scholarly journals Modular Cognitive Therapy for Obsessive-Compulsive Disorder: A Wait-List Controlled Trial

2009 ◽  
Vol 23 (4) ◽  
pp. 294-305 ◽  
Author(s):  
Sabine Wilhelm ◽  
Gail Steketee ◽  
Jeanne M. Fama ◽  
Ulrike Buhlmann ◽  
Bethany A. Teachman ◽  
...  
Keyword(s):  
Cognitive Therapy ◽  
Obsessive Compulsive Disorder ◽  
Controlled Trial ◽  
Post Treatment ◽  
Wait List ◽  
Obsessive Compulsive ◽  
Wait List Group ◽  
Compulsive Disorder

The current study examined the efficacy of cognitive therapy (CT) in reducing symptoms of obsessive-compulsive disorder (OCD). Twenty-nine individuals with OCD were assigned according to therapist availability to a 12-week wait period or the immediate start of 22 sessions (over 24 weeks) of flexible, modular CT. After 12 weeks of treatment, the CT group, but not the wait-list group, exhibited significant improvement in OCD symptoms. The combined sample of patients who underwent 24 weeks of CT improved significantly from pre- to post-treatment and symptoms remained significantly improved at 3-month follow-up. OCD symptoms rose slightly between post-treatment and 12-month follow-up, but, remained significantly lower than at pretreatment. Overall, modular CT appears to be an effective and acceptable treatment for OCD.

scholarly journals Mindfulness-Based Cognitive Therapy for Unmedicated Obsessive-Compulsive Disorder: A Randomized Controlled Trial With 6-Month Follow-Up

2021 ◽  
Vol 12 ◽  
Author(s):  
Tianran Zhang ◽  
Lu Lu ◽  
Fabrizio Didonna ◽  
Zhen Wang ◽  
Haiyin Zhang ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Cognitive Therapy ◽  
Obsessive Compulsive Disorder ◽  
Controlled Trial ◽  
Treatment Acceptability ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Randomized Controlled ◽  
Treatment Responses

Background: This was the first randomized controlled trial (RCT) designed to compare the efficacy of mindfulness-based cognitive therapy (MBCT) on unmedicated obsessive-compulsive disorder with that of the first-line treatment for OCD (SSRIs) or a placebo, as well as to analyze the treatment acceptability and safety of MBCT.Methods: A total of 123 unmedicated OCD patients with mild to moderate symptoms were randomly assigned into selective serotonin reuptake inhibitors group (SSRIs group), MBCT group or psycho-education group (PE group), respectively. They were intervened for 10 weeks. The Yale–Brown Obsessive-Compulsive Scale (Y-BOCS) grade was the primary outcome, and Hamilton Depression Scale-24 (HAMD-24) and Hamilton Anxiety Scale (HAMA) grades were secondary outcomes to be measured at baseline, mid-intervention, post-intervention and 14, 22, and 34 weeks of follow-up. The Five Facet Mindfulness Questionnaire (FFMQ) and Sheehan Disability Scale (SDS) were used to assess mindfulness and social functions, respectively. In addition, treatment acceptability (dropout rate and frequency of occurrence) and safety [adverse event (AE)] of MBCT were investigated.Results: Significant differences were detected in the treatment responses among SSRIs group, MBCT group and PE group. Notably, treatment responses were significantly better in the former two groups than that of PE group (χ2 = 6.448, p = 0.04), although we did not identify significant differences between SSRIs group and MBCT group (χ2 = 1.220, p = 0.543). Observed until 6 months of follow-up, there were no significant differences in treatment response among three groups. No AE was recorded in MBCT group.Conclusion: MBCT is effective in the treatment of unmedicated OCD with mild to moderate symptoms comparable to that of SSRIs, which contributes to maintain the treatment outcomes at follow-up. Besides, MBCT is safe with a good clinical compliance.

Mindfulness-based cognitive therapy for obsessive-compulsive disorder: Study protocol for a randomized controlled trial with functional magnetic resonance imaging and a 6-month follow-up

2018 ◽  
Vol 25 (13-14) ◽  
pp. 2072-2084 ◽  
Author(s):  
Lu Lu ◽  
Tianran Zhang ◽  
Rui Gao ◽  
Zongfeng Zhang ◽  
Xuan Cao ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Cognitive Therapy ◽  
Obsessive Compulsive Disorder ◽  
Controlled Trial ◽  
Functional Magnetic Resonance ◽  
Resonance Imaging ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Randomized Controlled

This article presents a study protocol for a single-blind randomized controlled trial to test the efficacy and feasibility of mindfulness-based cognitive therapy. A total of 120 un-medicated Chinese obsessive-compulsive disorder patients will be randomized to the mindfulness-based cognitive therapy group, the selective serotonin reuptake inhibitor group or the psycho-education group for 11 sessions in 10 weeks. A range of scales for clinical symptoms and functional magnetic resonance imaging will be completed at baseline (week 0), mid-intervention (week 4), post-intervention (week 10) and the 6-month follow-up (weeks 14, 22 and 34). The study will have relevance to decisions about treatment options for un-medicated obsessive-compulsive disorder patients.

Group Versus Individual Cognitive Treatment for Obsessive-Compulsive Disorder: Changes in Severity at Post-Treatment and One-Year Follow-up

2009 ◽  
Vol 38 (2) ◽  
pp. 227-232 ◽  
Author(s):  
Elena Cabedo ◽  
Amparo Belloch ◽  
Carmen Carrió ◽  
Christina Larsson ◽  
Héctor Fernández-Alvarez ◽  
...  
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Post Treatment ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Cognitive Behaviour ◽  
One Year ◽  
The One ◽  
The Individual ◽  
Group Cbt

Background: Very few studies have compared the efficacy of individual and group cognitive behaviour therapy (CBT) for the treatment of Obsessive-Compulsive Disorder (OCD) by taking into consideration the change in OCD severity in both the short and long term. Aims: To conduct an open trial of individual versus group CBT for OCD, comparing the clinical and statistically significant changes in severity both at post-treatment and one year later. Method: Forty-two OCD subjects were assigned to individual (n = 18) or group CBT (n = 24, in four groups). Sixteen and 22 subjects completed the treatment in the individual and group conditions, respectively. The Yale-Brown Obsessive Compulsive Scale was recorded at pre-treatment, post-treatment and at the one-year follow-up. Results: At the end of treatment, the clinically significant change was comparable for the two treatment conditions and remained stable at the one-year follow-up. Of the 16 participants who completed the individual CBT treatment, 68.75% were classified as recovered at post-treatment, compared to 40.9% of those receiving group CBT. At follow-up the rate of recovery decreased to 62.5% in individual CBT and to 31.8% in group CBT. Conclusions: Group CBT is effective in decreasing OCD severity. The post-treatment changes were maintained one year later. Nevertheless, these changes were higher in the individual delivery of CBT.

Group versus individual cognitive treatment for Obsessive-Compulsive Disorder: Changes in non-OCD symptoms and cognitions at post-treatment and one-year follow-up

2011 ◽  
Vol 187 (1-2) ◽  
pp. 174-179 ◽  
Author(s):  
Amparo Belloch ◽  
Elena Cabedo ◽  
Carmen Carrió ◽  
Héctor Fernández-Alvarez ◽  
Fernando García ◽  
...  
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Group Versus ◽  
Post Treatment ◽  
Obsessive Compulsive ◽  
Cognitive Treatment ◽  
Compulsive Disorder ◽  
One Year

scholarly journals Does Concentrated Exposure Treatment for Obsessive-Compulsive Disorder Improve Insomnia Symptoms? Results From a Randomized Controlled Trial

2021 ◽  
Vol 12 ◽  
Author(s):  
Kristen Hagen ◽  
Håkon Nordahl ◽  
Gunvor Launes ◽  
Gerd Kvale ◽  
Lars-Göran Öst ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Obsessive Compulsive Disorder ◽  
Day Treatment ◽  
Controlled Trial ◽  
Obsessive Compulsive ◽  
Exposure Treatment ◽  
Compulsive Disorder ◽  
Randomized Controlled ◽  
Substantial Problem

Insomnia is a substantial problem in patients with obsessive-compulsive disorder (OCD). There is, however, a lack of studies investigating changes in concurrent symptoms of insomnia in OCD after concentrated treatment. A recent randomized controlled trial randomized participants to the Bergen 4-day treatment (B4DT, n = 16), or 12 weeks of unguided self-help (SH, n = 16), or waitlist (WL, n = 16). Patients from the SH- and WL-group who wanted further treatment after the 12 weeks were then offered the B4DT (total of 42 patients treated with the B4DT). There were no significant differences in symptoms of insomnia between the conditions at post-treatment, but a significant moderate improvement at 3-month follow-up for patients who received the B4DT. Insomnia was not associated with OCD-treatment outcome, and change in symptoms of insomnia was mainly related to changes in depressive symptoms. The main conclusion is that concentrated exposure treatment is effective irrespective of comorbid insomnia, and that insomnia problems are moderately reduced following treatment.

scholarly journals Treated depression in adolescents: predictors of outcome at 28 weeks

2009 ◽  
Vol 194 (4) ◽  
pp. 334-341 ◽  
Author(s):  
Paul Wilkinson ◽  
Bernadka Dubicka ◽  
Raphael Kelvin ◽  
Chris Roberts ◽  
Ian Goodyer
Keyword(s):  
Major Depression ◽  
Obsessive Compulsive Disorder ◽  
Selective Serotonin Reuptake Inhibitors ◽  
Adolescent Depression ◽  
Controlled Trial ◽  
Psychosocial Care ◽  
Behavioural Therapy ◽  
Obsessive Compulsive ◽  
Compulsive Disorder

BackgroundThere is great heterogeneity of clinical presentation and outcome in paediatric depression.AimsTo identify which clinical and environmental risk factors at baseline and during treatment predicted major depression at 28-week follow-up in a sample of adolescents with depression.MethodOne hundred and ninety-two British adolescents with unipolar major depression were enrolled in a randomised controlled trial (the Adolescent Depression Antidepressants and Psychotherapy Trial, ADAPT). Participants were treated for 28 weeks with routine psychosocial care and selective serotonin reuptake inhibitors (SSRIs), with half also receiving cognitive–behavioural therapy (CBT). Full clinical and demographic assessment was carried out at baseline and 28 weeks.ResultsDepression at 28 weeks was predicted by the additive effects of severity, obsessive–compulsive disorder and suicidal ideation at entry together with presence of at least one disappointing life event over the follow-up period.ConclusionsClinicians should assess for severity, suicidality and comorbid obsessive–compulsive disorder at presentation and should monitor closely for subsequent life events during treatment.

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