Three-Dimensional Reconstruction by Time-Domain Optical Coherence Tomography Microscope with Improved Measurement Range

2017 ◽  
Vol 11 (5) ◽  
pp. 787-794
Author(s):  
Shin Usuki ◽  
Katsuaki Tamaki ◽  
Kenjiro T. Miura ◽  
◽  
Keyword(s):  
Optical Coherence Tomography ◽  
3D Reconstruction ◽  
Time Domain ◽  
Interference Fringe ◽  
Measurement Accuracy ◽  
Three Dimensional ◽  
Measurement Range ◽  
Optical Coherence ◽  
Reference Mirror ◽  
Low Coherence

The objective of this research was to develop a three-dimensional (3D) reconstruction system based on a time-domain optical coherence tomography (OCT) microscope. One of the critical drawbacks of OCT microscopes is that their axial measurement ranges are typically limited by their depths of field (DOFs), which are determined by the numerical apertures of their objective lenses and the central wavelengths of their light sources. If a low-coherence interference fringe is far outside the DOF, the measurement accuracy inevitably decreases, regardless of how well-adjusted the reference mirror is. To address this issue and improve the axial measurement range of the OCT microscope in this study, an object-scanning measurement scheme involving a Linnik interferometer was developed. To calibrate the system in the proposed technique, image post-processing is performed for a well-conditioned state to ensure that a low-coherence interference fringe is generated within the DOF, enabling 3D objects with high-aspect-ratio structures to be scanned along the axial direction. During object-scanning, this state is always monitored and is corrected by adjusting the reference mirror. By using this method, the axial measurement range can be improved up to the working distance (WD) of the objective lens without compromising the measurement accuracy. The WD is typically longer than 10 mm, while the DOF of the microscope is around 0.01 mm in general, although it varies depending on the imaging system. In this report, the experimental setup of a 3D reconstruction system is presented, a series of experimental verifications is described, and the results are discussed. The axial measurement range was improved to at least 35 times that of a typical OCT microscope with identical imaging optics.

Mobile Optical Coherence Tomography Sensor for Surface Layers Testing

2012 ◽  
Vol 518 ◽  
pp. 201-210
Author(s):  
Sławomir Tomczewski ◽  
Leszek Salbut
Keyword(s):  
Optical Coherence Tomography ◽  
Measurement Range ◽  
Optical Coherence ◽  
Surface Layers ◽  
Reference Mirror ◽  
Fringe Contrast ◽  
Contrast Analysis ◽  
Smart Pixel ◽  
Compact Design ◽  
Axial Scanning

In the paper the new type of mobile sensor based on optical coherence tomography is presented. For increasing the measurement range the special dynamic focusing system which moves imaging plane during axial scanning process is used. Therefore developed system allows focusing on measured layer. Additionally, for image analysis the special type of CMOS matrix (called smart-pixel camera), synchronized with a reference mirror transducer, is applied. Due to hardware realization of a fringe contrast analysis simultaneously in each pixel with high frequency, the time of measurement decreases significantly. These advantages together with a compact design allow the sensor to be used as the mobile device for measurements of surface topography, thickness of surface layers and subsurface defects detection in laboratory, workshop and out-door conditions. Calibration of the designed sensor and its application to the technological measurements of the sticker label layers are presented and discussed.

scholarly journals 3D reconstruction of coronary artery bifurcations from coronary angiography and optical coherence tomography: feasibility, validation, and reproducibility

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Wei Wu ◽  
Saurabhi Samant ◽  
Gijs de Zwart ◽  
Shijia Zhao ◽  
Behram Khan ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Coronary Artery ◽  
3D Reconstruction ◽  
Three Dimensional ◽  
Plaque Burden ◽  
Patient Specific ◽  
Optical Coherence ◽  
Micro Computed Tomography ◽  
Processing Times ◽  
Mean Differences

Abstract The three-dimensional (3D) representation of the bifurcation anatomy and disease burden is essential for better understanding of the anatomical complexity of bifurcation disease and planning of stenting strategies. We propose a novel methodology for 3D reconstruction of coronary artery bifurcations based on the integration of angiography, which provides the backbone of the bifurcation, with optical coherence tomography (OCT), which provides the vessel shape. Our methodology introduces several technical novelties to tackle the OCT frame misalignment, correct positioning of the OCT frames at the carina, lumen surface reconstruction, and merging of bifurcation lumens. The accuracy and reproducibility of the methodology were tested in n = 5 patient-specific silicone bifurcations compared to contrast-enhanced micro-computed tomography (µCT), which was used as reference. The feasibility and time-efficiency of the method were explored in n = 7 diseased patient bifurcations of varying anatomical complexity. The OCT-based reconstructed bifurcation models were found to have remarkably high agreement compared to the µCT reference models, yielding r2 values between 0.91 and 0.98 for the normalized lumen areas, and mean differences of 0.005 for lumen shape and 0.004 degrees for bifurcation angles. Likewise, the reproducibility of our methodology was remarkably high. Our methodology successfully reconstructed all the patient bifurcations yielding favorable processing times (average lumen reconstruction time < 60 min). Overall, our method is an easily applicable, time-efficient, and user-friendly tool that allows accurate and reproducible 3D reconstruction of coronary bifurcations. Our technique can be used in the clinical setting to provide information about the bifurcation anatomy and plaque burden, thereby enabling planning, education, and decision making on bifurcation stenting.

Three-dimensional retinal blood flow analysis using joint spectral and time domain optical coherence tomography

2009 ◽  
Author(s):  
Anna Szkulmowska ◽  
Maciej Szkulmowski ◽  
Daniel Szlag ◽  
Danuta Bukowska ◽  
Szymon Tamborski ◽  
...  
Keyword(s):  
Blood Flow ◽  
Optical Coherence Tomography ◽  
Time Domain ◽  
Flow Analysis ◽  
Three Dimensional ◽  
Retinal Blood Flow ◽  
Optical Coherence ◽  
Blood Flow Analysis

scholarly journals Non-invasive three-dimensional thickness analysis of oral epithelium based on optical coherence tomography—development and diagnostic performance

Heliyon ◽  
2021 ◽  
Vol 7 (4) ◽  
pp. e06645
Author(s):  
Charlotte Theresa Trebing ◽  
Sinan Sen ◽  
Stefan Rues ◽  
Christopher Herpel ◽  
Maria Schöllhorn ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Diagnostic Performance ◽  
Three Dimensional ◽  
Oral Epithelium ◽  
Optical Coherence ◽  
Non Invasive

scholarly journals Three-dimensional segmentation and depth-encoded visualization of choroidal vasculature using swept-source optical coherence tomography

2021 ◽  
pp. 153537022110285
Author(s):  
Hao Zhou ◽  
Tommaso Bacci ◽  
K Bailey Freund ◽  
Ruikang K Wang
Keyword(s):  
Optical Coherence Tomography ◽  
Three Dimensional ◽  
Age Related Macular Degeneration ◽  
Optical Coherence ◽  
Full Thickness ◽  
Swept Source ◽  
Automated Method ◽  
Choroidal Imaging ◽  
Choroidal Vasculature ◽  
Choroidal Vessels

The choroid provides nutritional support for the retinal pigment epithelium and photoreceptors. Choroidal dysfunction plays a major role in several of the most important causes of vision loss including age-related macular degeneration, myopic degeneration, and pachychoroid diseases such as central serous chorioretinopathy and polypoidal choroidal vasculopathy. We describe an imaging technique using depth-resolved swept-source optical coherence tomography (SS-OCT) that provides full-thickness three-dimensional (3D) visualization of choroidal anatomy including topographical features of individual vessels. Enrolled subjects with different clinical manifestations within the pachychoroid disease spectrum underwent 15 mm × 9 mm volume scans centered on the fovea. A fully automated method segmented the choroidal vessels using their hyporeflective lumens. Binarized choroidal vessels were rendered in a 3D viewer as a vascular network within a choroidal slab. The network of choroidal vessels was color depth-encoded with a reference to the Bruch’s membrane segmentation. Topographical features of the choroidal vasculature were characterized and compared with choroidal imaging obtained with indocyanine green angiography (ICGA) from the same subject. The en face SS-OCT projections of the larger choroid vessels closely resembled to that obtained with ICGA, with the automated SS-OCT approach proving additional depth-encoded 3D information. In 16 eyes with pachychoroid disease, the SS-OCT approach added clinically relevant structural details, including choroidal thickness and vessel depth, which the ICGA studies could not provide. Our technique appears to advance the in vivo visualization of the full-thickness choroid, successfully reveals the topographical features of choroidal vasculature, and shows potential for further quantitative analysis when compared with other choroidal imaging techniques. This improved visualization of choroidal vasculature and its 3D structure should provide an insight into choroid-related disease mechanisms as well as their responses to treatment.

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