Molecular Aspect of Carbapenmase Producing Enterobactericaie

2021 ◽  
Author(s):  
Zenawork Sahle
Keyword(s):  
Molecular Aspect

scholarly journals MOLECULAR ASPECT CORRELATION BETWEEN GLYCATED HEMOGLOBIN (HBA1C), PROTHROMBIN TIME (PT) AND ACTIVATED PARTIAL THROMBOPLASTIN TIME (APTT) ON TYPE 2 DIABETES MELLITUS (T2DM) (Aspek molekuler Hubungan Kadar Hemoglobin Terglikasi (HbA1c), Prothrombin Time (PT) dan Activated Partial Thromboplastin Time (APTT) di Diabetes Melitus Tipe 2)

2018 ◽  
Vol 23 (1) ◽  
pp. 1
Author(s):  
Indranila KS
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Prothrombin Time ◽  
Partial Thromboplastin Time ◽  
Glycated Hemoglobin ◽  
Activated Partial Thromboplastin Time ◽  
Molecular Aspect ◽  
Diabetes Melitus

Diabetes Melitus (DM) memerlukan pengendalian glikemia yang dapat diketahui dengan melakukan pemeriksaan hemoglobinterglikasi (HbA1c). Semakin tinggi kadar hemoglobin terglikasi (HbA1c), semakin tidak terkendali kadar gula darah pasien DM tipe2. Hal ini dapat menyebabkan terjadinya proses hiperkoagulasi dan gangguan mikrovaskular maupun makrovaskular. PemeriksaanProtrombin Time (PT) dan Activated Partial Thromboplastin Time (APTT) diharapkan dapat mendeteksi secara dini adanya gangguankoagulasi di pasien DM tipe 2. Penelitian potong lintang terhadap 72 orang pasien DM tipe 2 yang berusia diatas 18 tahun diperiksakadar HbA1c dan dikaji koagulasi (PT dan APTT). Pasien dengan penyakit penyerta seperti anemia dan kelainan hemoglobin, keganasanatau kelainan hematologis, pasca bedah, hipertiroid, perempuan hamil, riwayat penyakit hati dan pasien yang mengkonsumsi obatobatanyang mengganggu fungsi koagulasi dikeluarkan dari penelitian ini. Uji normalitas data menggunakan Kolmogorov-Smirnovdan analisis hubungan menggunakan uji Pearson. Analisis kenasaban terdapat hubungan antara kadar hemoglobin terglikasi denganProthrombin Time negatif lemah (r= -0,179; p=0,132) dan dengan Activated Partial Thromboplastin Time positif sangat lemah (r=0,016;p=0,892). Berdasarkan telitian ini terdapat hubungan negatif lemah yang bermakna antara kadar hemoglobin terglikasi dengan PTdan hubungan positif sangat lemah yang tidak bermakna dengan Activated Partial Thomboplastin Time.

Molecular aspect of HIV-1 resistance to zidovudine and its reversal

1994 ◽  
Vol 15 (5) ◽  
pp. 137-138
Author(s):  
R. Camsonne ◽  
M-C. Bigot ◽  
P. Bjstany ◽  
D. Pottier ◽  
M. Vergnaud
Keyword(s):  
Molecular Aspect ◽  
Hiv 1

A new molecular aspect in 6-methyl-2-ethyl-3-oxypyridine (6M2E30P) membrane-associated geroprotective action

1987 ◽  
Vol 31 (2) ◽  
pp. 125-127 ◽  
Author(s):  
L.D. Smirnov ◽  
V.P. Zherdev ◽  
D.A. Kuznetsov
Keyword(s):  
Molecular Aspect

scholarly journals Reactive Oxygen Spices Scavenging Behavior of Selenium Upon Vinyl Chloride Interaction With Hemoglobin

2021 ◽  
Author(s):  
Negar Hajimohammadi Oushani ◽  
Masoumeh Valipour ◽  
Parvaneh Maghami
Keyword(s):  
Vinyl Chloride ◽  
Oxygen Transfer ◽  
Vital Role ◽  
The Body ◽  
Ros Production ◽  
Molecular Aspect ◽  
Pleasant Odor ◽  
Uv Visible ◽  
Chloride Interaction ◽  
Vital Factor

Abstract BackgroundVinyl chloride (VC) a colorless gas with a pleasant odor that is capable of entering the body through oral or inhalation routes. Extensive studies on this compound indicated that it is a carcinogen, and Vinyl chloride exposure can result in a specific type of cancer in VC workers. Whereas hemoglobin plays a vital role in oxygen transfer throughout the body, the effect of VC on human hemoglobin has not been studied in a molecular aspect. Furthermore, selenium as an antioxidant is a vital factor for the health of humans and animals. Therefore, the effect of the antioxidant capability of selenium on the interaction between vinyl chloride and hemoglobin was studied.MethodsThe effect of the antioxidant capability of selenium on the interaction between VC and hemoglobin was investigated by different spectroscopy methods such as UV-visible, Fourier-transform infrared, chemiluminescence, and fluorescence spectroscopies and molecular dockingResultsThe results indicated the destruction of hemoglobin structure in the presence of different concentrations of vinyl chloride, but in the presence of selenium, the damaging effect of VC on hemoglobin structure was decreased, relying on its antioxidant capability results.ConclusionsAccording to our findings, vinyl chloride destroyed hemoglobin structure utilizing ROS production, and the presence of selenium as an antioxidant inhibits the destroying effect of vinyl chloride on hemoglobin

scholarly journals The Chromosomal & Molecular Aspect of Mental Retardation: A Review

2014 ◽  
Vol 04 (02) ◽  
pp. 123-127
Author(s):  
Kumari R ◽  
Tiwari M ◽  
Agrawal A ◽  
Upadhyaya O.P.
Keyword(s):  
Mental Retardation ◽  
Molecular Aspect

scholarly journals Molecular Aspect of Good Eating Quality Formation in Japonica Rice

PLoS ONE ◽  
2011 ◽  
Vol 6 (4) ◽  
pp. e18385 ◽  
Author(s):  
Ming-Mao Sun ◽  
Sailila E. Abdula ◽  
Hye-Jung Lee ◽  
Young-Chan Cho ◽  
Long-Zhi Han ◽  
...  
Keyword(s):  
Eating Quality ◽  
Japonica Rice ◽  
Molecular Aspect ◽  
Quality Formation

Carcinosarcoma of the Tongue With Cyclin D1 Gene Amplification

2001 ◽  
Vol 125 (3) ◽  
pp. 433-436
Author(s):  
Hiroaki Suzuki ◽  
Katsushige Yamashiro ◽  
Chikako Yoshida ◽  
Yasunori Fujioka
Keyword(s):  
Cell Cycle ◽  
Squamous Cell Carcinoma ◽  
Cyclin D1 ◽  
Spindle Cell ◽  
D1 Protein ◽  
Molecular Aspect ◽  
Sarcomatous Component ◽  
Cyclin D1 Protein ◽  
Rare Malignancy

Abstract Carcinosarcoma of the tongue is a rare malignancy and its molecular aspect is unclear. A case of carcinosarcoma of the tongue in a 51-year-old man is presented. A polypoid tumor of the tongue, measuring 12 × 12 × 6 mm, was resected. Histologically, the tumor was composed of a squamous cell carcinoma and a spindle cell sarcomatous component. We previously showed that one cell-cycle regulator, the cyclin D1 gene, was frequently amplified in esophageal carcinosarcoma, which shows the same morphologic features as carcinosarcoma of the tongue. In this case, we examined whether the cyclin D1 gene is amplified in carcinosarcoma of the tongue as well. Fluorescence in situ hybridization analysis revealed that the cyclin D1 gene was amplified in both components of carcinosarcoma of the tongue. The cyclin D1 protein was also detected by immunostaining in both components. Our results suggest that the amplification of cyclin D1 gene plays a role in the molecular pathogenesis of carcinosarcoma of the tongue, at least in some cases.

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