Thixotropic effect of some biochemical factors in ischaemic stroke

Background. Yield shear stress (YSS) well characterizes the thixotropic status of blood, that exemplifies a reversible loss of blood fluidity due to a low shear rate. At the stable haematocrit ratio YSS depends mainly on the fibrinogen level.Aim. Since the role of other biochemical factors in the YSS phenomenon in cerebral ischaemia has not been well known, we have undertaken this problem in a group of stroke patients. Material and Methods. The study was carried out in 36 patients with acute ischaemic stroke and in 12 controls. YSS was estimated by means of microviscometric method. In all subjects the concentration of the following biochemical factors were assayed: albumin, IgG, IgA, IgM, apolipoprotein A, and B, cholesterol, triglycerides, LDL, HDL and fibrinogen. Then the thixotroipic effect of all biochemical factors and their correlations to fibrinogen were estimated by means of mathematical formulas.Results. We found a positive correlation in relation to the following thixotropic effects: for all subjects and separately for patients’ group: Alb(YSS) (p < 0.001), ApoA(YSS) (p < 0.001), ApoB(YSS) (p < 0.05), chol(YSS) (p < 0.01), HDL(YSS) (p < 0.05); for patients group without additional diseases: Alb(YSS) (p < 0.05), ApoA(YSS) (p < 0.005), chol(YSS) (p < 0.05), HDL(YSS) (p < 0.02), LDL(YSS) (p < 0.05). There were not any significant correlations in controls.Conclusions. Results of the study indicated that in the interaction between the red cells and fibrinogen some additional factors appearing or activating during ischaemic process may play a role.

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Association of serum galectin‐3 with risks of death and vascular events in acute ischaemic stroke patients: the role of hyperglycemia

European Journal of Neurology ◽

10.1111/ene.13856 ◽

2018 ◽

Vol 26 (3) ◽

pp. 415-421

Author(s):

N. Zeng ◽

A. Wang ◽

C. Zhong ◽

X. Zheng ◽

Z. Zhu ◽

...

Keyword(s):

Ischaemic Stroke ◽

Acute Ischaemic Stroke ◽

Stroke Patients ◽

Vascular Events ◽

Galectin 3

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The Influence of Base Oil and Thixotropy on Magnetorheological Property of MRF

Applied Mechanics and Materials ◽

10.4028/www.scientific.net/amm.320.19 ◽

2013 ◽

Vol 320 ◽

pp. 19-24

Author(s):

Jian Jian Yang ◽

Hua Yan ◽

Zhi De Hu ◽

Shi Xiang Xu

Keyword(s):

Shear Stress ◽

Shear Rate ◽

Magnetorheological Fluid ◽

Mineral Oil ◽

Dispersed Phase ◽

Zero Field ◽

Rotational Viscometer ◽

Base Oil ◽

Low Shear

Adopting carbonyl iron powder and silicone/mineral oil as suspend phase and dispersed phase separately,and silica, kaolin as lubricant additives,magnetorheological (MR) fluid was prepared by ball milling. The apparent viscosity of base oil and shear stress were measured on a modified rotational viscometer. The experimental results demonstrated that an appropriate viscosity of base oil contributed to the rheology of MRF. Adding a small amount of thixotropy into MRF had little influence on zero-field viscosity, which facilitated the application of MRF to maintain adequate liquidity. Under low shear rate conditions, the shear stress was improved by adding thixotropy to some extent, especially in the mineral oil-based magnetorheological fluid, in which the role of silica was superior to kaolin.

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DETERMINING STROKE ONSET TIME USING QUANTIATIVE MRI: PRELIMINARY EVIDENCE OF AN ADC/QT2 MISMATCH IN ACUTE ISCHAEMIC STROKE PATIENTS

10.26226/morressier.58e389b1d462b802923850c8 ◽

2017 ◽

Author(s):

Bryony McGarry

Keyword(s):

Ischaemic Stroke ◽

Acute Ischaemic Stroke ◽

Onset Time ◽

Preliminary Evidence ◽

Stroke Onset ◽

Stroke Patients

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A physiological perspective of the associations between hydration status and CTP neuroimaging parameters in hyper‐acute ischaemic stroke patients

Clinical Physiology and Functional Imaging ◽

10.1111/cpf.12690 ◽

2021 ◽

Author(s):

Alex Buoite Stella ◽

Miloš Ajčević ◽

Giovanni Furlanis ◽

Carlo Lugnan ◽

Marina Gaio ◽

...

Keyword(s):

Ischaemic Stroke ◽

Acute Ischaemic Stroke ◽

Hydration Status ◽

Stroke Patients

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Mechanical thrombectomy in acute ischaemic stroke patients with pre-interventional intracranial haemorrhage following intravenous thrombolysis

The Neuroradiology Journal ◽

10.1177/19714009211009112 ◽

2021 ◽

pp. 197140092110091

Author(s):

Hanna Styczen ◽

Matthias Gawlitza ◽

Nuran Abdullayev ◽

Alex Brehm ◽

Carmen Serna-Candel ◽

...

Keyword(s):

Clinical Outcome ◽

Ischaemic Stroke ◽

Acute Ischaemic Stroke ◽

Intracranial Haemorrhage ◽

Mechanical Thrombectomy ◽

Intravenous Thrombolysis ◽

Modified Rankin Scale ◽

Large Vessel Occlusion ◽

Stroke Patients ◽

Vessel Occlusion

Background Data on outcome of endovascular treatment in patients with acute ischaemic stroke due to large vessel occlusion suffering from intravenous thrombolysis-associated intracranial haemorrhage prior to mechanical thrombectomy remain scarce. Addressing this subject, we report our multicentre experience. Methods A retrospective analysis of consecutive acute ischaemic stroke patients treated with mechanical thrombectomy due to large vessel occlusion despite the pre-interventional occurrence of intravenous thrombolysis-associated intracranial haemorrhage was performed at five tertiary care centres between January 2010–September 2020. Baseline demographics, aetiology of stroke and intracranial haemorrhage, angiographic outcome assessed by the Thrombolysis in Cerebral Infarction score and clinical outcome evaluated by the modified Rankin Scale at 90 days were recorded. Results In total, six patients were included in the study. Five individuals demonstrated cerebral intraparenchymal haemorrhage on pre-interventional imaging; in one patient additional subdural haematoma was observed and one patient suffered from isolated subarachnoid haemorrhage. All patients except one were treated by the ‘drip-and-ship’ paradigm. Successful reperfusion was achieved in 4/6 (67%) individuals. In 5/6 (83%) patients, the pre-interventional intracranial haemorrhage had aggravated in post-interventional computed tomography with space-occupying effect. Overall, five patients had died during the hospital stay. The clinical outcome of the survivor was modified Rankin Scale=4 at 90 days follow-up. Conclusion Mechanical thrombectomy in patients with intravenous thrombolysis-associated intracranial haemorrhage is technically feasible. The clinical outcome of this subgroup of stroke patients, however, appears to be devastating with high mortality and only carefully selected patients might benefit from endovascular treatment.

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