scholarly journals Nonalcoholic fatty liver disease and the risk of metabolic comorbidities: how to manage in clinical practice

Author(s):  
Carolina Perdomo ◽  
Paola D’Ingianna ◽  
Javier Escalada ◽  
Salvatore Petta ◽  
Manuel Romero Gómez ◽  
...  
2021 ◽  
Vol 51 (10) ◽  
pp. 1013-1025
Author(s):  
Katsutoshi Tokushige ◽  
Kenichi Ikejima ◽  
Masafumi Ono ◽  
Yuichiro Eguchi ◽  
Yoshihiro Kamada ◽  
...  

2015 ◽  
Vol 45 (4) ◽  
pp. 363-377 ◽  
Author(s):  
Sumio Watanabe ◽  
Etsuko Hashimoto ◽  
Kenichi Ikejima ◽  
Hirofumi Uto ◽  
Masafumi Ono ◽  
...  

2017 ◽  
Vol 32 (4) ◽  
pp. 397-402 ◽  
Author(s):  
Luca Miele ◽  
Teresa De Michele ◽  
Giuseppe Marrone ◽  
Maria Antonietta Isgrò ◽  
Umberto Basile ◽  
...  

Background Liver fibrosis is the main determinant and predictor of the clinical course of nonalcoholic fatty liver disease (NAFLD). To date, a liver biopsy is still considered the gold standard for staging fibrosis. The aim of this study was to investigate the diagnostic accuracy of the commercial enhanced liver fibrosis (ELF) test manufacturer's cutoff value (≥9.8) in identifying severe fibrosis for adult patients with histologically confirmed NAFLD. Methods We tested the ELF test in a clinical practice, prospective cohort of 82 consecutive patients who consecutively underwent percutaneous liver biopsy. Results All stages of liver fibrosis were represented in our cohort, and severe fibrosis was present in 15 of 82 patients (18.3%). The stage of fibrosis was significantly associated with ELF score (Spearman's rho = 0.483, p<0.001). The commercial ELF test manufacturer's cutoff identified severe fibrosis with good sensitivity (86.7%; 95% confidence interval [95% CI], 0.69-1.04) and high specificity (92.5%; 95% CI, 0.86-0.99), with a positive predictive value of 72% and negative predictive value of 97%. Conclusions Our data could support the use of the ELF test in clinical practice.


2017 ◽  
Vol 15 (12) ◽  
pp. 1968-1971 ◽  
Author(s):  
Leah Avery ◽  
Catherine Exley ◽  
Stuart McPherson ◽  
Michael I. Trenell ◽  
Quentin M. Anstee ◽  
...  

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