Postnatal Corticosteroids in the Treatment of Chronic Lung Disease in the Preterm Infant: Past, Present, and Future

2007 ◽  
Vol 26 (5) ◽  
pp. 293-299 ◽  
Author(s):  
Julie Nye

Over the past 20 years, corticosteroid use in the preterm infant has fallen in and out of favor. Steroids were introduced in the 1980s as a mode of preventing and treating chronic lung disease (CLD) in the preterm infant population. This use has been targeted toward low birth weight infants who are unable to wean off the ventilator. Dose, duration, and timing of treatment with dexamethasone, the steroid typically used in NICUs, has varied. This article examines why the medication has fallen out of favor and whether postnatal corticosteroids still have a place in preventing and treating CLD.

PEDIATRICS ◽  
2001 ◽  
Vol 108 (1) ◽  
pp. 212-214
Author(s):  
J. P. Shenai; ◽  
P. Rimensberger; ◽  
U. Thome ◽  
F. Pohlandt; ◽  
P. Rimensberger

2014 ◽  
Vol 168 (11) ◽  
pp. 1039 ◽  
Author(s):  
Veeral N. Tolia ◽  
Karna Murthy ◽  
Pam S. McKinley ◽  
Monica M. Bennett ◽  
Reese H. Clark

PEDIATRICS ◽  
1987 ◽  
Vol 79 (1) ◽  
pp. 26-30 ◽  
Author(s):  
Mary Ellen Avery ◽  
William H. Tooley ◽  
Jacob B. Keller ◽  
Suzanne S. Hurd ◽  
M. Heather Bryan ◽  
...  

Chronic lung disease in prematurely born infants, defined as the need for increased inspired oxygen at 28 days of age, was thought to be more common in some institutions than in others. To test this hypothesis, we surveyed the experience in the intensive care nurseries at Columbia and Vanderbilt Universities, the Universities of Texas at Dallas, Washington at Seattle, and California at San Francisco, the Brigham and Women's Hospital in Boston, Texas Children's Hospital in Houston, and Mt Sinai Hospital in Toronto. The survey included 1,625 infants with birth weights of 700 to 1,500 g. We confirmed the relationship of risk to low birth weight, white race, and male sex. Significant differences in the incidence of chronic lung disease were found between institutions even when birth weight, race, and sex were taken into consideration through a multivariate logistic regression analysis. Columbia had one of the best outcomes for low birth weight infants and the lowest incidence of chronic lung disease.


2011 ◽  
Author(s):  
Atsushi Kawaguchi ◽  
Rintaro Mori ◽  
Hirotaka Minami ◽  
Masonori Tamura ◽  
Ying Yang

1997 ◽  
Vol 130 (2) ◽  
pp. 305-309 ◽  
Author(s):  
Cindy McEvoy ◽  
Maria Elena Mendoza ◽  
Susan Bowling ◽  
Valerie Hewlett ◽  
Smeeta Sardesai ◽  
...  

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