAs. However, a linear correlation between the change of miR-21 and VO2max was observed (R=0.42, P=0.03). Conclusion: Our data suggest that circulating miR-21, miR-378, and miR-940 might be potential biomarkers for the improvement of exercise capacity in patients with chronic heart failure.

Statin Therapy Offers No Benefit in Chronic Heart Failure

2008 ◽  
Vol 41 (19) ◽  
pp. 36
Author(s):  
BRUCE JANCIN
Keyword(s):  
Heart Failure ◽  
Chronic Heart Failure ◽  
Statin Therapy

85 The value of repeated measurement of N-terminal pro-B-type natriuretic peptide for prognostic stratification in chronic heart failure

2007 ◽  
Vol 6 (1) ◽  
pp. 18-19
Author(s):  
M KUBANEK ◽  
K GOODE ◽  
A RABSHAIKH ◽  
I HANNING ◽  
A CLARK ◽  
...  
Keyword(s):  
Heart Failure ◽  
Chronic Heart Failure ◽  
Natriuretic Peptide ◽  
Repeated Measurement ◽  
Prognostic Stratification

79 Serum tumor necrosis-alpha levels upon discharge predict 180-day mortality in patients hospitalized for acute decompensated chronic heart failure

2007 ◽  
Vol 6 (1) ◽  
pp. 16-17
Author(s):  
D MYTAS ◽  
M ZAIRIS ◽  
K KONTOS ◽  
M PRODROMITI ◽  
P BATIKAZAIRI ◽  
...  
Keyword(s):  
Heart Failure ◽  
Chronic Heart Failure ◽  
Tumor Necrosis ◽  
Serum Tumor Necrosis
Sign in / Sign up

Export Citation Format

Share Document