scholarly journals Identification of Key Proteins Involved in Axon Guidance Related Disorders: A Systems Biology Approach

2018 ◽  
Author(s):  
Ishtiaque Ahammad
Keyword(s):  
Systems Biology ◽  
Axon Guidance ◽  
Molecular Mechanisms ◽  
Regulatory Mechanisms ◽  
Ppi Network ◽  
Retraction Syndrome ◽  
Horizontal Gaze ◽  
Duane Retraction Syndrome ◽  
Type 3 ◽  
Congenital Fibrosis

Axon guidance is a crucial process for growth of the central and peripheral nervous systems. In this study, 3 axon guidance related disorders, namely- Duane Retraction Syndrome (DRS) , Horizontal Gaze Palsy with Progressive Scoliosis (HGPPS) and Congenital fibrosis of the extraocular muscles type 3 (CFEOM3) were studied using various Systems Biology tools to identify the genes and proteins involved with them to get a better idea about the underlying molecular mechanisms including the regulatory mechanisms. Based on the analyses carried out, 7 significant modules have been identified from the PPI network. Five pathways/processes have been found to be significantly associated with DRS, HGPPS and CFEOM3 associated genes. From the PPI network, 3 have been identified as hub proteins- DRD2, UBC and CUL3.

scholarly journals Identification of Key Proteins Involved in Axon Guidance Related Disorders: A Systems Biology Approach

2018 ◽  
Author(s):  
Ishtiaque Ahammad
Keyword(s):  
Systems Biology ◽  
Axon Guidance ◽  
Molecular Mechanisms ◽  
Regulatory Mechanisms ◽  
Ppi Network ◽  
Retraction Syndrome ◽  
Horizontal Gaze ◽  
Duane Retraction Syndrome ◽  
Type 3 ◽  
Congenital Fibrosis

<p>Axon guidance is a crucial process for growth of the central and peripheral nervous systems. In this study, 3 axon guidance related disorders, namely- Duane Retraction Syndrome (DRS) , Horizontal Gaze Palsy with Progressive Scoliosis (HGPPS) and Congenital fibrosis of the extraocular muscles type 3 (CFEOM3) were studied using various Systems Biology tools to identify the genes and proteins involved with them to get a better idea about the underlying molecular mechanisms including the regulatory mechanisms. Based on the analyses carried out, 7 significant modules have been identified from the PPI network. Five pathways/processes have been found to be significantly associated with DRS, HGPPS and CFEOM3 associated genes. From the PPI network, 3 have been identified as hub proteins- DRD2, UBC and CUL3. </p>

scholarly journals Identification of Key Proteins Involved in Axon Guidance Related Disorders: A Systems Biology Approach

2018 ◽  
Author(s):  
Ishtiaque Ahammad
Keyword(s):  
Systems Biology ◽  
Axon Guidance ◽  
Molecular Mechanisms ◽  
Regulatory Mechanisms ◽  
Ppi Network ◽  
Retraction Syndrome ◽  
Horizontal Gaze ◽  
Duane Retraction Syndrome ◽  
Type 3 ◽  
Congenital Fibrosis

<p>Axon guidance is a crucial process for growth of the central and peripheral nervous systems. In this study, 3 axon guidance related disorders, namely- Duane Retraction Syndrome (DRS) , Horizontal Gaze Palsy with Progressive Scoliosis (HGPPS) and Congenital fibrosis of the extraocular muscles type 3 (CFEOM3) were studied using various Systems Biology tools to identify the genes and proteins involved with them to get a better idea about the underlying molecular mechanisms including the regulatory mechanisms. Based on the analyses carried out, 7 significant modules have been identified from the PPI network. Five pathways/processes have been found to be significantly associated with DRS, HGPPS and CFEOM3 associated genes. From the PPI network, 3 have been identified as hub proteins- DRD2, UBC and CUL3. </p>

scholarly journals Identification of Key Proteins Involved in Axon Guidance Related Disorders: A Systems Biology Approach

2018 ◽  
Author(s):  
Ishtiaque Ahammad
Keyword(s):  
Systems Biology ◽  
Axon Guidance ◽  
Molecular Mechanisms ◽  
Regulatory Mechanisms ◽  
Ppi Network ◽  
Retraction Syndrome ◽  
Horizontal Gaze ◽  
Duane Retraction Syndrome ◽  
Type 3 ◽  
Congenital Fibrosis

<p>Axon guidance is a crucial process for growth of the central and peripheral nervous systems. In this study, 3 axon guidance related disorders, namely- Duane Retraction Syndrome (DRS) , Horizontal Gaze Palsy with Progressive Scoliosis (HGPPS) and Congenital fibrosis of the extraocular muscles type 3 (CFEOM3) were studied using various Systems Biology tools to identify the genes and proteins involved with them to get a better idea about the underlying molecular mechanisms including the regulatory mechanisms. Based on the analyses carried out, 7 significant modules have been identified from the PPI network. Five pathways/processes have been found to be significantly associated with DRS, HGPPS and CFEOM3 associated genes. From the PPI network, 3 have been identified as hub proteins- DRD2, UBC and CUL3. </p>

scholarly journals Identification of Key Proteins Involved in Axon Guidance Related Disorders: A Systems Biology Approach

2018 ◽  
Author(s):  
Ishtiaque Ahammad
Keyword(s):  
Systems Biology ◽  
Axon Guidance ◽  
Molecular Mechanisms ◽  
Regulatory Mechanisms ◽  
Ppi Network ◽  
Retraction Syndrome ◽  
Horizontal Gaze ◽  
Duane Retraction Syndrome ◽  
Type 3 ◽  
Congenital Fibrosis

Axon guidance is a crucial process for growth of the central and peripheral nervous systems. In this study, 3 axon guidance related disorders, namely- Duane Retraction Syndrome (DRS) , Horizontal Gaze Palsy with Progressive Scoliosis (HGPPS) and Congenital fibrosis of the extraocular muscles type 3 (CFEOM3) were studied using various Systems Biology tools to identify the genes and proteins involved with them to get a better idea about the underlying molecular mechanisms including the regulatory mechanisms. Based on the analyses carried out, 7 significant modules have been identified from the PPI network. Five pathways/processes have been found to be significantly associated with DRS, HGPPS and CFEOM3 associated genes. From the PPI network, 3 have been identified as hub proteins- DRD2, UBC and CUL3.

scholarly journals Identification of Key Proteins Involved in Axon Guidance Related Disorders: A Systems Biology Approach

2018 ◽  
Author(s):  
Ishtiaque Ahammad
Keyword(s):  
Systems Biology ◽  
Axon Guidance ◽  
Molecular Mechanisms ◽  
Regulatory Mechanisms ◽  
Ppi Network ◽  
Retraction Syndrome ◽  
Horizontal Gaze ◽  
Duane Retraction Syndrome ◽  
Type 3 ◽  
Congenital Fibrosis

AbstractAxon guidance is a crucial process for growth of the central and peripheral nervous systems. In this study, 3 axon guidance related disorders, namely-Duane Retraction Syndrome (DRS), Horizontal Gaze Palsy with Progressive Scoliosis (HGPPS) and Congenital fibrosis of the extraocular muscles type 3 (CFEOM3) were studied using various Systems Biology tools to identify the genes and proteins involved with them to get a better idea about the underlying molecular mechanisms including the regulatory mechanisms. Based on the analyses carried out, 7 significant modules have been identified from the PPI network. Five pathways/processes have been found to be significantly associated with DRS, HGPPS and CFEOM3 associated genes. From the PPI network, 3 have been identified as hub proteins-DRD2, UBC and CUL3.

scholarly journals Protein-Protein Interaction Network Analysis and Identification of Key Players in nor-NOHA and NOHA Mediated Pathways for Treatment of Cancer through Arginase Inhibition: Insights from Systems Biology

2018 ◽  
Author(s):  
Ishtiaque Ahammad
Keyword(s):  
Systems Biology ◽  
Cancer Progression ◽  
Molecular Mechanisms ◽  
Interaction Network ◽  
Cancer Cell Proliferation ◽  
Biological Processes ◽  
Ppi Network ◽  
Protein Protein Interaction ◽  
Key Players ◽  
Protein Protein Interaction Network

<p>L-arginine is involved in a number of biological processes in our bodies. Metabolism of L-arginine by the enzyme arginase has been found to be associated with cancer cell proliferation. Arginase inhibition has been proposed as a potential therapeutic means to inhibit this process. N-hydroxy-nor-L-Arg (nor-NOHA) and N (omega)-hydroxy-L-arginine (NOHA) has shown promise in inhibiting cancer progression through arginase inhibition. In this study, nor-NOHA and NOHA-associated genes and proteins were analyzed with several Bioinformatics and Systems Biology tools to identify the associated pathways and the key players involved so that a more comprehensive view of the molecular mechanisms including the regulatory mechanisms can be achieved and more potential targets for treatment of cancer can be discovered. Based on the analyses carried out, 3 significant modules have been identified from the PPI network. Five pathways/processes have been found to be significantly associated with nor-NOHA and NOHA associated genes. Out of the 1996 proteins in the PPI network, 4 have been identified as hub proteins- SOD, SOD1, AMD1, and NOS2. These 4 proteins have been implicated in cancer by other studies. Thus, this study provided further validation into the claim of these 4 proteins being potential targets for cancer treatment.</p>

scholarly journals Contralateral lateral rectus muscle recession in patients with Duane retraction syndrome type 3

Eye ◽  
2013 ◽  
Vol 28 (3) ◽  
pp. 279-284 ◽  
Author(s):  
M Snir ◽  
A Dotan ◽  
R Friling ◽  
Y Ron-Kella ◽  
N Goldenberg-Cohen ◽  
...  
Keyword(s):  
Rectus Muscle ◽  
Lateral Rectus ◽  
Syndrome Type ◽  
Lateral Rectus Muscle ◽  
Retraction Syndrome ◽  
Duane Retraction Syndrome ◽  
Type 3

scholarly journals 8q12 microduplication including CHD7: clinical report on a new patient with Duane retraction syndrome type 3

2013 ◽  
Vol 6 (1) ◽  
pp. 49 ◽  
Author(s):  
Anna Baroncini ◽  
Sara Bertuzzo ◽  
Rita Quarantini ◽  
Paolo Ricciardelli ◽  
Roberto Giorda ◽  
...  
Keyword(s):  
Clinical Report ◽  
Syndrome Type ◽  
Retraction Syndrome ◽  
Duane Retraction Syndrome ◽  
Type 3

scholarly journals Chloroquine use in the Treatment of COVID-19: Systems Biology Report of Common Targets of SARS-CoV-2 and Chloroquine.

2020 ◽  
Author(s):  
Serhiy Souchelnytskyi ◽  
Nazariy Souchelnytskyi
Keyword(s):  
Systems Biology ◽  
Adverse Effects ◽  
Molecular Mechanisms ◽  
Regulatory Mechanisms ◽  
First Line ◽  
Cardiac Effects ◽  
Systemic Analysis ◽  
Heart Arrhythmia ◽  
Companion Diagnostic ◽  
Insight Into

Abstract BACKGROUND: Chloroquine use for treatment of COVID-19 patients has been under discussion and recommendations have been shifting from positive to caution or non-conclusive. Variability of clinical outputs requires understanding of mechanisms of the differences. Implementation of a companion diagnostic would allow selecting patients who may benefit from the drug. The first line would be markers already used in clinics. Systems biology opens for an opportunity to identify targets common for chloroquine and SARS-CoV-2. These common targets would be candidates for the companion diagnostic.METHODS: Systemic analysis of molecular mechanisms and markers engaged by chloroquine and SARS-CoV-2 virus was performed. The networks of regulatory mechanisms were explored for an intersection and relevance to clinical markers.RESULTS: Reported here systemic analysis describes the intersection of molecular mechanisms of chloroquine and processes engaged by COVID-19. 266 nodes provide insight into the mechanisms of chloroquine impact on the infection and represent a pool of companion diagnostic markers. As an example, an intersection with the markers of heart arrhythmia retrieved 19 nodes. Thirteen of them were reported in human plasma: levels of albumin, amyloid precursor protein, and endoglin correlate with adverse cardiac effects. CONCLUSIONS: Reported intersection nodes of SARS-CoV-2 and chloroquine are the candidate markers for companion diagnostic of the chloroquine application. Some of these markers are already used in the clinic and their interpretation may contribute to monitoring for adverse effects of chloroquine.

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