scholarly journals Electrochemical Investigation of Interaction of Candida albicans with Titanium-Nickel Implant in Human Saliva

2022 ◽  
pp. ArticleID:22028
Author(s):  
Bin Qiao ◽  
Keyword(s):  
Candida Albicans ◽  
Human Saliva ◽  
Electrochemical Investigation ◽  
Titanium Nickel

Detachment activity of human saliva in vitro for Candida albicans cells attached to a plastic plate

2003 ◽  
Vol 9 (3) ◽  
pp. 215-220 ◽  
Author(s):  
Yusuke Kamagata-Kiyoura ◽  
Toshimasa Nitta ◽  
Shigeru Abe ◽  
Hideyo Yamaguchi
Keyword(s):  
Candida Albicans ◽  
Human Saliva ◽  
Plastic Plate

scholarly journals The proteolytic potential of Candida albicans in human saliva supplemented with glucose

1984 ◽  
Vol 17 (1) ◽  
pp. 13-22 ◽  
Author(s):  
L. P. SAMARANAYAKE ◽  
A. HUGHES ◽  
T. W. MACFARLANE
Keyword(s):  
Candida Albicans ◽  
Human Saliva

scholarly journals Characterization of Candida albicans agglutinating factor in human saliva.

1985 ◽  
Vol 27 (4) ◽  
pp. 1238-1242
Author(s):  
Shogo Minagi ◽  
Yoichiro Miyake ◽  
Kohmei Kobayashi ◽  
Yasumasa Akagawa ◽  
Hiromichi Tsuru ◽  
...  
Keyword(s):  
Candida Albicans ◽  
Human Saliva

Candida albicans adherence to resin-composite restorative dental material: Influence of whole human saliva

2002 ◽  
Vol 94 (5) ◽  
pp. 589-592 ◽  
Author(s):  
José Luis Maza ◽  
Natalia Elguezabal ◽  
Carlota Prado ◽  
Joseba Ellacuría ◽  
Iñaki Soler ◽  
...  
Keyword(s):  
Candida Albicans ◽  
Resin Composite ◽  
Human Saliva ◽  
Dental Material

scholarly journals Effect of Concentration and Time on the Antimicrobial Activity of Human Saliva against Candida albicans

2019 ◽  
Vol 17 (3-4) ◽  
pp. 114-119
Author(s):  
Masanori Ono ◽  
Takehiro Watanabe ◽  
Suguru Kimoto ◽  
Ryoki Kobayashi ◽  
Tetsuro Kono ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Candida Albicans ◽  
Human Saliva

scholarly journals Effect of pH and human saliva on protease production by Candida albicans.

1981 ◽  
Vol 31 (1) ◽  
pp. 323-326 ◽  
Author(s):  
G R Germaine ◽  
L M Tellefson
Keyword(s):  
Candida Albicans ◽  
Human Saliva ◽  
Protease Production ◽  
Effect Of Ph

scholarly journals Histatin 5 Metallopeptides and Their Potential against Candida albicans Pathogenicity and Drug Resistance

Biomolecules ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 1209
Author(s):  
Gabriela Vieira Silva Zolin ◽  
Fauller Henrique da Fonseca ◽  
Carolina Reis Zambom ◽  
Saulo Santesso Garrido
Keyword(s):  
Candida Albicans ◽  
Systemic Infection ◽  
Resistance Mechanisms ◽  
Human Saliva ◽  
Antifungal Drugs ◽  
New Drugs ◽  
Correct Treatment ◽  
Histatin 5 ◽  
Effective Drugs ◽  
High Antifungal Activity

Usually caused by Candida albicans, buccal candidiasis begins with the morphological transition between yeast and hyphal cells. Over time and without the correct treatment, it can be disseminated through the bloodstream becoming a systemic infection with high mortality rates. C. albicans already shows resistance against antifungals commonly used in treatments. Therefore, the search for new drugs capable of overcoming antifungal resistance is essential. Histatin 5 (Hst5) is an antimicrobial peptide of the Histatin family, that can be found naturally in human saliva. This peptide presents high antifungal activity against C. albicans. However, Hst5 action can be decreased for interaction with enzymes and metal ions present in the oral cavity. The current work aims to bring a brief review of relevant aspects of the pathogenesis and resistance mechanisms already reported for C. albicans. In addition, are also reported here the main immune responses of the human body and the most common antifungal drugs. Finally, the most important aspects regarding Histatin 5 and the benefits of its interaction with metals are highlighted. The intention of this review is to show the promising use of Hst5 metallopeptides in the development of effective drugs.

Effects of histatin 5 and derived peptides on Candida albicans

2001 ◽  
Vol 356 (2) ◽  
pp. 361-368 ◽  
Author(s):  
Anita L. A. RUISSEN ◽  
Jasper GROENINK ◽  
Eva J. HELMERHORST ◽  
Els WALGREEN-WETERINGS ◽  
Wim van't HOF ◽  
...  
Keyword(s):  
Candida Albicans ◽  
Mitochondrial Membrane ◽  
Cytoplasmic Membrane ◽  
Human Saliva ◽  
Mitochondrial Activity ◽  
Complete Protection ◽  
Destructive Effect ◽  
Histatin 5 ◽  
Killing Activity ◽  
Anti Fungal

Three anti-microbial peptides were compared with respect to their killing activity against Candida albicans and their ability to disturb its cellular and internal membranes. Histatin 5 is an anti-fungal peptide occurring naturally in human saliva, while dhvar4 and dhvar5 are variants of its active domain, with increased anti-microbial activity. dhvar4has increased amphipathicity compared with histatin 5, whereas dhvar5has amphipathicity comparable with that of histatin 5. All three peptides caused depolarization of the cytoplasmic and/or mitochondrial membrane, indicating membranolytic activity. For the variant peptides both depolarization and killing occurred at a faster rate. With FITC-labelled peptides, no association with the cytoplasmic membrane was observed, contradicting the formation of permanent transmembrane multimeric peptide pores. Instead, the peptides were internalized and act on internal membranes, as demonstrated with mitochondrion- and vacuole-specific markers. In comparison with histatin 5, the variant peptides showed a more destructive effect on mitochondria. Entry of the peptides and subsequent killing were dependent on the metabolic state of the cells. Blocking of the mitochondrial activity led to complete protection against histatin 5 activity, whereas that of dhvar4 was hardly affected and that of dhvar5 was affected only intermediately.

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