scholarly journals THE ROLE OF SALIVARY GLAND BIOPSY IN DIAGNOSIS OF SYSTEMIC DISEASES AND THEIR LYMPHOPROLIFERATIVE COMPLICATIONS

2017 ◽  
Vol 21 (4) ◽  
pp. 218-224
Author(s):  
Ekaterina Borisovna Rodionova
Keyword(s):  
Salivary Gland ◽  
Salivary Glands ◽  
Malignant Tumors ◽  
Diagnostic Value ◽  
Pathological Process ◽  
Al Amyloidosis ◽  
Biliary Cirrhosis ◽  
Systemic Diseases ◽  
Viral Hepatitis C ◽  
Salivary Gland Biopsy

The clinical picture of many systemic diseases (SD) could make its debut in the maxillofacial area with salivary gland lesions. Sjogren’s sicca syndrome, IgG4-related diseases, sarcoidosis, viral hepatitis - C, primary biliary cirrhosis, autoimmune hepatitis, as well as complications of the plurality of abnormalities in the form of lymphoproliferative diseases including AL-amyloidosis and B-cell lymphomas of different malignant tumors. The main diagnostic criteria in this case are the data of histological and immunohistochemistry studies of affected tissues. The aim of this publication is to analyze literature data on the pathological changes developing in salivary glands at different SD. The question about the diagnostic value of limphoplazmatsitarny infiltrate detected in the salivary gland biopsy materials SD and its influence on the prognosis and course of pathological process remains open. Conclusions: salivary glands biopsy has played a significant role in the early diagnosis and follow-up of patients with a variety of SD occurring with salivary gland lesions and such research studies have been required to continue.

Diagnostic Value of Salivary Gland Ultrasonographic Scoring System in Primary Sjögren’s Syndrome: A Comparison with Scintigraphy and Biopsy

2009 ◽  
Vol 36 (7) ◽  
pp. 1495-1500 ◽  
Author(s):  
VERA D. MILIC ◽  
RADMILA R. PETROVIC ◽  
IVAN V. BORICIC ◽  
JELENA MARINKOVIC-ERIC ◽  
GORAN L. RADUNOVIC ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Salivary Glands ◽  
Scoring System ◽  
Sjogren’S Syndrome ◽  
Diagnostic Value ◽  
Sjogren's Syndrome ◽  
Primary Sjögren’S Syndrome ◽  
Primary Sjogren’S Syndrome ◽  
Primary Sjögren's Syndrome ◽  
Salivary Gland Biopsy

Objective.To compare an ultrasonographic (US) scoring system of salivary glands with scintigraphy and salivary gland biopsy, in order to evaluate its diagnostic value in primary Sjögren’s syndrome (SS).Methods.In 135 patients with suspected SS, the grades of 5 US measures of both parotid and submandibular salivary glands were scored (0–48 scale). Diagnosis of primary SS was established following the American-European Consensus Group criteria of 2002. The patients’ total scintigraphic score (0–12 scale) was determined and the histopathological changes of minor salivary glands graded. Area under the receiver-operating characteristic (ROC) curve was employed to evaluate the diagnostic value of the US scoring system.Results.Primary SS was diagnosed in 107 (79.2%) patients and the remaining 28 subjects (20.8%) constituted the control group. US changes of salivary glands were established in 98/107 patients with SS and in 14/28 controls. Mean US score was 26 in SS patients and 6 in controls. Through ROC curves, US arose as the best performer (0.95 ± 0.01), followed by scintigraphy (0.86 ± 0.31). Setting the cutoff score for US at 19 resulted in the best ratio of specificity (90.8%) to sensitivity (87.1%), while setting the cutoff scintigraphic score at 6 resulted in specificity of 86.1% and sensitivity of 67.1%. Among 70 patients with US score ≥ 19, a scintigraphic score > 6 was recorded in 54/70 (77.1%) and positive biopsy findings in 62/70 (88.5%) patients.Conclusion.We show high diagnostic accuracy of a novel US scoring system of salivary glands (0–48) in patients with primary SS comparable to invasive methods, i.e., scintigraphy and salivary gland biopsy.

Rare case of epidemic mumps

1997 ◽  
Vol 78 (2) ◽  
pp. 133-133
Author(s):  
H. S. Khaertynov
Keyword(s):  
Salivary Gland ◽  
Salivary Glands ◽  
Rare Case ◽  
Pathological Process ◽  
Epidemic Parotitis ◽  
Mumps Infection

Diagnosis of epidemic parotitis (EP) in typical cases of the disease is not difficult, which is explained by the salivary gland involvement characteristic of this infection. It is known that in the pathological process of ES, in addition to salivary glands, pancreas, testicles, etc. can be involved. At the same time, different authors assess the possibility of their isolated involvement ambiguously: either pancreatitis or orchitis are the only manifestations of mumps infection, or involvement of salivary glands in the pathological process is a mandatory component of ES and, therefore, involvement of other glands cannot be isolated.

scholarly journals Epidemiologic Characteristics of Salivary Gland Tumors in an Iranian Population

2021 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Nafise Shamloo ◽  
Alireza Ghanadan ◽  
Fahimeh Sadat Hashemian ◽  
Maedeh Ghorbanpour
Keyword(s):  
Salivary Gland ◽  
Adenoid Cystic Carcinoma ◽  
Salivary Glands ◽  
Pleomorphic Adenoma ◽  
Malignant Tumors ◽  
The Body ◽  
Salivary Gland Tumors ◽  
Benign Tumors ◽  
Cross Sectional ◽  
Adenoid Cystic

Background: Salivary gland tumors include a wide variety of benign and malignant tumors in the oral and maxillofacial region. Although these tumors are not common, they are not rare. The prevalence of these tumors varies with regard to age, gender, and their location in the body. Objectives: This study aimed to evaluate the frequency of benign and malignant salivary gland tumors in patients referred to three referral hospitals in Tehran, Iran. Methods: This retrospective cross-sectional study examined the demographic and pathologic records of the patients with salivary gland tumors submitted to the Department of Pathology of Amir Alam, Loghman Hakim, and Shohada Hospitals from 2005 to 2016. In this study, the histological variants of salivary gland tumors and clinical parameters such as age, gender, and the location of the tumor were examined. The clinical data were analyzed using SPSS software version 21. Results: Of 137632 patient records, 1180 cases were salivary gland tumors. Pleomorphic adenoma in 794 cases (67.3%) and adenoid cystic carcinoma in 109 cases (9.2%) were the most common tumors, respectively. Salivary gland tumors were more common in males, and the participants’ mean age was 42.86 ± 16.5 years. The most common site was parotid and minor salivary glands, with 937 (79.4%) and 137 (12%) cases, respectively. Conclusions: In this study, the most common benign tumor was pleomorphic adenoma in the parotid gland, and the most common malignant tumor was adenoid cystic carcinoma in the major salivary glands. Furthermore, benign tumors were more frequent than malignant tumors.

scholarly journals Salivary Gland Pathologies

2021 ◽  
pp. 939-973
Author(s):  
Nisheet Anant Agni
Keyword(s):  
Salivary Gland ◽  
Salivary Glands ◽  
Malignant Tumors ◽  
Inflammatory Conditions ◽  
Major Salivary Glands

AbstractSaliva is responsible for various functions from lubrication to digestion. The saliva is secreted by numerous minor and major salivary glands. These salivary glands are sometimes affected by various local and systemic inflammatory conditions, obstructive pathologies with benign and malignant tumors. This chapter deals with various pathologies of salivary glands and their management.

Human Kallikrein 14 (Klk14) Expression in Salivary Gland Tumors

2010 ◽  
Vol 25 (1) ◽  
pp. 32-37 ◽  
Author(s):  
Nelly N. Hashem ◽  
Thomas W. Mara ◽  
Mohamed Mohamed ◽  
Irene Zhang ◽  
Kevin Fung ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Salivary Glands ◽  
Malignant Tumors ◽  
Expression Profiles ◽  
Staining Technique ◽  
Tumor Stage ◽  
Salivary Gland Tumors ◽  
Immunoperoxidase Staining ◽  
Clinical Parameters ◽  
Ductal Cells

Objective To analyze the expression of human kallikrein 14 (KLK14) in salivary gland tumors. Methods A standard immunoperoxidase staining technique was used to assess the expression profile of KLK14 in normal salivary glands and tumors including pleomorphic adenoma (PA; n=17), adenoid cystic carcinoma (ACC; n=13) and mucoepidermoid carcinoma (MEC; n=9). Tumor stage, grade, patient age and gender, and site of occurrence were recorded. These clinical parameters were correlated with KLK14 levels in malignant tumors. The expression profiles for KLK3, 5, 6, 8 and 13 were also retrieved. Results Normal salivary glands, PA, ACC and MEC showed strong expression of KLK14 in ductal and non-ductal cells. Both PA and ACC showed higher KLK14 levels than normal glands and MEC tissues. There were no statistically significant associations between levels of KLK14 and clinical parameters. Conclusions The differences in the levels of KLK14 suggest that KLKs may aid in the differential diagnosis of salivary gland tumors. The coexpression of KLKs suggests their possible involvement in an enzymatic pathway activated in salivary gland. KLK14 may be a promising new biomarker in salivary gland tumors.

scholarly journals RADIATION METHODS FOR DIAGNOSIS OF SALIVARY GLAND DISEASES. REVIEW

2017 ◽  
Vol 13 (1-2) ◽  
pp. 113-121
Author(s):  
T.V. Topchiy ◽  
D.V. Topchiy
Keyword(s):  
Salivary Gland ◽  
Salivary Glands ◽  
Malignant Tumors ◽  
Inflammatory Diseases ◽  
Diagnostic Methods ◽  
Salivary Gland Diseases ◽  
Methods Development ◽  
Ultrasound Diagnostics ◽  
History Of ◽  
Diagnostic Capabilities

In modern conditions, the application of radiodiagnosis of salivary gland diseases requires a profound knowledge of the physical and technical bases and their scientific and methodological peculiarities. There are presented information on the history of discovery and diagnostic capabilities of some methods of radiation diagnosis. Analogue sialography at a certain stage of the application gave clinicians valuable information. In the diagnosis of inflammatory diseases, there is a predominance of traditional sialogram. The functional digital subtraction sialography allow us to eliminate traditional sialogram disadvantages. This method is considered the gold standard for the diagnosis of salivary ducts. Computer tomographic sialography is the most valuable for the diagnosis of salivary gland tumors, allows differential diagnosis between benign and malignant tumors. An important advantage of salivary gland scintigraphy in comparison with other imaging methods is that both the secretory function and the excretory fraction of all four major salivary glands. Glands can be simultaneously quantified using a single injection. The method of ultrasound diagnostics allows to detect both malformations and inflammatory, degenerative-dystrophic processes, has some clear advantages in comparison with sialography, scintigraphy, computed tomography, since neither x-ray nor magnetic field is used, the duration of the procedure is shortened, the tomographic plane can be easily manipulated, metal bodies do not interfere. Conclusion. Complex application of radiation diagnostic methods, development of algorithms for the diagnosis of salivary glands can become a source of accurate and practically meaningful information.

SAT0553 Diagnostic Value of Quantitative Sialoscintigraphy Compared To Labial Salivary Gland Biopsy in Patients with Suspected Sjögren' Syndrome

2016 ◽  
Vol 75 (Suppl 2) ◽  
pp. 869.2-869
Author(s):  
M. Garcia Gonzalez ◽  
H. Sanchez Perez ◽  
I. Ferraz Amaro ◽  
V. Hernandez Hernandez ◽  
B. Rodriguez Lozano ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Diagnostic Value ◽  
Sjögren Syndrome ◽  
Sjogren Syndrome ◽  
Labial Salivary Gland ◽  
Labial Salivary Gland Biopsy ◽  
Salivary Gland Biopsy

scholarly journals Comprehensive study of salivary gland neoplasms: single department study in a tertiary care centre

2019 ◽  
Vol 5 (3) ◽  
pp. 581
Author(s):  
S. Muthuchitra ◽  
V. Saravanaselvan ◽  
R. Malarvizhi
Keyword(s):  
Salivary Gland ◽  
Facial Nerve ◽  
Salivary Glands ◽  
Malignant Tumors ◽  
Tertiary Care ◽  
Female Gender ◽  
Salivary Gland Neoplasms ◽  
Malignant Neoplasms ◽  
Tertiary Care Centre ◽  
General Surgeons

<p class="abstract"><strong>Background:</strong> Pathologies of salivary glands are common in the general population. Of them few are neoplasms-benign or malignant. The presentation of salivary gland pathologies are both to general surgeons and otorhinolaryngologists of the same hospital. The presentation to concerned treating surgeon is based on the symptoms during presentation. This study aims at the various types of salivary gland pathologies requiring surgical intervention and the rate of recurrence following surgery in a single department.</p><p class="abstract"><strong>Methods:</strong> Retrospective study was conducted. Study period was from May 2017 to February 2019. All salivary gland neoplasms were studied for presentation and recurrence following surgery.  </p><p class="abstract"><strong>Results:</strong> Intraoperative difficulties and post-operative complications more common in malignant tumors. Female gender is more commonly affected by benign neoplasms. There is no gender predilection in malignant neoplasms. Facial nerve is most common nerve to get affected in pre-operative and during surgery as well.</p><p class="abstract"><strong>Conclusions:</strong> Neoplasms of salivary glands are common in females though it has equal incidence in malignancy. Facial nerve is most commonly affected as complication in malignant neoplasms.</p>

scholarly journals Secondary Sjögren's in patients with systemic scleroderma

2019 ◽  
Vol 3 (23) ◽  
pp. 37-39
Author(s):  
E. I. Selifanova ◽  
M. S. Esayan
Keyword(s):  
Salivary Gland ◽  
Salivary Glands ◽  
Minor Salivary Gland ◽  
Systemic Scleroderma ◽  
Minor Salivary Glands ◽  
Minor Salivary Gland Biopsy ◽  
European Consensus ◽  
Salivary Gland Biopsy ◽  
Morphological Differences ◽  
Lymphoid Infiltration

The aim of the study was to investigate the morphological differences of the minor salivary glands in patients with secondary Sjögren's syndrome associated with systemic scleroderma (Scl-SS). Total of 40 patients were grouped according to the American–European Consensus Group criteria. Information about the duration of the disease was taken from the patients records. Sections of the minor salivary gland biopsy were reevaluated, and the lymphocyte focus score (FS), plasma cell focus, and fibrosis rates were all evaluated. The groups were formed according to the duration of the disease: less than and over 5 years.Results. Scl-SS leads to changes in both in the large salivary glands and in the MSG, manifested in the form of mucoid swelling, fibrinoid changes, hyalinosis and sclerosis. In patients with Scl-SS the progression of the process leads to the destruction of the duct wall and to the focal and diffuse lymphoid infiltration.

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