Secondary and cumulative meta-analysis of olanzapine for antiemetic prophylaxis for chemotherapy-induced nausea and vomiting: do we still need to study its effectiveness?

Objective This study was designed to compare the effectiveness of granisetron plus dexamethasone for preventing postoperative nausea and vomiting (PONV) in patients undergoing laparoscopic surgery. Methods We searched the literature in the Cochrane Library, PubMed, EMBASE, and CNKI. Results In total, 11 randomized controlled trials were enrolled in this analysis. The meta-analysis showed that granisetron in combination with dexamethasone was significantly more effective than granisetron alone in preventing PONV in patients undergoing laparoscopy surgery. No significant differences in adverse reactions (dizziness and headache) were found in association with dexamethasone. Conclusion Granisetron in combination with dexamethasone was significantly more effective than granisetron alone in preventing PONV in patients undergoing laparoscopic surgery, with no difference in adverse reactions between the two groups. Granisetron alone or granisetron plus dexamethasone can be used to prevent PONV in patients undergoing laparoscopic surgery.

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Should palonosetron be a preferred 5-HT3 receptor antagonist for chemotherapy-induced nausea and vomiting? An updated systematic review and meta-analysis

Supportive Care in Cancer ◽

10.1007/s00520-018-4237-7 ◽

2018 ◽

Vol 26 (8) ◽

pp. 2519-2549 ◽

Cited By ~ 5

Author(s):

Ronald Chow ◽

David G. Warr ◽

Rudolph M. Navari ◽

May Tsao ◽

Marko Popovic ◽

...

Keyword(s):

Systematic Review ◽

Receptor Antagonist ◽

Meta Analysis ◽

Nausea And Vomiting

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Intravenous dexmedetomidine during spinal anaesthesia for caesarean section: A meta-analysis of randomized trials

Journal of International Medical Research ◽

10.1177/0300060517708945 ◽

2017 ◽

Vol 45 (3) ◽

pp. 924-932 ◽

Cited By ~ 2

Author(s):

Zeqing Bao ◽

Chengmao Zhou ◽

Xianxue Wang ◽

Yu Zhu

Keyword(s):

Caesarean Section ◽

Spinal Anaesthesia ◽

Randomized Trials ◽

Meta Analysis ◽

Relevant Literature ◽

Nausea And Vomiting ◽

Cochrane Library ◽

Control Group ◽

Efficacy And Safety ◽

The Cochrane Library

Objective To evaluate the efficacy and safety of spinal anaesthesia using dexmedetomidine for caesarean section. Methods PubMed, The Cochrane Library, and CNKI were searched for relevant literature. Results The incidence of nausea and vomiting in the dexmedetomidine group was significantly lower than that in the control group (OR = 0.21, 95% CI: 0.12–0.35, P < 0.00001). No difference was found in the incidence of pruritus between the two groups (OR = 1.21, 95% CI: 0.36–4.09, P = 0.76).The dexmedetomidine group had a higher incidence of bradycardia than did the control group (OR = 2.20, 95% CI: 1.02–4.77, P = 0.05). The incidence of shivering in the dexmedetomidine group was significantly lower than that in the control group (OR = 0.20, 95% CI: 0.13–0.32, P < 0.00001). The incidence of hypotension was not different between the two groups (OR = 0.88, 95% CI: 0.49–1.56, P = 0.65). Conclusion Dexmedetomidine can decrease the incidence of nausea, vomiting, bradycardia, and shivering with spinal anaesthesia during caesarean section.

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Peer review report 1 on “Dexamethasone combined with other antiemetics versus single antiemetics for prevention of postoperative nausea and vomiting after laparoscopic cholecystectomy: An updated systematic review and meta-analysis”

International Journal of Surgery ◽

10.1016/j.ijsu.2016.12.021 ◽

2017 ◽

Vol 37 ◽

pp. 17

Keyword(s):

Systematic Review ◽

Laparoscopic Cholecystectomy ◽

Peer Review ◽

Postoperative Nausea ◽

Meta Analysis ◽

Postoperative Nausea And Vomiting ◽

Nausea And Vomiting

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Chemotherapy-induced nausea and vomiting (CINV) with carboplatin plus pemetrexed or carboplatin plus paclitaxel in patients with lung cancer: a propensity score-matched analysis

BMC Cancer ◽

10.1186/s12885-021-07802-y ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Toshinobu Hayashi ◽

Mototsugu Shimokawa ◽

Koichi Matsuo ◽

Hirotoshi Iihara ◽

Kei Kawada ◽

...

Keyword(s):

Risk Factors ◽

Lung Cancer ◽

Propensity Score ◽

Nausea And Vomiting ◽

Lung Cancer Patients ◽

Pooled Data ◽

Female Sex ◽

Antiemetic Prophylaxis ◽

Delayed Nausea ◽

Independent Risk Factors

Abstract Background Patients with lung cancer who are treated with carboplatin-based chemotherapy regimens often experience chemotherapy-induced nausea and vomiting (CINV). However, knowledge on the effect of regimen and cofactors on the risk of CINV is limited. This study aimed to analyze and compare the incidence of CINV between lung cancer patients undergoing carboplatin plus pemetrexed (CBDCA+PEM) and those undergoing carboplatin plus paclitaxel (CBDCA+PTX) chemotherapy. Methods Pooled data of 240 patients from two prospective observational studies were compared using propensity score matching. Separate multivariate logistic regression analyses were used to identify risk factors for nausea and vomiting following chemotherapy. Results Delayed nausea was significantly more common in patients treated with CBDCA+PEM than in those treated with CBDCA+PTX (51.1% vs. 36.2%, P = 0.04), but the incidence of vomiting did not significantly differ between the two groups (23.4% vs. 14.9%, P = 0.14). The occurrence of CINV peaked on day 4 in the CBDCA+PTX group and on day 5 in the CBDCA+PEM group. Multivariate analysis showed that female sex, younger age, and CBDCA+PEM regimen were independent risk factors for delayed nausea, while female sex was an independent risk factor for delayed vomiting. Conclusions The CBDCA + PEM regimen has a higher risk of causing delayed nausea than the CBDCA + PTX regimen, and aggressive antiemetic prophylaxis should be offered to patients treated with CBDCA + PEM.

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