scholarly journals A single-institutional analysis of racial disparities in clinicopathologic characteristics, treatment selections, and outcomes in advanced-stage pancreatic cancer patients

2021 ◽  
Vol 0 ◽  
pp. 0-0
Author(s):  
Matthew Williams ◽  
Umut Özbek ◽  
Jung-Yi Lin ◽  
Celina Ang
Keyword(s):  
Pancreatic Cancer ◽  
Racial Disparities ◽  
Cancer Patients ◽  
Institutional Analysis ◽  
Advanced Stage ◽  
Clinicopathologic Characteristics

Why African Americans are more predisposed to pancreatic cancer: Nature versus nurture.

2013 ◽  
Vol 31 (15_suppl) ◽  
pp. e15018-e15018
Author(s):  
Wesley Thompson ◽  
Naeem Latif ◽  
Robert Rahberg
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Pancreatic Cancer ◽  
African American ◽  
African Americans ◽  
Cancer Patients ◽  
Mortality Risk ◽  
African American Females ◽  
Advanced Stage ◽  
Stage At Diagnosis

e15018 Background: There are known risk factors for pancreatic cancer like diabetes mellitus; cigarette smoking; poverty, and alcoholism; all of which are more common in African American patients than the general population. The purpose was to determine if these established risk factors were more associated within African American pancreatic cancer patients to explain their 50 – 90% increased incidence in the U.S. population. Methods: This retrospective study reviewed 172 biopsy-proven pancreatic cancer patients diagnosed over ten years at University of Florida Jacksonville. We employed linear regression models to determine statistical significance of established risk factors with prevalence of pancreatic cancer among cohorts. Results: Our data showed no increased association of diabetes, tobacco use, alcohol use between African Americans and Caucasians. However, Africans Americans as a group were twice as likely to be found at stage III or IV upon diagnosis, conferring an increased mortality risk (OR = 2.2, (95% CI 1.1 – 4.39)). Among these African Americans at advanced stage of diagnosis, females were at triple risk by odds ratio to be underinsured compared to Caucasian males (OR = 3.1, (95% CI 1.29 – 7.49, p = 0.015)). African American females were almost twice as likely to be underinsured compared to Caucasian females (OR = 1.72, (95% CI 0.646, 4.558)). The lack of healthcare access maybe related to advanced stage at diagnosis and its increased mortality risk. Conclusions: Our data suggests that the risk factors of smoking, alcoholism, and diabetes mellitus alone do not explain African Americans’ propensity for pancreatic cancer. However, lack of health insurance does confer an advanced stage at diagnosis and increased mortality risk among African American females. Our data also suggests that other etiological factors such as genetics maybe be associated with the increased risk amongst African Americans. A further investigation is warranted into genetic etiologies since African American patients have higher incidence of K-ras mutations than Caucasians; and mutated K-ras has been associated with pancreatic cancer, which is a target for therapy.

Abstract C091: Racial disparities in pancreatic cancer pancreatic cancer patients in Florida and an investigation into a possible role of cancer cachexia

2020 ◽  
Author(s):  
Patrick Underwood ◽  
Miles Cameron ◽  
Ashley Clark Daly ◽  
Tracey Barnett ◽  
Clement Gwede ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Racial Disparities ◽  
Cancer Patients ◽  
Cancer Cachexia

scholarly journals The Association between Body Composition and Overall Survival of Advanced Stage Pancreatic Cancer Patients Treated with FOLFIRINOX

HPB ◽  
2021 ◽  
Vol 23 ◽  
pp. S929-S930
Author(s):  
M. Aberle ◽  
G. Wenmaekers ◽  
J. De Vos - Geelen ◽  
D. Bogers ◽  
M. Coolsen ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Overall Survival ◽  
Body Composition ◽  
Cancer Patients ◽  
Advanced Stage

FEASIBILITY OF ORAL AND DUODENAL MICROBIOTA ANALYSIS OF PANCREATIC CANCER PATIENTS AND CONTROLS

2020 ◽  
Author(s):  
L Archibugi ◽  
MC Petrone ◽  
G Rossi ◽  
A Mariani ◽  
SGG Testoni ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Patients ◽  
Microbiota Analysis

scholarly journals Circulating cytokine levels as biomarkers for response to FOLFIRINOX chemotherapy in pancreatic cancer patients

HPB ◽  
2021 ◽  
Vol 23 ◽  
pp. S233-S234
Author(s):  
F. van der Sijde ◽  
W. Dik ◽  
D. Mustafa ◽  
E. Vietsch ◽  
C. van Eijck
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Patients ◽  
Cytokine Levels
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