Task-fMRI Group and Functional Connectivity Analysis of the Brain During Faradarmani Consciousness Field Connection

Task fMRI has played a critical role in recognizing the specific functions of the different regions of human brain during various cognitive activities. This study aimed to investigate group analysis and functional connectivity in the Faradarmangars brain during the Faradarmani CF (FCF) connection. Using task functional MRI (task-fMRI), we attempted the identification of different activated and deactivated brain regions during the Consciousness Filed connection. Clusters that showed significant differences in peak intensity between task and rest group were selected as seeds for seed-voxel analysis. Connectivity of group differences in functional connectivity analysis was determined following each activation and deactivation network. In this study, we report the fMRI-based representation of the FCF connection at the human brain level. The group analysis of FCF connection task revealed activation of frontal lobe (BA6/BA10/BA11). Moreover, seed based functional connectivity analysis showed decreased connectivity within activated clusters and posterior Cingulate Gyrus (BA31). Moreover, we observed an increased connectivity within deactivated clusters and frontal lobe (BA11/BA47) during the FCF connection. Activation clusters as well as the increased and decreased connectivity between different regions of the brain during the FCF connection, firstly, validates the significant effect of the FCF and secondly, indicates a distinctive pattern of connection with this non-material and non-energetic field, in the brain.

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Brain hubs defined in the group do not overlap with regions of high inter-individual variability

10.1101/2021.10.17.464723 ◽

2021 ◽

Author(s):

Derek Martin Smith ◽

Brian T Kraus ◽

Ally Dworetsky ◽

Evan M Gordon ◽

Caterina Gratton

Keyword(s):

Functional Connectivity ◽

Brain Function ◽

Critical Role ◽

Brain Regions ◽

Individual Variability ◽

Spatial Proximity ◽

Functional Magnetic Resonance ◽

Multiple Networks ◽

Human Connectome Project ◽

The Brain

Connector 'hubs' are brain regions with links to multiple networks. These regions are hypothesized to play a critical role in brain function. While hubs are often identified based on group-average functional magnetic resonance imaging (fMRI) data, there is considerable inter-subject variation in the functional connectivity profiles of the brain, especially in association regions where hubs tend to be located. Here we investigated how group hubs are related to locations of inter-individual variability, to better understand if hubs are (a) relatively conserved across people, (b) locations with malleable connectivity, leading individuals to show variable hub profiles, or (c) artifacts arising from cross-person variation. To answer this question, we compared the locations of hubs and regions of strong idiosyncratic functional connectivity ("variants") in both the Midnight Scan Club and Human Connectome Project datasets. Group hubs defined based on the participation coefficient did not overlap strongly with variants. These hubs have relatively strong similarity across participants and consistent cross-network profiles. Consistency across participants was further improved when participation coefficient hubs were allowed to shift slightly in local position. Thus, our results demonstrate that group hubs defined with the participation coefficient are generally consistent across people, suggesting they may represent conserved cross-network bridges. More caution is warranted with alternative hub measures, such as community density, which are based on spatial proximity and show higher correspondence to locations of individual variability.

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Disrupted stepwise functional brain organization in overweight individuals

Communications Biology ◽

10.1038/s42003-021-02957-7 ◽

2022 ◽

Vol 5 (1) ◽

Author(s):

Hyebin Lee ◽

Junmo Kwon ◽

Jong-eun Lee ◽

Bo-yong Park ◽

Hyunjin Park

Keyword(s):

Functional Connectivity ◽

Eating Behaviors ◽

Brain Regions ◽

Healthy Weight ◽

Connectivity Analysis ◽

Brain Organization ◽

Attention Networks ◽

Functional Hierarchy ◽

Functional Brain Organization ◽

The Brain

AbstractFunctional hierarchy establishes core axes of the brain, and overweight individuals show alterations in the networks anchored on these axes, particularly in those involved in sensory and cognitive control systems. However, quantitative assessments of hierarchical brain organization in overweight individuals are lacking. Capitalizing stepwise functional connectivity analysis, we assess altered functional connectivity in overweight individuals relative to healthy weight controls along the brain hierarchy. Seeding from the brain regions associated with obesity phenotypes, we conduct stepwise connectivity analysis at different step distances and compare functional degrees between the groups. We find strong functional connectivity in the somatomotor and prefrontal cortices in both groups, and both converge to transmodal systems, including frontoparietal and default-mode networks, as the number of steps increased. Conversely, compared with the healthy weight group, overweight individuals show a marked decrease in functional degree in somatosensory and attention networks across the steps, whereas visual and limbic networks show an increasing trend. Associating functional degree with eating behaviors, we observe negative associations between functional degrees in sensory networks and hunger and disinhibition-related behaviors. Our findings suggest that overweight individuals show disrupted functional network organization along the hierarchical axis of the brain and these results provide insights for behavioral associations.

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