scholarly journals Determination of the Type of Heart Syndrome in Traditional Chinese Medicine with the Bayesian Network Method

2020 ◽  
Vol 12 (2) ◽  
pp. 32-38
Author(s):  
Asto Buditjahjanto
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Bayesian Networks ◽  
Bayesian Network ◽  
Expert Knowledge ◽  
Prior Probabilities ◽  
Network Method

The determination of a disease syndrome in the TCM is difficult enough to determine because it requires a lot of experience in observing patients' symptoms that appear in disease syndrome and their disease syndrome history. Symptoms that appear in one disease syndrome are varied and can also appear in other disease syndromes. This research limits the determination of the type of syndrome only in the heart organ. The purpose of this study is to determine the type of heart syndrome in TCM by using Bayesian Networks. Bayesian Networks is used because it has the advantage of adapting expert knowledge toward the preferences of symptoms that arise at a type of heart syndrome. The expert's preference is in the weights that act as prior probabilities that are used as the basis for calculations on the Bayesian Networks. The results showed that the Bayesian Networks can be used to determine the type of heart syndrome well. The results of trials on 7 patients yield the same diagnosis between the doctor's diagnosis and the Bayesian Networks calculation

scholarly journals High-Sensitivity Determination of Nutrient Elements in Panax notoginseng by Laser-induced Breakdown Spectroscopy and Chemometric Methods

Molecules ◽  
2019 ◽  
Vol 24 (8) ◽  
pp. 1525 ◽  
Author(s):  
Tingting Shen ◽  
Weijiao Li ◽  
Xi Zhang ◽  
Wenwen Kong ◽  
Fei Liu ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Least Squares ◽  
Panax Notoginseng ◽  
High Accuracy ◽  
Laser Induced Breakdown Spectroscopy ◽  
Quantitative Detection ◽  
Breakdown Spectroscopy ◽  
Laser Induced Breakdown

High-accuracy and fast detection of nutritive elements in traditional Chinese medicine Panax notoginseng (PN) is beneficial for providing useful assessment of the healthy alimentation and pharmaceutical value of PN herbs. Laser-induced breakdown spectroscopy (LIBS) was applied for high-accuracy and fast quantitative detection of six nutritive elements in PN samples from eight producing areas. More than 20,000 LIBS spectral variables were obtained to show elemental differences in PN samples. Univariate and multivariate calibrations were used to analyze the quantitative relationship between spectral variables and elements. Multivariate calibration based on full spectra and selected variables by the least absolute shrinkage and selection operator (Lasso) weights was used to compare the prediction ability of the partial least-squares regression (PLS), least-squares support vector machines (LS-SVM), and Lasso models. More than 90 emission lines for elements in PN were found and located. Univariate analysis was negatively interfered by matrix effects. For potassium, calcium, magnesium, zinc, and boron, LS-SVM models based on the selected variables obtained the best prediction performance with Rp values of 0.9546, 0.9176, 0.9412, 0.9665, and 0.9569 and root mean squared error of prediction (RMSEP) of 0.7704 mg/g, 0.0712 mg/g, 0.1000 mg/g, 0.0012 mg/g, and 0.0008 mg/g, respectively. For iron, the Lasso model based on full spectra obtained the best result with an Rp value of 0.9348 and RMSEP of 0.0726 mg/g. The results indicated that the LIBS technique coupled with proper multivariate chemometrics could be an accurate and fast method in the determination of PN nutritive elements for traditional Chinese medicine management and pharmaceutical analysis.

scholarly journals A Modified QuEChERS Method for Determination of Pyrethroid Residues in Traditional Chinese Medicine Oral Liquids by High-Performance Liquid Chromatography

Molecules ◽  
2019 ◽  
Vol 24 (8) ◽  
pp. 1470 ◽  
Author(s):  
Hou ◽  
Chen ◽  
Li ◽  
Liao ◽  
Tsunoda ◽  
...  
Keyword(s):  
High Performance Liquid Chromatography ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
High Performance ◽  
Quechers Method ◽  
Modified Quechers ◽  
Pyrethroid Pesticides ◽  
Oral Liquid ◽  
The Matrix

Pyrethroid residues in traditional Chinese medicines have been a serious threat to the health and treatment of patients. However, because of the matrix complexity of traditional Chinese medicine, the detection of pyrethroid residues remains a challenge. Therefore, we developed a QuEChERS method coupled with high-performance liquid chromatography and ultraviolet detection (HPLC-UV) for the determination of pyrethroid pesticides in three kinds of traditional Chinese medicine oral liquid preparations, and we investigated and optimized the extraction conditions. The matrix effect was estimated in the organic solvent and the actual samples by comparing the slopes of calibration curves, and the results showed that the matrix effect is not significant when using the modified QuEChERS method. The pyrethroid pesticides could be completely separated in 30 min. The linear correlation coefficients were more than 0.999, and the recoveries of all the pyrethroid pesticides ranged from 87.2% to 104.8%. The intra-day precisions (n = 5) were 2.44–4.62%, and the inter-day precisions (n = 5) were 1.06–3.02%. Moreover, the limits of detection were in the range of 0.007–0.018 ng mL-1, while the limits of quantitation were in the range of 0.022–0.057 ng mL-1. This simple, low-cost, and highly sensitive analytical method can be a potential tool for the analysis of pyrethroid residues in traditional Chinese medicine oral liquid preparations.

Simple one-step preconcentration and cleanup with a micellar system for high performance liquid chromatography determination of pyrethroids in traditional Chinese medicine

2015 ◽  
Vol 7 (5) ◽  
pp. 1691-1700 ◽  
Author(s):  
Ligang Chen ◽  
Wenjuan Xing
Keyword(s):  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
High Performance ◽  
Micellar System ◽  
One Step

One-step preconcentration and cleanup using a micellar system for the extraction and preconcentration of four pyrethroids including beta-cyfluthrin, cyhalothrin, cyphenothrin and permethrin in traditional Chinese medicine with the use of Triton™ X-114.

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