Impact of additional intravenous methylprednisolone pulse therapy on the quality of life in patients with dysthyroid optic neuropathy

Introduction. Dysthyroid optic neuropathy (DON) is a severe complication of Graves’ orbitopathy (GO). Treatment of DON should involve immediate administration of intravenous methylprednisolone (ivMP) in very high doses. It is recommended to include additional 12 pulses of ivMP according to a weekly schedule as a further step of the treatment process. The purpose of this study was to evaluate the influence of a 12-week ivMP treatment on the quality of life (QoL) in DON patients. Material and Methods. A retrospective study was conducted on 6 patients (the tests involved 8 individual eyes) with DON and treated with ivMP in very high doses, followed by orbital decompression in one patient. All patients were qualified for additional treatment with ivMP in a 12-week protocol and completed the Polish version of the GOQoL questionnaire before and after the therapy. Visual acuity (VA) and diplopia were examined prior to the administration of ivMP pulses for DON, as well as before and after the additional ivMP treatment. Results. A minimal clinically important difference in QoL was observed in four patients at the end of the additional ivMP therapy. A significant increase in VA was observed following additional pulses of ivMP compared to the evaluation at the time of the DON diagnosis (p=0.04). Conclusions. Applying additional 12 pulses of ivMP following DON therapy may impact QoL. Performing QoL assessment throughout the entire therapy in patients with DON is particularly important in the clinical practice. Final evaluation of QoL should be performed after completing the entire therapeutic process, which involves surgical treatment to correct diplopia.

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Setting new standards in schizophrenia outcomes: Symptomatic remission 3years before versus after the andreasen criteria

European Psychiatry ◽

10.1016/j.eurpsy.2010.12.011 ◽

2012 ◽

Vol 27 (3) ◽

pp. 170-175 ◽

Cited By ~ 8

Author(s):

P. Gorwood ◽

J. Peuskens ◽

Keyword(s):

Quality Of Life ◽

Functional Outcomes ◽

Additional Treatment ◽

Treatment Goals ◽

The World ◽

Before And After ◽

The Usa ◽

Remission Criteria ◽

Symptomatic Remission

AbstractSymptomatic remission is often mentioned as one of the treatment goals for schizophrenia. However, the consistently with which this is documented in the schizophrenia literature since the introduction of the consensus criteria proposed by Andreasen and colleagues in 2005 has yet to be investigated. Similarly, additional treatment goals which are being discussed include improved functioning and quality of life, but whether these goals are being increasingly documented in the literature alongside symptomatic remission is as yet unknown. The objective of this article is therefore to review the use of the term ‘remission’ in the schizophrenia literature from Europe, USA and the rest of the world from 2002 to 2007, before and after the introduction of the Andreasen criteria. A second objective is to determine whether these manuscripts documenting symptomatic remission are also addressing other concepts such as functioning, quality of life and relationships. This literature review indicates that the use of the Andreasen criteria is indeed increasing, although there are manuscripts documenting alternative remission criteria or using the term remission without documentation of specific remission criteria. From 2004 to 2007 the number of manuscripts mentioning remission without documenting specific criteria has fallen by approximately 50%. Within these manuscripts there is increasing awareness of functioning and quality of life as outcome measures, in particular in manuscripts generated in Europe and the USA. This review highlights the growing importance of co-assessment of symptomatic remission and functional outcomes, and calls for further consideration of the most appropriate and consistent way to evaluate functioning of schizophrenia patients.

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Vision-Related Quality of Life Tends to be More Severely Impaired in Patients with Dysthyroid Optic Neuropathy

Current Eye Research ◽

10.3109/02713683.2013.848901 ◽

2013 ◽

Vol 39 (5) ◽

pp. 532-536 ◽

Cited By ~ 4

Author(s):

Yi Du ◽

Huijing Ye ◽

Kaijun Li ◽

Xin Xiao ◽

Rongxin Chen ◽

...

Keyword(s):

Quality Of Life ◽

Optic Neuropathy ◽

Dysthyroid Optic Neuropathy ◽

Related Quality

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P635: Quality of life and visual impairment in patients with optic neuropathy before and after non-invasive electrical stimulation

Clinical Neurophysiology ◽

10.1016/s1388-2457(14)50730-4 ◽

2014 ◽

Vol 125 ◽

pp. S222

Author(s):

D. Broesel ◽

B.A. Sabel ◽

G.H. Franke ◽

C. Gall

Keyword(s):

Quality Of Life ◽

Electrical Stimulation ◽

Visual Impairment ◽

Optic Neuropathy ◽

Non Invasive ◽

Before And After

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153 Quality of life in typical atrial flutter patients before and after radiofrequency catheter ablation using irrigational and conventional techniques

EP Europace ◽

10.1016/s1099-5129(05)80070-4 ◽

2005 ◽

Vol 7 ◽

pp. 25-25

Keyword(s):

Quality Of Life ◽

Catheter Ablation ◽

Atrial Flutter ◽

Radiofrequency Catheter Ablation ◽

Typical Atrial Flutter ◽

Before And After

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Strategic Role of Zakat in Multidimensional Quality of Life in Sijunjung, Indonesia

The Journal of Muamalat and Islamic Finance Research ◽

10.33102/jmifr.v15i1.101 ◽

2018 ◽

Vol 15 (1) ◽

pp. 55-72

Author(s):

Herlin Hamimi ◽

Abdul Ghafar Ismail ◽

Muhammad Hasbi Zaenal

Keyword(s):

Quality Of Life ◽

Positive Impact ◽

Wealth Distribution ◽

Absolute Poverty ◽

Before And After ◽

The Status ◽

Being There ◽

The Impact

Zakat is one of the five pillars of Islam which has a function of faith, social and economic functions. Muslims who can pay zakat are required to give at least 2.5 per cent of their wealth. The problem of poverty prevalent in disadvantaged regions because of the difficulty of access to information and communication led to a gap that is so high in wealth and resources. The instrument of zakat provides a paradigm in the achievement of equitable wealth distribution and healthy circulation. Zakat potentially offers a better life and improves the quality of human being. There is a human quality improvement not only in economic terms but also in spiritual terms such as improving religiousity. This study aims to examine the role of zakat to alleviate humanitarian issues in disadvantaged regions such as Sijunjung, one of zakat beneficiaries and impoverished areas in Indonesia. The researcher attempted a Cibest method to capture the impact of zakat beneficiaries before and after becoming a member of Zakat Community Development (ZCD) Program in material and spiritual value. The overall analysis shows that zakat has a positive impact on disadvantaged regions development and enhance the quality of life of the community. There is an improvement in the average of mustahik household incomes after becoming a member of ZCD Program. Cibest model demonstrates that material, spiritual, and absolute poverty index decreased by 10, 5, and 6 per cent. Meanwhile, the welfare index is increased by 21 per cent. These findings have significant implications for developing the quality of life in disadvantaged regions in Sijunjung. Therefore, zakat is one of the instruments to change the status of disadvantaged areas to be equivalent to other areas.

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