scholarly journals Evaluation, hallmark, clinical relevance and role of anti citrullin antibody, IgG and IgM rheumatoid factor with serological parameters of disease activity or both as overall sifted test in undifferentiated seronegative arthropathy with or without joint inflammation and bone structure differences. Boost, over helling or amplification to classification criteria to rheumathoid arthritis?

2016 ◽  
Vol 1 (2) ◽  
Author(s):  
Dejan Spasovski
Keyword(s):  
Disease Activity ◽  
Rheumatoid Factor ◽  
Clinical Relevance ◽  
Bone Structure ◽  
Joint Inflammation ◽  
Classification Criteria ◽  
Igm Rheumatoid Factor

scholarly journals A spontaneous rheumatoid arthritis-like disease in MRL/l mice.

1982 ◽  
Vol 155 (6) ◽  
pp. 1690-1701 ◽  
Author(s):  
L Hang ◽  
A N Theofilopoulos ◽  
F J Dixon
Keyword(s):  
Rheumatoid Arthritis ◽  
Rheumatoid Factor ◽  
Joint Inflammation ◽  
Close Correlation ◽  
Human Rheumatoid Arthritis ◽  
Igm Rheumatoid Factor ◽  
Joint Pathology ◽  
Old Females

MRL/l mice spontaneously develop an arthritis very similar in many respects to human rheumatoid arthritis. A detailed morphologic and serologic analysis of this disease revealed the following: (a) a 75% incidence of synovial and periarticular inflammation, very similar to human rheumatoid arthritis, in 5-6 mo-old females, (b) close associations between presence of joint inflammation and subsynovial and/or periarticular vasculitis, and (c) a close correlation between presence of circulating IgM rheumatoid factor (RF) and demonstrable synovial and/or joint pathology, i.e., 95% of mice with significant levels of IgMRF had synovitis and/or arthritis.

scholarly journals Rheumatoid Arthritis Patients With Circulating Extracellular Vesicles Positive for IgM Rheumatoid Factor Have Higher Disease Activity

2018 ◽  
Vol 9 ◽  
Author(s):  
Onno J. Arntz ◽  
Bartijn C. H. Pieters ◽  
Rogier M. Thurlings ◽  
Mark H. Wenink ◽  
Peter L. E. M. van Lent ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Disease Activity ◽  
Rheumatoid Factor ◽  
Extracellular Vesicles ◽  
Igm Rheumatoid Factor

scholarly journals Rethink about the role of rheumatoid factor and anti-citrullinated protein antibody in rheumatoid arthritis

2021 ◽  
Vol 2 (1) ◽  
pp. 19-25
Author(s):  
Wang Yu Sung ◽  
Wen Chan Tsai
Keyword(s):  
Rheumatoid Arthritis ◽  
Rheumatoid Factor ◽  
Immune Cells ◽  
Joint Inflammation ◽  
Review Article ◽  
Disease Spectrum ◽  
Inflammatory Autoimmune Disease ◽  
Citrullinated Protein ◽  
Chronic Inflammatory Autoimmune Disease

Abstract Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease characterized by joint inflammation and extra-articular manifestations. Many questions in the pathogenesis, clinical manifestation, and disease spectrum are answered after the discovery of the first autoantibody namely rheumatoid factor (RF). The finding of the second autoantibody named anti-citrullinated protein antibody (ACPA), which unearths the importance of protein citrullination process. It further provides the insight how immune cells and complement interact to perpetuate the inflammatory response. These two autoantibodies pave the way for our better understanding of RA. This review article focuses on the history, pathophysiology, and clinical association of these two autoantibodies in RA.

scholarly journals The role of ultrasonography in assessing disease activity in patients with rheumatoid arthritis and associated fibromyalgia

2015 ◽  
Vol 17 (3) ◽  
pp. 339 ◽  
Author(s):  
Linda Jessica Ghib ◽  
Maria Magdalena Tamas ◽  
Laura Otilia Damian ◽  
Ioana Felea ◽  
Laura Mirela Muntean ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Disease Activity ◽  
Disease Activity Score ◽  
Power Doppler ◽  
Classification Criteria ◽  
Control Groups ◽  
Das28 Score ◽  
Grey Scale ◽  
Fluid Collections

Aim: The purpose of this study is to compare and correlate US evaluation with clinical scores of the disease activity in patients with rheumatoid arthritis (RA) and concomitant fibromyalgia (FM). Material and methods: Ten patients diagnosed with RA according to the 2010 ACR/EULAR classification criteria and associated FM based on the ACR 1990 classification criteria and two control groups, one with RA (10 patients) and one with FM (10 patients), were included. Clinical assessment was performed and the disease activity scores were calculated. Synovial/tenosynovial hypertrophy, fluid collections in grey scale (GS), and Power Doppler (PD) US assessed by US in the 28 joints included in the disease activity score 28 (DAS28). Results: GS US score and PD US scores were correlated with DAS28 only in patients with RA (Pearson r coefficients 0.3 and 0.5). Mean DAS28 score was significantly higher in the RA/FM group, compared to RA and FM (5.6 versus 4.6 versus 4.5, respectively). Patients with RA/FM had similar median US scores to RA patients, while in FM group significantly lower median US scores were detected (16 versus 9.5 versus 0 for GS US and 3.5 versus 1.5 versus 0 for PD US, respectively). Con- clusions: Disease activity scores should be interpreted with caution in patients with RA and FM. When available, US should be used to guide treatment decisions in patients with RA and FM.

Role of 14-3-3η (Eta) Protein as Immunological Marker for Disease Activity in Patients with Rheumatoid Arthritis

2020 ◽  
Vol 11 (2) ◽  
pp. 2234
Author(s):  
Muhannad Mohammed Ali AL-Salami ◽  
Abeer Thaher Naji AL-Hasnawi ◽  
Mohammed Abd AbdulHussein Abusabe
Keyword(s):  
Rheumatoid Arthritis ◽  
Disease Activity ◽  
Immunological Marker

Immunoregulatory Role of Interleukin-37 in Rheumatoid Arthritis; Relation to Disease Activity and Joint Destruction

2018 ◽  
Vol 86 (September) ◽  
pp. 3341-3348
Author(s):  
DALIA B. EL-BOHOTY, M.Sc.; DOAA S. AL-ASHKAR, M.D. ◽  
MAALY M. MABROUK, M.D.; HALA M. NAGY, M.D.
Keyword(s):  
Rheumatoid Arthritis ◽  
Disease Activity ◽  
Joint Destruction

Evaluating the efficacy of intra-articular injections of platelet rich plasma (PRP) in rheumatoid arthritis patients and its impact on inflammatory cytokines, disease activity and quality of life.

2020 ◽  
Vol 16 ◽  
Author(s):  
Dalia S. Saif ◽  
Nagwa N. Hegazy ◽  
Enas S. Zahran
Keyword(s):  
Quality Of Life ◽  
Rheumatoid Arthritis ◽  
Disease Activity ◽  
Inflammatory Cytokines ◽  
Platelet Rich Plasma ◽  
Joint Inflammation ◽  
Monthly Interval ◽  
Post Injection ◽  
Tnf Α

Background: Among rheumatoid arthritis patients (RA), general disease activity is well regulated by diseasemodifying anti-rheumatic medications (DMARDS), but sometimes local inflammation still persists among a few joints. Adjuvant modern molecular interventions as Platelet Rich Plasma (PRP) with a suggested down regulating effect on inflammatory mediators has a proven effect in management of RA. We aim to evaluate the therapeutic effect of intra-articular PRP versus steroid in RA patients and their impact on inflammatory cytokines IL1B , TNF α, local joint inflammation, disease activity and quality of life (QL). Methods: Open labeled parallel randomized control clinical trial was carried out on 60 RA patients randomly divided into 2 groups, Group 1: included 30 patients received 3 intra-articular injections of PRP at monthly interval, Group 2: included 30 patients received single intra-articular injection of steroid. They were subjected to clinical, laboratory, serum IL1B and TNF α assessment at baseline and at 3, 6 months post injection. Results: Patients of both groups showed improvements in their scores of evaluating tools at 3months post injection and this improvement was persistent in the PRP group up to 6 months post injection while it was continued only for 3 months in the steroid group. Conclusions: PRP is a safe, effective and useful therapy in treating RA patients who had insufficient response and persistent pain and inflammation in just one or two joints through its down regulating effect on inflammatory cytokines IL1B, TNF α with subsequent improvement of local joint inflammation, disease activity and QL.

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