scholarly journals Performance of Aluminium Hydroxide Gel and ISA Oils Adjuvanted Foot and Mouth Disease Vaccines

2019 ◽  
Vol 5 (3) ◽  
Keyword(s):  
Aluminium Hydroxide ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Foot And Mouth ◽  
Aluminium Hydroxide Gel

scholarly journals Evaluation of different adjuvants for foot-and-mouth disease vaccine containing all the SAT serotypes

2008 ◽  
Vol 75 (1) ◽  
Author(s):  
M. Cloete ◽  
B. Dungu ◽  
L.I. Van Staden ◽  
N. Ismail-Cassim ◽  
W. Vosloo
Keyword(s):  
South African ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Virus Challenge ◽  
Free Zone ◽  
Homologous Virus ◽  
Foot And Mouth ◽  
Virulent Virus ◽  
Aluminium Hydroxide Gel ◽  
Sat 1

Foot-and-mouth disease (FMD) is an economically important disease of cloven-hoofed animals that is primarily controlled by vaccination of susceptible animals and movement restrictions for animals and animal-derived products in South Africa. Vaccination using aluminium hydroxide gel-saponin (AS) adjuvanted vaccines containing the South African Territories (SAT) serotypes has been shown to be effective both in ensuring that disease does not spread from the endemic to the free zone and in controlling outbreaks in the free zone. Various vaccine formulations containing antigens derived from the SAT serotypes were tested in cattle that were challenged 1 year later. Both the AS and ISA 206B vaccines adjuvanted with saponin protected cattle against virulent virus challenge. The oilbased ISA 206B-adjuvanted vaccine with and without stimulators was evaluated in a field trial and both elicited antibody responses that lasted for 1 year. Furthermore, the ISA 206 adjuvanted FMD vaccine protected groups of cattle against homologous virus challenge at very low payloads, while pigs vaccinated with an emergency ISA 206B-based FMD vaccine containing the SAT 1 vaccine strains were protected against the heterologous SAT 1 outbreak strain.

scholarly journals The use of acetylethyleneimine in the production of inactivated foot-and-mouth disease vaccines

1963 ◽  
Vol 61 (3) ◽  
pp. 337-344 ◽  
Author(s):  
F. Brown ◽  
N. St G. Hyslop ◽  
Joan Crick ◽  
A. W. Morrow
Keyword(s):  
Aluminium Hydroxide ◽  
Serum Antibody ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Serum Neutralization ◽  
Fmd Virus ◽  
Foot And Mouth

Suspensions of FMD virus treated with 0·05% formalin at 26° C. for periods up to 144 hr. remained infective for cattle, although the infectivity could not be detected in the presence of aluminium hydroxide. Infectivity was detected in similar virus suspensions which had been treated with 0·05% AEI at 37° C. for 8 hr. but not in suspensions treated for 12 hr.Vaccines prepared from these suspensions were antigenically potent and serum neutralization tests demonstrated the development and regression of serum antibody. The AEI vaccines were at least as potent as the corresponding formalin vaccines.

Biophysical Measurement of Molecular Weight of Foot-and-Mouth Disease RNA Fragments

1974 ◽  
Vol 32 ◽  
pp. 262-263
Author(s):  
Sydney S. Breese ◽  
Howard L. Bachrach
Keyword(s):  
Chemical Properties ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Distilled Water ◽  
Bovine Plasma ◽  
Mouth Disease Virus ◽  
Foot And Mouth ◽  
Carbon Coated ◽  
Rna Fragments ◽  
Physical And Chemical

Continuing studies on the physical and chemical properties of foot-and-mouth disease virus (FMDV) have included electron microscopy of RNA strands released when highly purified virus (1) was dialyzed against demlneralized distilled water. The RNA strands were dried on formvar-carbon coated electron microscope screens pretreated with 0.1% bovine plasma albumin in distilled water. At this low salt concentration the RNA strands were extended and were stained with 1% phosphotungstic acid. Random dispersions of strands were recorded on electron micrographs, enlarged to 30,000 or 40,000 X and the lengths measured with a map-measuring wheel. Figure 1 is a typical micrograph and Fig. 2 shows the distributions of strand lengths for the three major types of FMDV (A119 of 6/9/72; C3-Rezende of 1/5/73; and O1-Brugge of 8/24/73.

High resolution surface structure of foot-and-mouth disease virus

1978 ◽  
Vol 36 (2) ◽  
pp. 376-377
Author(s):  
S. S. Breese ◽  
H. L. Bachrach
Keyword(s):  
Electron Microscopy ◽  
High Resolution ◽  
Surface Structure ◽  
Disease Virus ◽  
Potassium Phosphate ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Physical Measurements ◽  
Mouth Disease Virus ◽  
Foot And Mouth

Models for the structure of foot-and-mouth disease virus (FMDV) have been proposed from chemical and physical measurements (Brown, et al., 1970; Talbot and Brown, 1972; Strohmaier and Adam, 1976) and from rotational image-enhancement electron microscopy (Breese, et al., 1965). In this report we examine the surface structure of FMDV particles by high resolution electron microscopy and compare it with that of particles in which the outermost capsid protein VP3 (ca. 30, 000 daltons) has been split into smaller segments, two of which VP3a and VP3b have molecular weights of about 15, 000 daltons (Bachrach, et al., 1975).Highly purified and concentrated type A12, strain 119 FMDV (5 mg/ml) was prepared as previously described (Bachrach, et al., 1964) and stored at 4°C in 0. 2 M KC1-0. 5 M potassium phosphate buffer at pH 7. 5. For electron microscopy, 1. 0 ml samples of purified virus and trypsin-treated virus were dialyzed at 4°C against 0. 2 M NH4OAC at pH 7. 3, deposited onto carbonized formvar-coated copper screens and stained with phosphotungstic acid, pH 7. 3.

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