scholarly journals ERα propelled aberrant global DNA hypermethylation by activating the DNMT1 gene to enhance anticancer drug resistance in human breast cancer cells

Oncotarget ◽  
2016 ◽  
Vol 7 (15) ◽  
pp. 20966-20980 ◽  
Author(s):  
Xinxin Si ◽  
Yue Liu ◽  
Jinghuan Lv ◽  
Haijian Ding ◽  
Xin A. Zhang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Drug Resistance ◽  
Cancer Cells ◽  
Anticancer Drug ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Dna Hypermethylation ◽  
Anticancer Drug Resistance

scholarly journals An integrative genomic analysis revealed the relevance of microRNA and gene expression for drug-resistance in human breast cancer cells

2011 ◽  
Vol 10 (1) ◽  
pp. 135 ◽  
Author(s):  
Yusuke Yamamoto ◽  
Yusuke Yoshioka ◽  
Kaho Minoura ◽  
Ryou-u Takahashi ◽  
Fumitaka Takeshita ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Gene Expression ◽  
Drug Resistance ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Genomic Analysis ◽  
Human Breast Cancer Cells ◽  
Human Breast

scholarly journals Choline kinase overexpression increases invasiveness and drug resistance of human breast cancer cells

2010 ◽  
Vol 23 (6) ◽  
pp. 633-642 ◽  
Author(s):  
Tariq Shah ◽  
Flonne Wildes ◽  
Marie-France Penet ◽  
Paul T. Winnard ◽  
Kristine Glunde ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Drug Resistance ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Choline Kinase ◽  
Human Breast Cancer Cells ◽  
Human Breast

Delivery of siRNA by MRI-visible nanovehicles to overcome drug resistance in MCF-7/ADR human breast cancer cells

Biomaterials ◽  
2014 ◽  
Vol 35 (35) ◽  
pp. 9495-9507 ◽  
Author(s):  
Gan Lin ◽  
Wencheng Zhu ◽  
Li Yang ◽  
Jun Wu ◽  
Bingbing Lin ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Drug Resistance ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Mcf 7

scholarly journals Proapoptotic and Antiproliferative Effects ofThymus caramanicuson Human Breast Cancer Cell Line (MCF-7) and Its Interaction with Anticancer Drug Vincristine

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Saeed Esmaeili-Mahani ◽  
Farzaneh Falahi ◽  
Mohammad Mehdi Yaghoobi
Keyword(s):  
Breast Cancer ◽  
Cyclin D1 ◽  
Cancer Cells ◽  
Anticancer Drug ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Caspase 3 ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Mcf 7

Thymus caramanicus Jalasis one of the species of thymus that grows in the wild in different regions of Iran. Traditionally, leaves of this plant are used in the treatment of diabetes, arthritis, and cancerous situation. Therefore, the present study was designed to investigate the selective cytotoxic and antiproliferative properties ofThymus caramanicusextract (TCE). MCF-7 human breast cancer cells were used in this study. Cytotoxicity of the extract was determined using MTT and neutral red assays. Biochemical markers of apoptosis (caspase 3, Bax, and Bcl-2) and cell proliferation (cyclin D1) were evaluated by immunoblotting. Vincristine was used as anticancer control drug in extract combination therapy. The data showed that incubation of cells with TCE (200 and 250 μg/mL) significantly increased cell damage, activated caspase 3 and Bax/Bcl2 ratio. In addition, cyclin D1 was significantly decreased in TCE-treated cells. Furthermore, concomitant treatment of cells with extract and anticancer drug produced a significant cytotoxic effect as compared to extract or drugs alone. In conclusion, thymus extract has a potential proapoptotic/antiproliferative property against human breast cancer cells and its combination with chemotherapeutic agent vincristine may induce cell death effectively and be a potent modality to treat this type of cancer.

Stress hormones mediate drug resistance to paclitaxel in human breast cancer cells through a CDK-1-dependent pathway

2009 ◽  
Vol 34 (10) ◽  
pp. 1533-1541 ◽  
Author(s):  
Melanie S. Flint ◽  
Grace Kim ◽  
Brian L. Hood ◽  
Nicholas W. Bateman ◽  
Nicolas A. Stewart ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Drug Resistance ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Stress Hormones ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Dependent Pathway

scholarly journals HER2 confers drug resistance of human breast cancer cells through activation of NRF2 by direct interaction

2014 ◽  
Vol 4 (1) ◽  
Author(s):  
Hyo Jin Kang ◽  
Yong Weon Yi ◽  
Young Bin Hong ◽  
Hee Jeong Kim ◽  
Young-Joo Jang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Drug Resistance ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Direct Interaction ◽  
Human Breast Cancer Cells ◽  
Human Breast
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