Imaging diagnostic methods in assessment of renal function in patients with kidney tumours

2020 ◽  
Vol 8 (1) ◽  
pp. 40-44
Author(s):  
K.R. Azilgareeva ◽  
◽  
A.V. Proskura ◽  
V.V. Borisov ◽  
M.M. Chernenky ◽  
...  
Keyword(s):  
Renal Function ◽  
Glomerular Filtration Rate ◽  
Key Words ◽  
Gold Standard ◽  
Diagnostic Tests ◽  
Filtration Rate ◽  
Diagnostic Methods ◽  
Comprehensive Information ◽  
Modern Methods

The article offers a review of modern methods of assessing renal function in patients with kidney tumours. At present, there are many methods of assessment of renal function, beginning with laboratory diagnostic tests and up to radionuclide diagnostic methods. Examination of glomerular filtration rate and the Rehberg-Tareev test are widespread and accessible methods, but they are not precise indicators and do not allow determination of the split renal function. Scintigraphy is a “gold standard” permitting to obtain comprehensive information about split renal, but it is a costly procedure. Contrast computered tomography might be a promising a method for assessing renal function during both the preoperative and postoperative periods. Key words: computered tomography, assessment of renal function, partial nephrectomy, scintigraphy

Transcutaneous measurement of renal function in conscious mice

2012 ◽  
Vol 303 (5) ◽  
pp. F783-F788 ◽  
Author(s):  
Andrea Schreiber ◽  
Yury Shulhevich ◽  
Stefania Geraci ◽  
Juergen Hesser ◽  
Dzmitry Stsepankou ◽  
...  
Keyword(s):  
Renal Function ◽  
Glomerular Filtration Rate ◽  
Filtration Rate ◽  
Plasma Clearance ◽  
Elimination Kinetics ◽  
Internal Memory ◽  
Freely Moving ◽  
Kinetics Of ◽  
Transcutaneous Measurement

Determination of glomerular filtration rate (GFR) in conscious mice is cumbersome for the experimenter and stressful for the animals. Here we report on a simple new technique allowing the transcutaneous measurement of GFR in conscious mice. This approach extends our previously developed technique for rats to mice. The technique relies on a miniaturized device equipped with an internal memory that permits the transcutaneous measurement of the elimination kinetics of the fluorescent renal marker FITC-sinistrin. This device is described and validated compared with FITC-sinistrin plasma clearance in healthy, unilaterally nephrectomized and pcy mice. In summary, we describe a technique allowing the measurement of renal function in freely moving mice independent of blood or urine sampling as well as of laboratory assays.

Clinical Renal Function Testing by External Double Isotope Monitoring Technique

1971 ◽  
Vol 10 (01) ◽  
pp. 16-24
Author(s):  
J. Fog Pedersen ◽  
M. Fog Pedersen ◽  
Paul Madsen
Keyword(s):  
Renal Function ◽  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Plasma Flow ◽  
Filtration Rate ◽  
Renal Plasma Flow ◽  
Correlation Coefficients ◽  
Feedback System ◽  
Effective Renal Plasma Flow ◽  
Advantages And Disadvantages

SummaryAn accurate catheter-free technique for clinical determination simultaneouslyof glomerular filtration rate and effective renal plasma flow by means of radioisotopes has been developed. The renal function is estimated by the amount of radioisotopes necessary to maintain a constant concentration in the patient’s blood. The infusion pumps are steered by a feedback system, the pumps being automatically turned on when the radiation measured over the patient’s head falls below a certain preset level and turned off when this level is again readied. 131I-iodopyracet was used for the estimation of effective renal plasma flow and125I-iothalamate estimation of the glomerular filtration rate. These clearances were compared to the conventional bladder clearances and good correlation was found between these two clearance methods (correlation coefficients 0.97 and.90 respectively). The advantages and disadvantages of this new clearance technique are discussed.

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