[18F]FMCH PET/CT biomarkers and similarity analysis to refine the definition of oligometastatic prostate cancer

Background The role of image-derived biomarkers in recurrent oligometastatic Prostate Cancer (PCa) is unexplored. This paper aimed to evaluate [18F]FMCH PET/CT radiomic analysis in patients with recurrent PCa after primary radical therapy. Specifically, we tested intra-patient lesions similarity in oligometastatic and plurimetastatic PCa, comparing the two most used definitions of oligometastatic disease. Methods PCa patients eligible for [18F]FMCH PET/CT presenting biochemical failure after first-line curative treatments were invited to participate in this prospective observational trial. PET/CT images of 92 patients were visually and quantitatively analyzed. Each patient was classified as oligometastatic or plurimetastatic according to the total number of detected lesions (up to 3 and up to 5 or > 3 and > 5, respectively). Univariate and intra-patient lesions' similarity analysis were performed. Results [18F]FMCH PET/CT identified 370 lesions, anatomically classified as regional lymph nodes and distant metastases. Thirty-eight and 54 patients were designed oligometastatic and plurimetastatic, respectively, using a 3-lesion threshold. The number of oligometastic scaled up to 60 patients (thus 32 plurimetastatic patients) with a 5-lesion threshold. Similarity analysis showed high lesions' heterogeneity. Grouping patients according to the number of metastases, patients with oligometastatic PCa defined with a 5-lesion threshold presented lesions heterogeneity comparable to plurimetastic patients. Lesions within patients having a limited tumor burden as defined by three lesions were characterized by less heterogeneity. Conclusions We found a comparable heterogeneity between patients with up to five lesions and plurimetastic patients, while patients with up to three lesions were less heterogeneous than plurimetastatic patients, featuring different cells phenotypes in the two groups. Our results supported the use of a 3-lesion threshold to define oligometastatic PCa.

SP7.1.11 Deprivation has No Effect on Oesophagogastric Cancer Outcomes in North of Scotland

Introduction Despite advances in medical therapies and surgical techniques, oesophagogastric cancer survival remains low. Poorer survival and outcomes from colorectal cancer have been reported for patients living in areas of higher socioeconomic deprivation1. Our aim was to determine if deprivation affected oesophagogastric cancer survival in North East of Scotland. Methods A prospective, single-centre observation study was conducted utilising data from oesophago-gastric cancer MDT referrals and outcomes from January 2013 to December 2019. Patient postcodes were cross-referenced with the Scottish Index of Multiple Deprivation (SIMD) 2020 tool which provided a level of deprivation for each address. Survival outcomes were compared across demographic factors, disease factors and stage at presentation across deprivation quintiles. Results 1046 patients were included in this study. There were fewer patients in the most deprived (1st) quintile (n = 65) than in the least deprived (5th) quintile (n = 245). There was no significant difference between oesophageal versus gastric cancer presentations nor was there any difference between T, N or M stage at presentation between the most and least deprived groups. No difference was identified between those commenced on a radical therapy with other treatment plans. No difference in survival time was noted between the groups. Discussion No difference in survival was demonstrated across areas of deprivation within this catchment area. However, Aberdeenshire is an affluent area with less overall deprivation compared with other areas of Scotland.

EFFECTS OF VYAYAM AND NASYA IN THE MANAGEMENT OF HYPOTHYROIDISM: CONCEPTUAL REVIEW

Lifestyle is accountable for the origin of a diseases; it is a very ancient and famous theory in Ayurveda. Nowa- days there has been a profound change in the dietary habits and lifestyle of human being due to modernization. Deleterious eating habits, along with sedentary lifestyle, cause various ailments including metabolic disorders. Thyroid gland is a key part of the human endocrine system and works together with nervous and immune system and it regulates metabolism by producing and secreting hormones into blood. Inadequate production of thyroid hormone is considered as hypothyroidism. Auto immunity plays a key role in the etiology of hypothyroidism. Global incidence of hypothyroidism is rising rapidly, and it is posing a major health challenge in both developing as well as developed world. Hypothyroidisms influence the standard of life of individuals, despite many progress- es the modern management of hypothyroidism remains disappointing. Looking into the pathogenesis and compli- cation of hypothyroidism, it requires a systemic and radical therapy for which ayurveda may provide a ray of hope through panchakarma, there is abnormality of Jatharagni and Dhatwagni, urdhvajatrugata sthan along with ab- normality of Kapha and Vata Dosha as well as Kaphamedo-Avrita Vata. Thus, the line of treatment involves Deepana, Pachana, Srotoshodhana, Nasya, Vyayam and Kapha vata shaman. Keywords: Hypothyroidism, Agnimandya, Metabolism, Nasya, Vyayam.

Radiation-Induced Erectile Dysfunction in Prostate Cancer Patients: Up-to-Date View on Pathogenesis

The true causes of sexual disorders after radiation treatment of prostate cancer, among which the central role is occupied by erectile dysfunction, are still not fully clarified. The number of patients who undergo various radiation-exposure options as a radical therapy is steadily increasing, which makes the issue very relevant. This literature review provides up-to-date data on the most studied probable mechanisms of the erectile function status decline after radiation therapy for prostate cancer.

Near infrared II laser controlled free radical release nanogenerator for synergistic nitric oxide and alkyl radical therapy of breast cancer

Recently, alkyl radical has attracted much attention in cancer therapy due to its oxygen-independent generation property. For the first time, alkyl radical and nitric oxide (NO) combined therapy is demonstrated...

СОПОСТАВЛЕНИЕ РЕАЛЬНЫХ И РАСЧЕТНЫХ ПОСЛЕОПЕРАЦИОННЫХ ПОКАЗАТЕЛЕЙ ФУНКЦИИ ВНЕШНЕГО ДЫХАНИЯ У БОЛЬНЫХ ТУБЕРКУЛЕЗОМ ЛЕГКИХ, ПЕРЕНЕСШИХ ПНЕВМОНЭКТОМИЮ, "Вестник Центрального научно-исследовательского института туберкулеза"

Введение. Туберкулез (ТБ) по-прежнему остается актуальной проблемой и смертельно опасной инфекцией, которой, по данным ВОЗ, в 2019 г. заболело около 10,0 млн человек и от которой умерли 1,4 млн. В настоящее время более эффективному лечению препятствует продолжающийся рост числа случаев ТБ с лекарственной устойчивостью (ЛУ) возбудителя, что увеличивает значение хирургического этапа лечения данного заболевания. В структуре хирургических вмешательств при ТБ легких преобладают резекционные операции. Среди них доля пневмонэктомии (ПЭ) варьирует в достаточно широких пределах: от 0,4 до 11,1%, а в некоторых клиниках может достигать 15,8–20%. По признанию большинства авторов, ПЭ до сих пор остается операцией высокого риска по причине тяжести состояния пациентов, обусловленной множественными сопутствующими заболеваниями и функциональными нарушениями сердечно-легочной системы, развившимися на фоне прогрессирующего течения ТБ легких. В некоторых случаях удаление пораженного легкого остается единственно возможным способом спасения жизни пациента. В связи с этим необходимо тщательно оценивать функциональную операбельность больного. Основным методом диагностики и оценки степени тяжести вентиляционных нарушений является спирометрия. Комплексная оценка функциональной операбельности производится на основании полученных показателей, с использованием формул, рекомендованных Европейским респираторным обществом и Европейским обществом торакальных хирургов, а также Британским торакальным обществом (ERS/ESTS clinical guidelines on fitness for radical therapy in lung cancer patients, 2009, British Thoracic Society and the Society for Cardiothoracic Surgery in Great Britain and Ireland, 2010). Однако данные рекомендации посвящены функциональной операбельности у больных раком легких. Для больных ТБ легких в доступной литературе не удалось найти алгоритмов комплексной оценки функциональной операбельности. Цель исследования: проведение сравнительного анализа реальных и расчетных показателей функции внешнего дыхания у больных ТБ легких с использованием ранее предложенных способов для больных раком легкого.