scholarly journals Henoch-Schönlein Purpura: Management and Complication

2020 ◽  
Vol 3 (2) ◽  
pp. 113
Author(s):  
Radhitya Farizky Deta Juniawan ◽  
Awalia Awalia
Keyword(s):  
Plasma Cells ◽  
Clinical Manifestations ◽  
Supportive Therapy ◽  
Henoch Schonlein Purpura ◽  
Cutaneous Manifestations ◽  
Male Patients ◽  
Low Incidence ◽  
Almost All ◽  
Schonlein Purpura ◽  
Henoch Schönlein Purpura

Henoch-Schönlein Purpura (HSP) is a disease that mainly affects children, while the incidence in adults is rarely reported. Low incidence in adults caused by undiagnosed or misdiagnosed. Course of the disease in adults is more complex, including high incidence of renal insufficiency. Renal manifestations need special attention because it can worsen the prognosis, so patients must be detected and treated as quickly as possible. Poor prognosis depends on the presence of renal clinical manifestations accompanied by an increase in the severity of renal histological grading, abdominal manifestations, and persistent purpura. We describe male patients with HSP, presenting with gastrointestinal, renal, and cutaneous manifestations. Gastroscopy showed superficial gastritis (reddish patches on almost all gastric mucosa. Skin biopsy showed lymphocytic vasculitis. Gastric biopsy shows infiltration of lymphocyte inflammation cells, histiocytes, plasma cells in the corpus and gastric antrum. Patients have received supportive therapy, steroid, and showed clinical improvement.

Epidemiological Study of Henoch-Schonlein Purpura and its Characteristics in Infected Children During 2009-2016

2021 ◽  
Vol 15 (6) ◽  
pp. 1629-1633
Author(s):  
Sadegh Dehghanmehr ◽  
Reza Naghdi ◽  
Farahnaz Irandegani ◽  
Hamed Taheri ◽  
Omar Pourbalouch ◽  
...  
Keyword(s):  
Clinical Manifestations ◽  
Cross Sectional Study ◽  
Additional Treatment ◽  
Henoch Schonlein Purpura ◽  
Cross Sectional ◽  
Cutaneous Manifestations ◽  
The Mean ◽  
Autumn And Winter ◽  
Schonlein Purpura ◽  
Henoch Schönlein Purpura

Introduction: Due to the different complications caused by Henoch-Schonlein purpura and in order to prevent additional treatment costs for patients, we decided to investigate the clinical features of cases of Henoch-Schonlein purpura. Materials and Methods: In this descriptive cross-sectional study, 52 children in whom the diagnosis of Henoch-Schonlein purpura was confirmed were enrolled in the study from 2009 to 2016. The instruments of this research include a researcher-made questionnaire with two parts. The first part is related to demographic characteristics including age, sex and season of referral and the second part was related to morbidity such as various symptoms. Data were collected from patients’ records and interviews with families and were analyzed using SPSS V.22. Results: Out of 52 patients, 30 (57.7%) were boys and 22 (43.3%) were girls. The mean age of patients was 3.02 to 6.58 years. Autumn and winter had the most clients of Henoch-Schonlein purpura. One of the most common manifestations seen in most patients was cutaneous manifestations. There was no significant relationship between gender and clinical manifestations and seasons of the year with these manifestations (p> 0.05). The results showed that age was significantly associated with renal manifestations (P <0.05). Conclusion: The results of this study showed that the prevalence of Henoch-Schonlein purpura disease is higher in boys. Cutaneous manifestations were seen in most patients and in patients with renal manifestations, the mean age was higher and significant. Keywords: Henoch-Schonlein purpura, clinical manifestations, complications, gender, age

Clinical Manifestations of Korean Adult Patients with Henoch-Schönlein Purpura

2010 ◽  
Vol 17 (2) ◽  
pp. 133 ◽  
Author(s):  
Yoon Kang ◽  
You-Jung Ha ◽  
Kwang-Hoon Lee ◽  
Sang-Youn Jung ◽  
Sang-Won Lee ◽  
...  
Keyword(s):  
Clinical Manifestations ◽  
Adult Patients ◽  
Henoch Schonlein Purpura ◽  
Korean Adult ◽  
Schonlein Purpura ◽  
Henoch Schönlein Purpura

scholarly journals Why does Mycophenolate use only for kidney complications in Schonlein Henoch Syndrome? Case report

2020 ◽  
Author(s):  
Maria Francesca Gicchino ◽  
Dario Iafusco ◽  
Maria Maddalena Marrapodi ◽  
Rosa Melone ◽  
Giovanna Cuomo ◽  
...  
Keyword(s):  
Abdominal Pain ◽  
Mycophenolate Mofetil ◽  
Immunosuppressive Agents ◽  
Renal Involvement ◽  
Lower Extremities ◽  
Gastrointestinal Involvement ◽  
Henoch Schonlein Purpura ◽  
Cutaneous Manifestations ◽  
Schonlein Purpura ◽  
Henoch Schönlein Purpura

Abstract Background : Henoch Schonlein purpura (HSP) is an acute small vessel vasculitis. It is the most common vasculitis in children. Although the cause is unknown, IgA seems to play a central role in the pathogenesis of Henoch Schonlein purpura. The major clinical features include a palpable purpuric rash on the lower extremities, abdominal pain or renal involvement, and arthritis. Cutaneous manifestations are the essential elements in the diagnosis of Henoch Schonlein purpura. The palpable purpura is characteristically 2 to 10mm in diameter and is usually present on the lower extremities. There are no specific diagnostic tests available for diagnosing this condition. Laboratory studies are useful to exclude other conditions that may mimic Henoch Schonlein purpura. In majority of the cases, the disease is self-limited. Relapsing can occur, in particular during the first year of the disease. There is no consensus on a specific treatment. Corticosteroids are effective in rapid resolution of renal and abdominal manifestations. Immunosuppressive drugs, such as Mycophenolate Mofetil may be a better treatment choice in case of renal involvement.Case report : We report a case of a 14 years old girl affected from recurrent Henoch Schonlein Purpura. From the age of nine years patient presented three episodes of purpura with gastrointestinal involvement, in particular hematemesis, abdominal pain and diarrhoea. Each episode was treated with high doses of corticosteroids (methylprednisolone in vein or prednisone per os). Patient came to our Department during the third episode of Purpura. In consideration of the recurrence of the Henoch Schonlein Purpura and the gastrointestinal involvement we decided to start Mycophenolate Mofetil treatment. Patient’s conditions improved thanks to Mycophenolate Mofetil treatment. Conclusion: In our case of recurrent HSP Mycophenolate Mofetil treatment has been very effective, avoiding the adverse events of a prolonged steroid treatment. This experience teaches us that immunosuppressive agents may be very useful to induce and maintain remission not only in renal involvement, but in all cases of persistence, recurrence or complicated forms of Henoch Schonlein purpura in children.

Clinical manifestations and outcomes of 420 children with Henoch Schönlein Purpura from a single referral center from Turkey: A three-year experience

2019 ◽  
Vol 30 (6) ◽  
pp. 1039-1046 ◽  
Author(s):  
Rabia Miray Kisla Ekinci ◽  
Sibel Balci ◽  
Engin Melek ◽  
Aysun Karabay Bayazit ◽  
Dilek Dogruel ◽  
...  
Keyword(s):  
Clinical Manifestations ◽  
Henoch Schonlein Purpura ◽  
Referral Center ◽  
Schonlein Purpura ◽  
Henoch Schönlein Purpura

scholarly journals Clinical Manifestations and Outcomes of Henoch-Schönlein Purpura: Comparison between Adults and Children

2009 ◽  
Vol 50 (4) ◽  
pp. 162-168 ◽  
Author(s):  
Shih-Pin Hung ◽  
Yao-Hsu Yang ◽  
Yu-Tsan Lin ◽  
Li-Chieh Wang ◽  
Jyh-Hong Lee ◽  
...  
Keyword(s):  
Clinical Manifestations ◽  
Henoch Schonlein Purpura ◽  
Adults And Children ◽  
Schonlein Purpura ◽  
Henoch Schönlein Purpura

scholarly journals Henoch–Schönlein Purpura (IgA Vasculitis) in Association with Thyrotoxicosis

2021 ◽  
Vol 2021 ◽  
pp. 1-3
Author(s):  
Mojgan Sanjari ◽  
Mohammadreza Shakibi ◽  
Moeinadin Safavi
Keyword(s):  
Clinical Manifestations ◽  
Skin Lesions ◽  
Small Vessel Vasculitis ◽  
Iga Vasculitis ◽  
Henoch Schonlein Purpura ◽  
Cutaneous Lesions ◽  
Radioiodine Ablation ◽  
Antithyroid Agents ◽  
Schonlein Purpura ◽  
Henoch Schönlein Purpura

Graves’ disease is the most common cause of hyperthyroidism, which is characterized by thyroid antibodies and the following clinical manifestations: goiter, ophthalmopathy, and pretibial myxedema. On the other hand, Henoch–Schönlein purpura is an IgA-mediated small-vessel vasculitis. Review of the literature showed a relationship between propylthiouracil overdose and the following Henoch–Schönlein purpura (IgA vasculitis) as a side effect. The patient was a 31-year-old woman with a chief complaint of tremor and significant weight loss who contracted pruritic palpable purpura during her disease course. Then, she underwent the treatment of hyperthyroidism by methimazole which intensified her cutaneous lesions. The diagnosis of Henoch–Schönlein purpura (IgA vasculitis) was confirmed after skin biopsy. Finally, she was treated with colchicine, prednisolone, and radioiodine ablation, which caused her lesions to disappear. The temporal priority of pruritic palpable skin lesions to hyperthyroidism treatment with methimazole suggested that Henoch–Schönlein purpura (IgA vasculitis) was related to hyperthyroidism and was intensified by antithyroid agents in this patient.

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