scholarly journals Radiation-Induced Erectile Dysfunction in Prostate Cancer Patients: Up-to-Date View on Pathogenesis

2021 ◽  
Vol 102 (1) ◽  
pp. 66-74
Author(s):  
R. V. Novikov ◽  
S. N. Novikov ◽  
V. V. Protoshchak ◽  
I. B. Dzhalilov ◽  
S. S. Litinskiy
Keyword(s):  
Prostate Cancer ◽  
Radiation Therapy ◽  
Erectile Dysfunction ◽  
Literature Review ◽  
Cancer Patients ◽  
Radiation Treatment ◽  
Sexual Disorders ◽  
Number Of Patients ◽  
Radical Therapy ◽  
Radiation Induced

The true causes of sexual disorders after radiation treatment of prostate cancer, among which the central role is occupied by erectile dysfunction, are still not fully clarified. The number of patients who undergo various radiation-exposure options as a radical therapy is steadily increasing, which makes the issue very relevant. This literature review provides up-to-date data on the most studied probable mechanisms of the erectile function status decline after radiation therapy for prostate cancer.

Erectile dysfunction in prostate cancer patients treated with intensity-modulated radiation therapy

2020 ◽  
Vol 57 (1) ◽  
pp. 70
Author(s):  
HalilCumhur Yildirim ◽  
SefikaArzu Ergen ◽  
Emine Sedef ◽  
Merve Sahin ◽  
SongulCavdar Karacam ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Radiation Therapy ◽  
Erectile Dysfunction ◽  
Cancer Patients ◽  
Intensity Modulated Radiation Therapy ◽  
Intensity Modulated

scholarly journals Analysis of the status of radiotherapy care provided to the population of Ukraine. Part 1. Analyzing morbidity and technical supply of radiation therapy in Ukraine

2020 ◽  
Vol 28 (4) ◽  
pp. 337-352
Author(s):  
V. Р. Starenkiy ◽  
O. M. Sukhina ◽  
L. L. Stadnyk ◽  
L. O. Averyanova
Keyword(s):  
Radiation Therapy ◽  
Cancer Patients ◽  
Low Income ◽  
Gamma Ray ◽  
Background Radiation ◽  
Radiation Treatment ◽  
Low Income Countries ◽  
Number Of Patients ◽  
Clinical Consequences ◽  
Low Efficiency

Background. Radiation therapy is an essential in the complex of modern cancer care methods, since it is needed by more than half of cancer patients worldwide. However, each year more than 2 million people from low-income countries are unable to access modern radiotherapy technologies [1]. Thus, the urgent task in the field of radiation oncology is to increase the availability, quality and efficiency of radiotherapy, monitoring the level of technical, methodological and human resourcing of radiation therapy in Ukraine in accordance with trends in Europe and the world. The actual task of the study is to review and analyze the existing level, availability and effectiveness of applying the modern technologies of radiation therapy in the regions of Ukraine. Purpose – analyzing the current state and level of availability of radiotherapy in Ukraine, seeking for opportunities to expand applying it. Materials and methods. Analyzing and comparing statistical data of the National Cancer Registry of Ukraine and the information of IARC GLOBOCAN, IAEA DIRAC Database, summarizing the results. Results. The level of technical and technological equipment as well as staffing of oncology centers of Ukraine has been analyzed, along with assessing quantitative and qualitative components of radiotherapy care in comparison with the average European indicators. The assessment of the state of radiotherapy care in Ukraine was carried out with due regard for the increasing number of patients. Conclusions. According to the WHO, the structure of cancer incidence in Ukraine is similar to the European one, however higher specific mortality rate indicates, first of all, the insufficient level of covering the population of Ukraine by specialized diagnosis and oncological care, its low efficiency and engineering backwardness. It has been determined that radiation therapy in Ukraine is needed annually by at least 90 thousand cancer patients. In fact, only about 44 thousand of them are provided with tele-radiation therapy. First of all, this is due to extremely insufficient radiotherapy equipment available in Ukraine and using outdated radiation treatment technologies in gamma-ray teletherapy that result in its low quality and aggravating the clinical consequences. Given the growing number of cancer patients in 2022, Ukraine will need about 160 machines for tele-radiotherapy. The rise and adjusting the clinical and technical capabilities of regional oncology centers in terms of quality and efficiency of radiation therapy is possible under the conditions of their rapid technical.

Secondary rectal malignancy risk reduction with IMRT and rectal balloon placement during radiation therapy.

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. e15162-e15162
Author(s):  
John Ng ◽  
Ryan J. Burri ◽  
David Paul Horowitz ◽  
Jamie A. Cesaretti ◽  
Johnny Kao ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Radiation Therapy ◽  
Cancer Patients ◽  
Rectal Wall ◽  
Absolute Risk ◽  
Conformal Radiotherapy ◽  
Rectal Balloon ◽  
Dose Volume Histograms ◽  
Radiation Induced ◽  
3D Crt

e15162 Background: The risk of secondary rectal malignancies (SRMs) is a significant concern following radiation therapy for prostate cancer patients. Modern prostate radiotherapy techniques include the use of intensity modulated radiation therapy (IMRT) and rectal balloons to decrease treatment related toxicity. These technologies may also lower the likelihood of radiation-induced SRMs. In this study, a novel biologically-based carcinogenesis model was used to quantify and to compare the predicted risks of SRMs in men treated with or without a rectal balloon in place using either standard 3-D conformal radiotherapy (3D-CRT) or IMRT radiotherapy. Methods: Treatment plans were developed for ten clinically localized prostate cancer patients using CT scans obtained both with and without a rectal balloon in place. Target and normal structures were contoured, and dose-volume histograms (DVHs) for these organs were determined with a planned 3D-CRT dose of 75.6 Gy or with a planned IMRT dose of 81 Gy. A biologically-based mathematical model of spontaneous and radiation-induced carcinogenesis was used to determine the excess absolute risk of SRMs for each plan. These risks were then compared to one another and to the baseline population. Results: Treatment with IMRT and a rectal balloon in place resulted in a significantly lower mean rectal wall dose in all patients compared with treatment with 3D-CRT without a rectal balloon. The average mean rectal wall dose with IMRT and a rectal balloon in place was 31.0 Gy versus 40.1 Gy with 3D-CRT without the rectal balloon (p < 0.001). A significantly higher risk of SRMs was predicted for patients treated with 3-D CRT without rectal balloons when compared with patients treated with IMRT with balloons in place (p < 0.001, relative risk 1.30; 95% confidence interval 1.16-1.44). Conclusions: For prostate cancer patients treated with definitive radiotherapy, the use of IMRT and rectal balloons during radiation, when compared to treatment with 3-D conformal radiotherapy, is associated with a significant reduction in the predicted risk of secondary rectal malignancies.

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