scholarly journals Rationale, design and methods planned in a prospective study concerning the circadian rhythm of heart rate asymmetry in healthy subjects

2020 ◽  
Vol 89 (4) ◽  
pp. e492
Author(s):  
Greta Sibrecht ◽  
Tomasz Krauze ◽  
Renata Dobkowska ◽  
Andrzej Wykrętowicz ◽  
Jarosław Piskorski ◽  
...  
Keyword(s):  
Physical Activity ◽  
Heart Rate ◽  
Circadian Rhythm ◽  
Heart Rhythm ◽  
Sleep Apnoea ◽  
Time Of Day ◽  
Rate Asymmetry ◽  
Obstructive Sleep ◽  
Heart Rate Asymmetry ◽  
Physiological Phenomenon

Heart rate asymmetry (HRA) is a physiological phenomenon caused by an unequal (asymmetric) contribution of heart rate decelerations and accelerations to the variability (variance) and microstructure of the heart rhythm of sinus origin. HRA has been studied in healthy people and patients with heart failure, diabetes, obstructive sleep apnoea, ischaemic heart disease, and survivors of myocardial infarction. HRA is a particular form of the heart rate variability (HRV) phenomenon related to the changes in the duration of cardiac cycles of sinus origin. HRV is influenced by physical activity, age, gender or time of day. It has been reported that HRA expression differs between day and night. However, its circadian rhythm has not been analysed so far. Moreover, the differences in HRA expression related to gender, level of physical activity or age have not been investigated either. With this study, we aim to explore the circadian rhythm of the HRA features, as well as the relation of the HRA expression to gender, physical activity, sleep pattern and body composition in a group of at least 100 healthy adults of both sexes aged between 19 and 60. This study might provide reference values for HRA as well as confirming or dismissing the existence of circadian rhythm of this physiological phenomenon.

Obstructive sleep apnea and heart rate asymmetry microstructure during sleep

2013 ◽  
Vol 23 (2) ◽  
pp. 91-100 ◽  
Author(s):  
Przemyslaw Guzik ◽  
Jaroslaw Piskorski ◽  
Kokab Awan ◽  
Tomasz Krauze ◽  
Michael Fitzpatrick ◽  
...  
Keyword(s):  
Heart Rate ◽  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Rate Asymmetry ◽  
Obstructive Sleep ◽  
Heart Rate Asymmetry

Modifying effects of the R389G β1-adrenoceptor polymorphism on resting heart rate and blood pressure in patients with obstructive sleep apnoea

2005 ◽  
Vol 110 (1) ◽  
pp. 117-123 ◽  
Author(s):  
Jan Börgel ◽  
Tino Schulz ◽  
Nina K. Bartels ◽  
Jörg T. Epplen ◽  
Nikolaus Büchner ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Obstructive Sleep Apnoea ◽  
Nervous Activity ◽  
Sleep Apnoea ◽  
Cpap Therapy ◽  
Pressure Therapy ◽  
Obstructive Sleep ◽  
Significant Difference ◽  
The Impact

OSA (obstructive sleep apnoea) stimulates sympathetic nervous activity and elevates resting HR (heart rate) and BP (blood pressure). In the present study in a cohort of 309 untreated OSA patients, the resting HR and BP during the daytime were correlated with AHI (apnoea/hypopnea index) and compared with patients with R389R (n=162), R389G (n=125) and G389G (n=22) genotypes of the β1-adrenoreceptor R389G polymorphism. We analysed the impact of the genotype on the decline of HR and BP in a subgroup of 148 patients (R389R, n=86; R389G, n=54; G389G, n=8) during a 6-month follow-up period under CPAP (continuous positive airway pressure) therapy during which cardiovascular medication remained unchanged. In untreated OSA patients, we found an independent relationship between AHI and resting HR (β=0.096, P<0.001), systolic BP (β=0.09, P=0.021) and diastolic BP (β=0.059, P=0.016). The resting HR/BP, however, did not differ among carriers with the R389R, R389G and G389G genotypes. CPAP therapy significantly reduced HR [−2.5 (−1.1 to −4.0) beats/min; values are mean difference (95% confidence intervals)] and diastolic BP [−3.2 (−1.5 to −5.0) mmHg]. The decline in HR was more significantly pronounced in the R389R group compared with the Gly389 carriers [−4.1 (−2.3 to −5.9) beats/min (P<0.001) compared with −0.2 (2.1 to −2.6) beats/min (P=0.854) respectively; Student's t test between groups, P=0.008]. Diastolic BP was decreased significantly (P<0.001) only in Gly389 carriers (R389G or G389G) compared with R389R carriers [−5.0 (−2.3 to −7.6) mmHg compared with −2.0 (0.4 to −4.3) mmHg respectively]. ANOVA revealed a significant difference (P=0.023) in HR reduction between the three genotypes [−4.1 (±8.4) beats/min for R389R, −0.5 (±9.3) beats/min for R389G and +1.9 (±7.2) beats/min for G389G]. In conclusion, although the R389G polymorphism of the β1-adrenoceptor gene did not influence resting HR or BP in untreated OSA patients, it may modify the beneficial effects of CPAP therapy on these parameters.

Obstructive Sleep Apnoea Impairs Heart Rate Variability in Patients with the Metabolic Syndrome

2007 ◽  
Vol 16 ◽  
pp. S84
Author(s):  
B. Weatherhead ◽  
C. Neil ◽  
M. Barnes ◽  
R. Pierce ◽  
A. Collins ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Heart Rate ◽  
Heart Rate Variability ◽  
Obstructive Sleep Apnoea ◽  
Sleep Apnoea ◽  
The Metabolic Syndrome ◽  
Obstructive Sleep

Heart Rate Asymmetry Analysis Using Poincaré Plot

2013 ◽  
pp. 69-91
Author(s):  
Ahsan Habib Khandoker ◽  
Chandan Karmakar ◽  
Michael Brennan ◽  
Andreas Voss ◽  
Marimuthu Palaniswami
Keyword(s):  
Heart Rate ◽  
Poincaré Plot ◽  
Asymmetry Analysis ◽  
Rate Asymmetry ◽  
Heart Rate Asymmetry

scholarly journals P095 Heart Rate Variability during Sleep in Paroxysmal Atrial Fibrillation patients with and without Obstructive Sleep Apnoea

2021 ◽  
Vol 2 (Supplement_1) ◽  
pp. A52-A52
Author(s):  
A Mohammadieh ◽  
H Dissanayake ◽  
K Sutherland ◽  
S Ucak ◽  
P de Chazal ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Heart Rate ◽  
Heart Rate Variability ◽  
Obstructive Sleep Apnoea ◽  
Paroxysmal Atrial Fibrillation ◽  
Sleep Apnoea ◽  
Relative Reduction ◽  
Obstructive Sleep ◽  
Sympathetic Modulation ◽  
Ectopic Beats

Abstract Introduction Physiological studies have demonstrated the importance of the autonomic nervous system in mediating acute apnoea-induced atrial fibrillation (AF). We aimed to compare Heart Rate Variability (HRV) markers of autonomic function in paroxysmal atrial fibrillation (PAF) patients with and without obstructive sleep apnoea (OSA). A secondary aim was the analysis of ectopic beats in these groups. Methods Nocturnal ECG traces from 89 PAF patients who underwent in-laboratory polysomnography were included. After identifying ectopic beats in the ECGs, periods of arrhythmia as well as sleep apnoea events were excluded. HRV time and frequency domains were reported by sleep stage (REM vs Non-REM) for patients with and without OSA. Results Frequency domain analysis of HRV during non-REM sleep in PAF patients with OSA showed increased cardiac parasympathetic modulation (HF-nu: 39.13 ± 15.74 vs 47.98 ± 14.60, p = 0.008*) and reduced cardiac sympathetic modulation (LF/HF ratio: 2.05 ± 2.02 vs 1.17 ± 0.98, p = 0.007*). Results remained significant after adjusting for age, sex and BMI (adjusted p values 0.024 and 0.018 respectively). PAF patients with severe OSA (AHI ≥ 30/hr) had more AF beats and Ventricular Ectopic Beats than those without severe OSA (22.7 ± 42.8% vs 3.7 ± 17.9%, p = 0.006*, 1.7 ± 3.8 vs 0.3 ± 0.9%, p = 0.004* respectively). Conclusions This is the first study of HRV in AF patients with and without OSA. It suggests a chronic increase in parasympathetic nervous modulation and relative reduction in sympathetic modulation in PAF patients with OSA.

scholarly journals Attention Deficit/Hyperactivity Disorder (ADHD) Is Associated With Altered Heart Rate Asymmetry

2014 ◽  
pp. S509-S519 ◽  
Author(s):  
I. TONHAJZEROVÁ ◽  
I. ONDREJKA ◽  
I. FARSKÝ ◽  
Z. VIŠŇOVCOVÁ ◽  
M. MEŠŤANÍK ◽  
...  
Keyword(s):  
Heart Rate ◽  
Attention Deficit Hyperactivity Disorder ◽  
Attention Deficit ◽  
Physiological Stress ◽  
Regulatory System ◽  
Adverse Outcomes ◽  
Time Asymmetry ◽  
Hyperactivity Disorder ◽  
Rate Asymmetry ◽  
Heart Rate Asymmetry

Attention deficit/hyperactivity disorder (ADHD) is associated with complex neurocardiac integrity. We aimed to study heart rate time asymmetry as a nonlinear qualitative feature of heart rate variability indicating complexity of cardiac autonomic control at rest and in response to physiological stress (orthostasis) in children suffering from ADHD. Twenty boys with ADHD and 20 healthy age-matched boys at the age of 8 to 12 years were examined. The continuous ECG was recorded in a supine position and during postural change from lying to standing (orthostasis). Time irreversibility indices – Porta’s (P%), Guzik’s (G%) and Ehlers’ (E) – were evaluated. Our analysis showed significantly reduced heart rate asymmetry indices at rest (P%: 49.8 % vs. 52.2 %; G%: 50.2 % vs. 53.2 %; p<0.02), and in response to orthostatic load (P%: 52.4 % vs. 54.5 %, G%: 52.3 % vs. 54.5 %; p<0.05) associated with tachycardia in ADHD children compared to controls. Concluding, our study firstly revealed the altered heart rate asymmetry pattern in children suffering from ADHD at rest as well as in response to posture change from lying to standing (orthostasis). These findings might reflect an abnormal complex cardiac regulatory system as a potential mechanism leading to later cardiac adverse outcomes in ADHD.

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