scholarly journals A Comprehensive, Flexible Collection of SARS-CoV-2 Coding Regions

2020 ◽  
Vol 10 (9) ◽  
pp. 3399-3402 ◽  
Author(s):  
Dae-Kyum Kim ◽  
Jennifer J Knapp ◽  
Da Kuang ◽  
Aditya Chawla ◽  
Patricia Cassonnet ◽  
...  
Keyword(s):  
Life Cycle ◽  
Viral Life Cycle ◽  
Coding Sequences ◽  
Coding Regions ◽  
Global Pandemic ◽  
The World ◽  
Molecular Studies ◽  
Widespread Availability ◽  
Rapid Transfer

Abstract The world is facing a global pandemic of COVID-19 caused by the SARS-CoV-2 coronavirus. Here we describe a collection of codon-optimized coding sequences for SARS-CoV-2 cloned into Gateway-compatible entry vectors, which enable rapid transfer into a variety of expression and tagging vectors. The collection is freely available. We hope that widespread availability of this SARS-CoV-2 resource will enable many subsequent molecular studies to better understand the viral life cycle and how to block it.

scholarly journals A Flexible Genome-Scale SARS-CoV-2 Clone Resource

2020 ◽  
Author(s):  
Dae-Kyum Kim ◽  
Jennifer J. Knapp ◽  
Da Kuang ◽  
Aditya Chawla ◽  
Patricia Cassonnet ◽  
...  
Keyword(s):  
Antiviral Agents ◽  
Health Crisis ◽  
Major Health ◽  
Coding Sequences ◽  
Global Pandemic ◽  
The World ◽  
Flexible Genome ◽  
Widespread Availability ◽  
Genome Scale ◽  
Rapid Transfer

The world is facing a major health crisis, the global pandemic of COVID-19 caused by the SARS-CoV-2 coronavirus, for which no approved antiviral agents or vaccines are currently available. Here we describe a collection of codon-optimized coding sequences for SARS-CoV-2 cloned into Gateway-compatible entry vectors, which enable rapid transfer into a variety of expression and tagging vectors. The collection is freely available via Addgene. We hope that widespread availability of this SARS-CoV-2 resource will enable many subsequent molecular studies to better understand the viral life cycle and how to block it.

scholarly journals A Flexible Genome-Scale Resource of SARS-CoV-2 Coding Sequence Clones

2020 ◽  
Author(s):  
Dae-Kyum Kim ◽  
Jennifer J. Knapp ◽  
Da Kuang ◽  
Patricia Cassonnet ◽  
Payman Samavarchi-Tehrani ◽  
...  
Keyword(s):  
Antiviral Agents ◽  
Health Crisis ◽  
Major Health ◽  
Coding Sequences ◽  
Global Pandemic ◽  
The World ◽  
Flexible Genome ◽  
Widespread Availability ◽  
Genome Scale ◽  
Rapid Transfer

The world is facing a major health crisis, the global pandemic of COVID-19 caused by the SARS-CoV-2 coronavirus, for which no approved antiviral agents or vaccines are currently available. Here we describe a collection of codon-optimized coding sequences for SARS-CoV-2 cloned into Gateway-compatible entry vectors, which enable rapid transfer into a variety of expression and tagging vectors. The collection is freely available via Addgene. We hope that widespread availability of this SARS-CoV-2 resource will enable many subsequent molecular studies to better understand the viral life cycle and how to block it.

scholarly journals A Flexible Genome-Scale Resource of SARS-CoV-2 Coding Sequence Clones

2020 ◽  
Author(s):  
Dae-Kyum Kim ◽  
Jennifer J. Knapp ◽  
Da Kuang ◽  
Patricia Cassonnet ◽  
Payman Samavarchi-Tehrani ◽  
...  
Keyword(s):  
Antiviral Agents ◽  
Health Crisis ◽  
Major Health ◽  
Coding Sequences ◽  
Global Pandemic ◽  
The World ◽  
Flexible Genome ◽  
Widespread Availability ◽  
Genome Scale ◽  
Rapid Transfer

The world is facing a major health crisis, the global pandemic of COVID-19 caused by the SARS-CoV-2 coronavirus, for which no approved antiviral agents or vaccines are currently available. Here we describe a collection of codon-optimized coding sequences for SARS-CoV-2 cloned into Gateway-compatible entry vectors, which enable rapid transfer into a variety of expression and tagging vectors. The collection is freely available via Addgene. We hope that widespread availability of this SARS-CoV-2 resource will enable many subsequent molecular studies to better understand the viral life cycle and how to block it.

scholarly journals A Flexible Genome-Scale SARS-CoV-2 Clone Resource

2020 ◽  
Author(s):  
Dae-Kyum Kim ◽  
Jennifer J. Knapp ◽  
Da Kuang ◽  
Aditya Chawla ◽  
Patricia Cassonnet ◽  
...  
Keyword(s):  
Antiviral Agents ◽  
Health Crisis ◽  
Major Health ◽  
Coding Sequences ◽  
Global Pandemic ◽  
The World ◽  
Flexible Genome ◽  
Widespread Availability ◽  
Genome Scale ◽  
Rapid Transfer

The world is facing a major health crisis, the global pandemic of COVID-19 caused by the SARS-CoV-2 coronavirus, for which no approved antiviral agents or vaccines are currently available. Here we describe a collection of codon-optimized coding sequences for SARS-CoV-2 cloned into Gateway-compatible entry vectors, which enable rapid transfer into a variety of expression and tagging vectors. The collection is freely available via Addgene. We hope that widespread availability of this SARS-CoV-2 resource will enable many subsequent molecular studies to better understand the viral life cycle and how to block it.

scholarly journals A Flexible Genome-Scale SARS-CoV-2 Clone Resource

2020 ◽  
Author(s):  
Dae-Kyum Kim ◽  
Jennifer J. Knapp ◽  
Da Kuang ◽  
Aditya Chawla ◽  
Patricia Cassonnet ◽  
...  
Keyword(s):  
Antiviral Agents ◽  
Health Crisis ◽  
Major Health ◽  
Coding Sequences ◽  
Global Pandemic ◽  
The World ◽  
Flexible Genome ◽  
Widespread Availability ◽  
Genome Scale ◽  
Rapid Transfer

The world is facing a major health crisis, the global pandemic of COVID-19 caused by the SARS-CoV-2 coronavirus, for which no approved antiviral agents or vaccines are currently available. Here we describe a collection of codon-optimized coding sequences for SARS-CoV-2 cloned into Gateway-compatible entry vectors, which enable rapid transfer into a variety of expression and tagging vectors. The collection is freely available via Addgene. We hope that widespread availability of this SARS-CoV-2 resource will enable many subsequent molecular studies to better understand the viral life cycle and how to block it.

scholarly journals Global Pandemic as a Result of Severe Acute Respiratory Syndrome Coronavirus 2 Outbreak: A Biomedical Perspective

2021 ◽  
Author(s):  
Charles Arvind Sethuraman Vairavan ◽  
Devarani Rameshnathan ◽  
Nagaraja Suryadevara ◽  
Gnanendra Shanmugam
Keyword(s):  
Life Cycle ◽  
Severe Acute Respiratory Syndrome ◽  
Clinical Manifestations ◽  
World Health Organisation ◽  
Laboratory Diagnosis ◽  
Viral Life Cycle ◽  
World Health ◽  
The Public ◽  
Global Pandemic ◽  
Novel Coronavirus

In December 2019, a novel coronavirus had emerged in Wuhan city, China that led to an outbreak resulting in a global pandemic, taking thousands of lives. The infectious virus was later classified as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Individuals infected by this novel virus initially exhibit nonspecific symptoms such as dry cough, fever, dizziness and many more bodily complications. From the “public health emergency of international concern” declaration by the World Health Organisation (WHO), several countries have taken steps in controlling the transmission and many researchers share their knowledge on the SARS-COV-2 characteristics and viral life cycle, that may aid in pharmaceutical and biopharmaceutical companies to develop SARS-CoV-2 vaccine and antiviral drugs that interfere with the viral life cycle. In this literature review the origin, classification, aetiology, life cycle, clinical manifestations, laboratory diagnosis and treatment are all reviewed.

scholarly journals Hepatitis C--new developments in the studies of the viral life cycle.

2007 ◽  
Vol 54 (4) ◽  
pp. 703-715 ◽  
Author(s):  
Małgorzata Rychłowska ◽  
Krystyna Bieńkowska-Szewczyk
Keyword(s):  
Cell Culture ◽  
Life Cycle ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Culture System ◽  
Viral Life Cycle ◽  
Model Systems ◽  
World Population ◽  
Cell Culture System ◽  
The World

Hepatitis C virus (HCV) is a causative agent of chronic liver disease leading to cirrhosis, liver failure and hepatocellular carcinoma. The prevalence of HCV is estimated as 3% of the world population and the virus is a major public health problem all over the world. For over 16 years, since HCV had been discovered, studies of the mechanisms of the viral life cycle and virus-host interactions have been hampered by the lack of a cell culture system allowing the virus to be grown in laboratory conditions. However, in recent years some new model systems to study HCV have been developed. The major breakthrough of the last two years was the cell culture system for maintaining the virus in an adapted hepatocyte-derived cell line. This review describes the techniques and applications of most of the in vitro systems and animal models currently used for working with hepatitis C virus.

The relevance of dietetic approach of Ayurveda from the perspective of COVID-19 pandemic

2020 ◽  
Vol 11 (SPL1) ◽  
pp. 748-752
Author(s):  
Swapnali Khabade ◽  
Bharat Rathi ◽  
Renu Rathi
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Healthy Person ◽  
World Health ◽  
Physical And Mental Health ◽  
Leading Role ◽  
Global Pandemic ◽  
The People ◽  
The World ◽  
Health Organization ◽  
The Individual

A novel, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), causes severe acute respiratory syndrome and spread globally from Wuhan, China. In March 2020 the World Health Organization declared the SARS-Cov-2 virus as a COVID- 19, a global pandemic. This pandemic happened to be followed by some restrictions, and specially lockdown playing the leading role for the people to get disassociated with their personal and social schedules. And now the food is the most necessary thing to take care of. It seems the new challenge for the individual is self-isolation to maintain themselves on the health basis and fight against the pandemic situation by boosting their immunity. Food organised by proper diet may maintain the physical and mental health of the individual. Ayurveda aims to promote and preserve the health, strength and the longevity of the healthy person and to cure the disease by properly channelling with and without Ahara. In Ayurveda, diet (Ahara) is considered as one of the critical pillars of life, and Langhana plays an important role too. This article will review the relevance of dietetic approach described in Ayurveda with and without food (Asthavidhi visheshaytana & Lanhgan) during COVID-19 like a pandemic.

Dietary and living regimen of covid-19 with special reference to Ayurveda Varsha and Sharad Ritucharya

2020 ◽  
Vol 11 (SPL1) ◽  
pp. 758-762
Author(s):  
Amit Biswas ◽  
KunalChandankhede
Keyword(s):  
Environmental Changes ◽  
World Health ◽  
Human Beings ◽  
Dietary Regimen ◽  
Global Pandemic ◽  
The World ◽  
Health Organization ◽  
Disease Free ◽  
Individual Disease ◽  
Morbid Conditions

Wuhan originated Covid-19 disease is caused by SARC-COV 2 virus. It is a contagious disease it spread all over the world. World health organization declared a global pandemic disease. In Covid-19 immunity plays an important role. In old age people or having other co-morbid conditions the mortality rate is more. Ayurveda has a big role in improved immunity or to intact immunity. The principle of Ayurveda is to keep individual swastha (diseases free). To maintain individual disease-free Ritucharya is one of the important subjects of Ayurveda. Aimed of study is to find out Ritucharya literature from the Ayurveda and modern research specifically Varsha and Sharad ritu. Ritucharya contains dietary regimen, living modification, common medicine, and contraindicated things those changing according to environmental change. Upcoming season in India is Varsha and Sharad ritu. Environmental changes are huge in this season and it directly affected human beings. So this study reveals property of ritu, dietary regimen, living modification, common medicine and contraindicated things in upcoming varsha and sharad ritu.

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