scholarly journals Bilateral Warthin’s tumor with a fibrous variant of chronic lymphocytic thyroiditis misdiagnosed as well-differentiated thyroid cancer with lymph node metastasis

2019 ◽  
Author(s):  
Krzysztof Kaliszewski ◽  
Anna Brona ◽  
Paweł Gajdzis ◽  
Anna Otlewska ◽  
Krzysztof Sutkowski
Keyword(s):  
Thyroid Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Differentiated Thyroid Cancer ◽  
Chronic Lymphocytic Thyroiditis ◽  
Warthin’S Tumor ◽  
Lymphocytic Thyroiditis ◽  
Node Metastasis ◽  
Warthin's Tumor ◽  
Well Differentiated

The Implication of Lymph Node Metastasis on Survival in Patients with Well-Differentiated Thyroid Cancer

2005 ◽  
Vol 71 (9) ◽  
pp. 731-734 ◽  
Author(s):  
Yale D. Podnos ◽  
David Smith ◽  
Lawrence D. Wagman ◽  
Joshua D.I. Ellenhorn
Keyword(s):  
Thyroid Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Tumor Size ◽  
Large Scale ◽  
Differentiated Thyroid Cancer ◽  
Lymph Node Status ◽  
Large Tumor ◽  
Node Metastasis ◽  
Well Differentiated

Though survival for well-differentiated thyroid cancer is very good, specific populations suffer greater recurrence and mortality. Defining these cohorts can significantly influence prognosis and extent of treatment. This study, using a large, multi-institutional database, seeks to determine how the presence of lymph node disease in patients with well-differentiated thyroid cancer affects outcome. The Surveillance, Epidemiology, and End Results (SEER) database is a large-scale sample of 14 per cent of the U.S. population. It was used to identify patients with papillary and follicular thyroid carcinomas and identify the prognostic implications of lymph node metastasis. Additional factors, including presence of metastasis, age, and tumor size, were compared using multivariate and χ2 analyses. Of 19,918 patients identified, lymph node status was known for 9,904 (49.7%). On multivariate analysis, age >45 years, presence of distant metastasis, large tumor size, and lymph node involvement significantly predicted poor outcome. Overall survival at 14 years was 82 per cent for node negative and 79 per cent for node positive patients ( P < 0.05). This study shows that the survival of patients with well-differentiated thyroid cancer is adversely affected by lymph node metastases. The optimum treatment for this cohort needs further delineation, as particular populations are at greater risk of recurrence and death.

Significance of lymph node metastasis in differentiated thyroid cancer

1978 ◽  
Vol 136 (1) ◽  
pp. 107-112 ◽  
Author(s):  
James Harwood ◽  
Orlo H. Clark ◽  
J.Englebert Dunphy
Keyword(s):  
Thyroid Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Differentiated Thyroid Cancer ◽  
Node Metastasis

scholarly journals Usefulness of Pre-Thyroidectomy Neutrophil-Lymphocyte, Platelet-Lymphocyte, and Monocyte-Lymphocyte Ratios in Discriminating Lymph Node and Distant Metastases in Differentiated Thyroid Cancer

2021 ◽  
Author(s):  
Cinthia Minatel Riguetto ◽  
Icléia Siqueira Barreto ◽  
Frederico Fernandes Ribeiro Maia ◽  
Ligia Vera Montali da Assumpção ◽  
Denise Engelbrecht Zantut-Wittmann
Keyword(s):  
Thyroid Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Distant Metastasis ◽  
Differentiated Thyroid Cancer ◽  
Response To Therapy ◽  
Lymphocyte Ratio ◽  
Node Metastasis ◽  
Disease Free ◽  
Active Disease

Abstract Purpose This study aims to show the relationship between neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR) and monocyte-lymphocyte ratio (MLR), with clinicopathological characteristics in patients with differentiated thyroid cancer (DTC). Methods This is a retrospective study involving 390 DTC patients who had complete blood cell count available at the time of the surgery. NLR, PLR, and MLR were calculated, risk of cancer-related death, structural recurrence, and response to therapy were assessed by the 8th edition of the tumor-node-metastasis (TNM), American Thyroid Association (ATA) Risk Stratification System, and ATA Response to Therapy Reclassification, respectively. Results PLR was higher in distant metastasis (133.15±43.95 vs 119.24±45.69, p = 0.0345), lower in disease-free versus persistent disease or death (117.72±44.70 vs 131.07±47.85, p = 0.0089). In MLR, patients ≥55 had a higher score than < 55 years old (0.26±0.10 vs 0.24±0.12, p = 0.0379). Higher MLR (OR 8.775; 95% CI = 1.532–50.273; p = 0.0147), intermediate (OR 4.892; 95% CI = 2.492–9.605; p ≤ 0.0001) and high ATA risks (OR 5.998; 95% CI = 3.126–11.505; p ≤ 0.0001) were risk factors associated with active disease. NLR was not significant. ROC curve cut-off values for NLR, PLR, and MLR were able to discriminate distant from lymph node metastasis (NLR > 1.93 sensitivity 73.3%, specificity 58.7%; PLR > 124.34 sensitivity 86.7%, specificity 69.2%; MLR > 0.21 sensitivity 80%, specificity 45.2%). Conclusion Cut-off values of NLR, PLR, and MLR discriminated the presence of distant metastasis from lymph node metastasis with good sensitivity and accuracy. PLR was an associated factor with disease-free status and higher in DTC patients with distant metastasis, persistency, and disease-related death. MLR was a risk factor of active disease.

scholarly journals Comparison of 18F-AIF-NOTA-PRGD2 and 18F-FDG Uptake in Lymph Node Metastasis of Differentiated Thyroid Cancer

PLoS ONE ◽  
2014 ◽  
Vol 9 (6) ◽  
pp. e100521 ◽  
Author(s):  
Weiwei Cheng ◽  
Zhenyu Wu ◽  
Sheng Liang ◽  
Hongliang Fu ◽  
Shuqi Wu ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Differentiated Thyroid Cancer ◽  
Fdg Uptake ◽  
Node Metastasis ◽  
18F Fdg
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