scholarly journals Characterization of cellular immune response associated with infection intensity in chronic opisthorchiasis patients

2010 ◽  
Vol 9 (1) ◽  
pp. 40-44
Author(s):  
Ye. N. Ilyinskikh ◽  
N. N. Ilyinskikh ◽  
I. N. Ilyinskikh ◽  
A. V. Lepyokhin ◽  
A. Yu. Yurkin ◽  
...  
Keyword(s):  
Immune Response ◽  
Peripheral Blood ◽  
Cellular Immune Response ◽  
Infection Intensity ◽  
Cellular Immune

The aim of this work was to assess the lymphocyte transformating responses to stimulation with antigens or mitogens in chronic opisthorchiasis patients with low and high degrees of infection intensity. The heavily infected patients demonstrated the lowest levels of stimulated lymphocyte transformating response in vitro, and CD8+ or CD16+ counts in peripheral blood.

A 55 kDa antigen of Pneumocystis carinii: analysis of the cellular immune response and characterization of the gene

1993 ◽  
Vol 7 (5) ◽  
pp. 745-753 ◽  
Author(s):  
A. G. Smulian ◽  
S. A. Theus ◽  
N. Denko ◽  
P. D. Walzer ◽  
J. R. Stringer
Keyword(s):  
Immune Response ◽  
Cellular Immune Response ◽  
Pneumocystis Carinii ◽  
Cellular Immune

scholarly journals ANTIGEN RECOGNITION: IN VITRO STUDIES ON THE SPECIFICITY OF THE CELLULAR IMMUNE RESPONSE

1969 ◽  
Vol 130 (5) ◽  
pp. 1031-1045 ◽  
Author(s):  
Stuart F. Schlossman ◽  
Judith Herman ◽  
Arieh Yaron
Keyword(s):  
Immune Response ◽  
Lymph Node ◽  
Cellular Immune Response ◽  
Lymph Node Cell ◽  
Antigen Receptors ◽  
Lymph Node Cells ◽  
Cellular Immune ◽  
Conventional Antibody ◽  
Sensitive Population

Studies of the immunochemical specificity of antigen-induced thymidine-2-14C incorporation in lymph node cells obtained from animals immunized to a series of closely related α-DNP-oligolysines, ϵ-DNP-oligolysines, and oligolysines have shown that the sensitized cell exhibits an extraordinary degree of specificity for antigen. The sensitized cell is maximally stimulated by the homologous immunizing antigen and can discriminate among compounds which differ from one another only in the position of a dinitrophenyl group or D-lysine residue on an identical oligolysine backbone. These studies support the view that the immunogen is not degraded prior to the induction of the immune response, and that the majority of cells produced as a consequence of immunization have stereospecific antigen receptors for the DNP-oligolysine used to induce the response; a smaller and more variably sized population of cells is produced with receptors specific for the oligolysine portion of the immunizing antigen. When specifically sensitized lymph node cell cultures are stimulated in vitro by heterologous DNP-oligolysines, the oligolysine- and not the DNP-oligolysine-sensitive population of cells appears to play a crucial role in the specificity of such cross-reactions. It is concluded from these studies that the antigen receptor on the sensitized lymph node cell differs in both kind and degree from conventional antibody. The chemical nature of the receptor and the means by which this receptor reacts with antigen to initiate the biosynthetic or proliferative cellular immune response still remain undefined.

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