scholarly journals A Flexible Genome-Scale Resource of SARS-CoV-2 Coding Sequence Clones

2020 ◽  
Author(s):  
Dae-Kyum Kim ◽  
Jennifer J. Knapp ◽  
Da Kuang ◽  
Patricia Cassonnet ◽  
Payman Samavarchi-Tehrani ◽  
...  
Keyword(s):  
Antiviral Agents ◽  
Health Crisis ◽  
Major Health ◽  
Coding Sequences ◽  
Global Pandemic ◽  
The World ◽  
Flexible Genome ◽  
Widespread Availability ◽  
Genome Scale ◽  
Rapid Transfer

The world is facing a major health crisis, the global pandemic of COVID-19 caused by the SARS-CoV-2 coronavirus, for which no approved antiviral agents or vaccines are currently available. Here we describe a collection of codon-optimized coding sequences for SARS-CoV-2 cloned into Gateway-compatible entry vectors, which enable rapid transfer into a variety of expression and tagging vectors. The collection is freely available via Addgene. We hope that widespread availability of this SARS-CoV-2 resource will enable many subsequent molecular studies to better understand the viral life cycle and how to block it.

scholarly journals A Flexible Genome-Scale SARS-CoV-2 Clone Resource

2020 ◽  
Author(s):  
Dae-Kyum Kim ◽  
Jennifer J. Knapp ◽  
Da Kuang ◽  
Aditya Chawla ◽  
Patricia Cassonnet ◽  
...  
Keyword(s):  
Antiviral Agents ◽  
Health Crisis ◽  
Major Health ◽  
Coding Sequences ◽  
Global Pandemic ◽  
The World ◽  
Flexible Genome ◽  
Widespread Availability ◽  
Genome Scale ◽  
Rapid Transfer

The world is facing a major health crisis, the global pandemic of COVID-19 caused by the SARS-CoV-2 coronavirus, for which no approved antiviral agents or vaccines are currently available. Here we describe a collection of codon-optimized coding sequences for SARS-CoV-2 cloned into Gateway-compatible entry vectors, which enable rapid transfer into a variety of expression and tagging vectors. The collection is freely available via Addgene. We hope that widespread availability of this SARS-CoV-2 resource will enable many subsequent molecular studies to better understand the viral life cycle and how to block it.

scholarly journals A Flexible Genome-Scale Resource of SARS-CoV-2 Coding Sequence Clones

2020 ◽  
Author(s):  
Dae-Kyum Kim ◽  
Jennifer J. Knapp ◽  
Da Kuang ◽  
Patricia Cassonnet ◽  
Payman Samavarchi-Tehrani ◽  
...  
Keyword(s):  
Antiviral Agents ◽  
Health Crisis ◽  
Major Health ◽  
Coding Sequences ◽  
Global Pandemic ◽  
The World ◽  
Flexible Genome ◽  
Widespread Availability ◽  
Genome Scale ◽  
Rapid Transfer

The world is facing a major health crisis, the global pandemic of COVID-19 caused by the SARS-CoV-2 coronavirus, for which no approved antiviral agents or vaccines are currently available. Here we describe a collection of codon-optimized coding sequences for SARS-CoV-2 cloned into Gateway-compatible entry vectors, which enable rapid transfer into a variety of expression and tagging vectors. The collection is freely available via Addgene. We hope that widespread availability of this SARS-CoV-2 resource will enable many subsequent molecular studies to better understand the viral life cycle and how to block it.

scholarly journals A Flexible Genome-Scale SARS-CoV-2 Clone Resource

2020 ◽  
Author(s):  
Dae-Kyum Kim ◽  
Jennifer J. Knapp ◽  
Da Kuang ◽  
Aditya Chawla ◽  
Patricia Cassonnet ◽  
...  
Keyword(s):  
Antiviral Agents ◽  
Health Crisis ◽  
Major Health ◽  
Coding Sequences ◽  
Global Pandemic ◽  
The World ◽  
Flexible Genome ◽  
Widespread Availability ◽  
Genome Scale ◽  
Rapid Transfer

The world is facing a major health crisis, the global pandemic of COVID-19 caused by the SARS-CoV-2 coronavirus, for which no approved antiviral agents or vaccines are currently available. Here we describe a collection of codon-optimized coding sequences for SARS-CoV-2 cloned into Gateway-compatible entry vectors, which enable rapid transfer into a variety of expression and tagging vectors. The collection is freely available via Addgene. We hope that widespread availability of this SARS-CoV-2 resource will enable many subsequent molecular studies to better understand the viral life cycle and how to block it.

scholarly journals A Flexible Genome-Scale SARS-CoV-2 Clone Resource

2020 ◽  
Author(s):  
Dae-Kyum Kim ◽  
Jennifer J. Knapp ◽  
Da Kuang ◽  
Aditya Chawla ◽  
Patricia Cassonnet ◽  
...  
Keyword(s):  
Antiviral Agents ◽  
Health Crisis ◽  
Major Health ◽  
Coding Sequences ◽  
Global Pandemic ◽  
The World ◽  
Flexible Genome ◽  
Widespread Availability ◽  
Genome Scale ◽  
Rapid Transfer

The world is facing a major health crisis, the global pandemic of COVID-19 caused by the SARS-CoV-2 coronavirus, for which no approved antiviral agents or vaccines are currently available. Here we describe a collection of codon-optimized coding sequences for SARS-CoV-2 cloned into Gateway-compatible entry vectors, which enable rapid transfer into a variety of expression and tagging vectors. The collection is freely available via Addgene. We hope that widespread availability of this SARS-CoV-2 resource will enable many subsequent molecular studies to better understand the viral life cycle and how to block it.

scholarly journals A Comprehensive, Flexible Collection of SARS-CoV-2 Coding Regions

2020 ◽  
Vol 10 (9) ◽  
pp. 3399-3402 ◽  
Author(s):  
Dae-Kyum Kim ◽  
Jennifer J Knapp ◽  
Da Kuang ◽  
Aditya Chawla ◽  
Patricia Cassonnet ◽  
...  
Keyword(s):  
Life Cycle ◽  
Viral Life Cycle ◽  
Coding Sequences ◽  
Coding Regions ◽  
Global Pandemic ◽  
The World ◽  
Molecular Studies ◽  
Widespread Availability ◽  
Rapid Transfer

Abstract The world is facing a global pandemic of COVID-19 caused by the SARS-CoV-2 coronavirus. Here we describe a collection of codon-optimized coding sequences for SARS-CoV-2 cloned into Gateway-compatible entry vectors, which enable rapid transfer into a variety of expression and tagging vectors. The collection is freely available. We hope that widespread availability of this SARS-CoV-2 resource will enable many subsequent molecular studies to better understand the viral life cycle and how to block it.

scholarly journals FORECASTS FOR THE FUTURE OF WORK THAT THE COVID-19 PANDEMIC ANTICIPATED AND ITS MAIN REPERCUSSIONS

2021 ◽  
Vol 2 (5) ◽  
pp. e25294
Author(s):  
Aline Cavalcante Santana
Keyword(s):  
Government Agencies ◽  
Health Crisis ◽  
Future Of Work ◽  
Global Pandemic ◽  
The World ◽  
The Future

The pandemic of the COVID-19 virus brought several changes, including those that shook the world of work. Some transformations were already in progress and others were expected at a later time, leading us to believe that this health crisis would have had an impact on the estimated forecasts for the future of work. This article proposes to outline a reflection on the world of work in the future, considering as a reference the changes that are already in force and comparing them to the predictions highlighted for the decade from 2018 to 2028 through great theoretical references in the areas related to the management of people and technology. The conclusions expose a truth that, in practice, can be inconvenient: this global pandemic forced us to anticipate the agenda related to the future of work and the market - including companies, employees, government agencies and consumers - was not ready for this rupture.

scholarly journals Vaccines and Treatment of Coronavirus Disease 2019

2020 ◽  
Vol 95 (6) ◽  
pp. 364-369
Author(s):  
Pyoeng Gyun Choe
Keyword(s):  
Clinical Trial ◽  
Clinical Trials ◽  
Antiviral Agents ◽  
World Health ◽  
Rna Dependent Rna Polymerase ◽  
Global Pandemic ◽  
The World ◽  
Polymerase Inhibitor ◽  
Experimental Treatments ◽  
Health Organization

In December 2019, a new strain of betacoronavirus, severe acute respiratory syndrome coronavirus 2, which causes coronavirus disease 2019 (COVID-19), emerged in Wuhan, China. Subsequently, the virus quickly spread worldwide and the World Health Organization declared COVID-19 a global pandemic on March 11, 2020. In response to the pandemic, many researchers are working on repurposing existing drugs to alter the course of severe COVID-19, and are testing experimental treatments. Among antiviral agents, remdesivir, an RNA-dependent RNA polymerase inhibitor, showed clinical benefit in a randomized clinical trial. In October 2020, the Food and Drug Administration approved remdesivir for treating hospitalized patients with COVID-19, making it the first drug approved for the disease. The race to produce safe, effective vaccines is also progressing at unprecedented speed, with over 200 under development and 45 candidates already being tested in human clinical trials (as of October 2020).

scholarly journals Garlic (Allium sativum L.): a potential unique therapeutic food rich in organosulfur and flavonoid compounds to fight with COVID-19

2020 ◽  
Vol 19 (1) ◽  
Author(s):  
Sucheta Khubber ◽  
Reza Hashemifesharaki ◽  
Mehrdad Mohammadi ◽  
Seyed Mohammad Taghi Gharibzahedi
Keyword(s):  
Active Site ◽  
Allium Sativum ◽  
Wide Spectrum ◽  
Immunomodulatory Effects ◽  
Replication Process ◽  
Health Crisis ◽  
Major Health ◽  
Therapeutic Drugs ◽  
The World ◽  
Therapeutic Food

AbstractCoronavirus disease 2019 (COVID-19) is the current major health crisis in the world. A successful strategy to combat the COVID-19 pandemic is the improvement of nutritional pattern. Garlic is one of the most efficient natural antibiotics against the wide spectrum of viruses and bacteria. Organosulfur (e.g., allicin and alliin) and flavonoid (e.g., quercetin) compounds are responsible for immunomodulatory effects of this healthy spice. The viral replication process is accelerated with the main structural protease of SARS-CoV-2. The formation of hydrogen bonds between this serine-type protease and garlic bioactives in the active site regions inhibits the COVID-19 outbreak. The daily dietary intake of garlic and its derived-products as an adjuvant therapy may improve side effects and toxicity of the main therapeutic drugs with reducing the used dose.

scholarly journals USE OF GLYCOPYRROLATE AS AN ADJUNCT FOR REDUCTION OF AEROSOL TRANSMISSION OF COVID-19 DURING DENTAL PROCEDURES: A HYPOTHESIS

2020 ◽  
Vol 8 (10) ◽  
pp. 1319-1324
Author(s):  
Rajesh Kumar Routray ◽  
◽  
Kamal Kanta Satapathy ◽  
J. Nitin Samuel ◽  
Ajay Reddy Palle ◽  
...  
Keyword(s):  
Health Care Professionals ◽  
Salivary Secretion ◽  
Health Crisis ◽  
Infection Transmission ◽  
Contagious Nature ◽  
Global Pandemic ◽  
Dental Procedures ◽  
The World ◽  
New Strategy ◽  
And Control

COVID-19 global pandemic has become the biggest challenge by causing health crisis across the world due to its contagious nature. Salivary gland acts as a reservoir of virus due to which contaminated saliva plays a pivotal role in COVID-19 transmission among humans. Infection transmission from symptomatic patients as well as asymptomatic carriers is inevitable while performing aerosol generating procedures because contaminated aerosols have potential to float in the air for a considerable amount of time and be inhaled by dentist, dental auxiliary and other patients. Hence, it is a matter of utmost importance to keep upgrading the strategies for prevention of transmission as the outbreak of SARS-COV 2 has clearly placed the health care professionals at highest risk. As excess salivary secretion results in more aerosol contamination in dental procedures, leading to higher risk of transmission antisialogogues can be used to reduce salivary production. This new strategy will be helpful towards reducing aerosol transmission inorder to prevent and control the spread of this highly infectious disease. The aim of this present review is to propose the possible use of antisialogogues (glycopyrrolates) as an adjunct aid in reducing the risk of transmission from contaminated aerosols.

scholarly journals Probable immersions for novel Coronavirus and its preventions: A systematic review

2020 ◽  
Author(s):  
Parth M. Kapatel ◽  
Nagma ara Malik
Keyword(s):  
Antiviral Agents ◽  
Severe Infection ◽  
Control Measures ◽  
Health Crisis ◽  
Infection Control Measures ◽  
New Public Health ◽  
New Public ◽  
The World ◽  
Novel Coronavirus

The new public health crisis threatening the world with the emergence due to the spreading of 2019 novel coronavirus (2019-nCoV) or it can also say as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The virus instigated in bats and was transmitted to humans through yet unknown transitional animals in Wuhan, Hubei province, China in December 2019. There have been around 3.04 million reported cases by WHO of coronavirus disease 2019 (COVID-2019) and 895 thousand are recovered, 211 thousand reported deaths to date (28/04/2020) from all over the world. The disease is spread by inhalation/breathing or interaction with infected droplets. The quarantine period ranges from 2 to 14 days. The symptoms are typically breathlessness, cough, sore throat, fever, fatigue, malaise, among others. The disease is mild in most people; while in about some (generally the aged and those with comorbidities), it may progress to pneumonia, acute respiratory distress syndrome (ARDS) and multi-organ dysfunction. Many people are asymptomatic. Treatment is very essentially supportive; the role of antiviral agents is up till now to be recognized. Prevention requires home quarantine of alleged cases and those with mild illnesses and severe infection control measures at hospitals that contain interaction, touch and droplet precautions.

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