scholarly journals Cognitive disorders in multiple sclerosis: correlation between neuropsychological, neurophysiological and neuroimaging characteristics

2008 ◽  
Vol 7 (5-1) ◽  
pp. 252-259
Author(s):  
N. F. Musina
Keyword(s):  
Magnetic Resonance Imaging ◽  
Multiple Sclerosis ◽  
Cognitive Functions ◽  
Brain Atrophy ◽  
Mini Mental State Examination ◽  
Cognitive Disorders ◽  
Frontal Assessment Battery ◽  
Resonance Imaging ◽  
State Examination

Multiple sclerosis (MS) — autoimmune disease of CNS, characterized by myelin destruction and axonal damage. To study cognitive functions, the authors used the Mini-Mental State Examination (MMSE), the frontal assessment battery, the procedure developed by A.R. Luriya, neurophysiological characteristics. 71 patients were underwent magnetic resonance imaging. The aim of the study was to analyse the parameters of neuropsychological method, cognitive evoked potentials P300 and the role of brain atrophy in MS. The cognitive functions, the activity of the disease and the expression of brain atrophy are bound by the certain way.

scholarly journals Cognitive disturbances in patients with multiple sclerosis

2008 ◽  
Vol 7 (3) ◽  
pp. 62-67
Author(s):  
V. M. Alifirova ◽  
Yu. Yu. Orlova ◽  
N. F. Musina
Keyword(s):  
Multiple Sclerosis ◽  
Mini Mental State Examination ◽  
Neurological Diseases ◽  
Cognitive Disorders ◽  
Frontal Assessment Battery ◽  
Neurocognitive Functions ◽  
Cognitive Disturbances ◽  
State Examination ◽  
Cognitive Disturbance

Multiple sclerosis (MS) one of the most common neurological diseases. MS — autoimmune disease of CNS, characterized by myelin destruction and axonal damage. The aim of the study was to analyse the role of cognitive disorders in MS. Neurocognitive functions have been studied in 109 patients with MS. To study cognitive functions, the authors used the Mini-Mental State Examination (MMSE), the frontal assessment battery, the procedure developed by A.R. Luriya. It is emphasized that cognitive disturbance may appear on the earlier stages of MS.

Association between Trigeminal Neuralgia and Multiple Sclerosis: Role of Magnetic Resonance Imaging

2021 ◽  
Vol 15 (6) ◽  
pp. 1927-1930
Author(s):  
Tahir Baig ◽  
Adnan Ahmed ◽  
Atif Hussain ◽  
Rabia Shah ◽  
Muhammad Tahir ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Multiple Sclerosis ◽  
Magnetic Resonance ◽  
Trigeminal Neuralgia ◽  
Wilcoxon Test ◽  
P Value ◽  
World Population ◽  
Resonance Imaging ◽  
Affected Side

Background: Trigeminal neuralgia (TN) is a severe neuropathic unilateral facial pain affecting about 30% percent of the world population. Neuropathic pains are considered to be associated with multiple sclerosis (MS).Multiple sclerosis is a chronic inflammatory condition causing demyelination and degeneration of axons in central nervous system. Objective: The objective of the study is to determine role of Magnetic Resonance Imaging to find association between trigeminal neuralgia and multiple sclerosis. Methods: The prospective cohort study was conducted for six months in Radiology Department of Hayatabad Medical Complex, Peshawar from September 2020 to February 2021. Initially 250 patients were screened for multiple sclerosis. The study recruited a total of 35 patients of MS visited neuroradiology department, out of which 26 patients were enrolled in the study. The participants with age of 18 years and onward of both genders with definitive symptoms of TN with MS that is having unilateral TN pain (that is sharp shooting electric pulse like) lasting for up-to 2minutes precipitated with an environmental stimulus were included in the study. The patients (n=6) with bilateral MS with TN and cognitive disturbances (n=3) were excluded from the study. Results: The study recruited a total of 26 participants with MS related TN. The clinical examination didn’t show any difference between the three groups with the p-value less than 0.001. Age at the onset of MS was younger in patients with MS related sensory disturbances compared to other two groups, with p-value less than 0.05. The frequency of the affected side was different in all three groups with the p-value less than 0.05 as tested by Fischer exact test. Trigeminal reflex tests done for different components such as R1 and SP1 showed longer latency periods for the affected side after stimulation and unaffected side after stimulation with the mean of 14.2± 4.4 and 15.3±3.2, 16.3±4.2 and 17.4±5.2ms and p-value less than 0.001 as shown by Wilcoxon test. Conclusion: The study showed significant association between trigeminal neuralgia and multiple sclerosis with the greater efficacy of using MRI as imaging technique to find this association. Keywords: Multiple sclerosis, Magnetic Resonance Imaging, Trigeminal neuralgia

Microglial imaging with positron emission tomography and atrophy measurements with magnetic resonance imaging in multiple sclerosis: a correlative study

2005 ◽  
Vol 11 (2) ◽  
pp. 127-134 ◽  
Author(s):  
J Versijpt ◽  
J C Debruyne ◽  
K J Van Laere ◽  
F De Vos ◽  
J Keppens ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Multiple Sclerosis ◽  
Magnetic Resonance ◽  
Brain Atrophy ◽  
Microglial Activation ◽  
Grey Matter ◽  
Disease Duration ◽  
A Priori ◽  
Resonance Imaging ◽  
Normal Appearing White Matter

Objective: The objectives of the present study were to assess brain atrophy in multiple sclerosis (MS) patients during different disease stages and to investigate by PET and [11C]PK11195, a marker of microglial activation, the relationship between inflammation, atrophy and clinically relevant measures. Methods: Eight healthy subjects and 22 MS patients were included. Semiquantitative [11C]PK11195 uptake values, with normalization on cortical grey matter, were measured for magnetic resonance imaging T2- and T1-lesions and normal appearing white matter (NAWM). As atrophy index we used the ratio of the amount of white and grey matter divided by the ventricular size, using an optimized a priori based segmentation algorithm (SPM99). Results: Atrophy was significantly greater in MS patients compared to age-matched controls. A significant correlation was found between brain atrophy and both disease duration and disability, as measured with the Expanded Disability Status Scale. For NAWM, [11C]PK11195 uptake increased with the amount of atrophy, while T2-lesional [11C]PK11195 uptake values decreased according to increasing brain atrophy. Conclusions: The present study suggests that brain atrophy, correlating with disease duration and disability, is directly related to NAWM and T2-lesional inflammation as measured by microglial activation.

scholarly journals Hábitos de higiene bucal e uso de serviços odontológicos por estudantes do município de Canindé-CE

2020 ◽  
Vol 5 (8) ◽  
pp. 21-28
Author(s):  
Cosmo Helder Ferreira da Silva ◽  
Heloyse Maria Rocha Arruda ◽  
Adrícia Kelly Marques Bento ◽  
Gabriela Soares Santana ◽  
Karlos Eduardo Rodrigues Lima ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Multiple Sclerosis ◽  
Magnetic Resonance ◽  
Resonance Imaging ◽  
Imaging Diagnosis ◽  
Advantages And Disadvantages ◽  
Esclerosis Múltiple ◽  
Advanced Stages ◽  
Multiple Sclerosis Diagnosis

Analisar Este estudo tem o objetivo de apresentar as características, particularidades e aplicações variadas do exame de ressonância magnética no diagnóstico da esclerose múltipla (EM), apresentando suas vantagens e desvantagens no diagnóstico diferencial destas afecções. Está delineado pela proposta de uma pesquisa embasada nos pressupostos da revisão da literatura. Com isso, utilizou para análise estudos que tenham sido publicados em periódicos nacionais e internacionais, indexados em base de dados como BIREME e SCIELO, que tenham como enfoque principal a questão que envolve os critérios para a importância da ressonância magnética como método diagnóstico. Com o resultado da pesquisa foi possível concluir que o papel do diagnóstico por imagem na investigação da EM se mostra de muita importância, visto que apenas com a investigação clínica não é possível ter a certeza desta patologia se mostrando, então, como um importante instrumento auxiliar na detecção dos estágios iniciais e avançados da doença, permitindo a visualização das imagens e dos processos inerentes à patologia em questão.Descritores: Ressonância Magnética, Esclerose Múltipla, Diagnóstico. Diagnosis of multiple sclerosis by magnetic resonance imagingAbstract: This study aims to present the characteristics, particularities and varied applications of magnetic resonance imaging in the diagnosis of multiple sclerosis (MS), presenting its advantages and disadvantages in the differential diagnosis Of these affections. It is delineated by the proposal of a research based on the assumptions of the literature review. Thus, studies that have been published in national and international journals, indexed in databases such as BIREME and SCIELO, have been used to analyze the main focus of the issue that involves the criteria for the importance of magnetic resonance as a diagnostic method. With the result of the research it was possible to conclude that the role of imaging diagnosis in the investigation of EM is very important, since only with clinical research it is not possible to be sure of this pathology showing, then, as an important auxiliary tool to detect the early and advanced stages of the disease, allowing the visualization of the images and processes inherent to the pathology in question.Descriptors: Magnetic Resonance Imaging, Multiple Sclerosis, Diagnosis. Diagnóstico de la esclerosis múltiple por resonancia magnéticaResumen: Este estudio pretende presentar las características, particularidades y variadas aplicaciones de la resonancia magnética en el diagnóstico de la esclerosis múltiple (EM), presentando sus ventajas y desventajas en el diagnóstico diferencial de estos afectos. Está delineado por la propuesta de una investigación basada en los supuestos de la revisión bibliográfica. Así, se han utilizado estudios publicados en revistas nacionales e internacionales, indexados en bases de datos como BIREME y SCIELO, para analizar el enfoque principal del tema que involucra los criterios de la importancia de la resonancia magnética como método de diagnóstico. Con el resultado de la investigación fue posible concluir que el papel del diagnóstico por imágenes en la investigación del EM es muy importante, puesto que solamente con la investigación clínica no es posible estar seguro de esta patología monstrándose, entonces, como una importante herramienta auxiliar para detectar las etapas tempranas y avanzadas de la enfermedad, permitiendo la visualización de las imágenes y procesos inherentes a la patología en cuestión.Descriptores: Imagen de Resonancia Magnética, Esclerosis Múltiple, Diagnóstico.

Cognition and multiple sclerosis: The role of magnetic resonance imaging.

2018 ◽  
pp. 33-65
Author(s):  
Quinten van Geest ◽  
Kim A. Meijer ◽  
Jeroen J. G. Geurts ◽  
Hanneke E. Hulst
Keyword(s):  
Magnetic Resonance Imaging ◽  
Multiple Sclerosis ◽  
Magnetic Resonance ◽  
Resonance Imaging
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