scholarly journals Evolving treatment options for valve and aortic disease with bicuspid aortic valve

2017 ◽  
Vol 5 (16) ◽  
pp. 333-333
Author(s):  
Nicholas S. Burris ◽  
Michael D. Hope
Keyword(s):  
Aortic Valve ◽  
Bicuspid Aortic Valve ◽  
Treatment Options ◽  
Aortic Disease

Abstract 102: Granular Media Calcinosis in the Aortic Wall of Patients With Bicuspid and Tricuspid Aortic Valves

2014 ◽  
Vol 34 (suppl_1) ◽  
Author(s):  
Sandy von Salisch ◽  
Josephina Haunschild ◽  
Martin Misfeld ◽  
Michael A Borger ◽  
Stefan Dhein ◽  
...  
Keyword(s):  
Aortic Valve ◽  
Bicuspid Aortic Valve ◽  
Granular Media ◽  
Aortic Wall ◽  
Aortic Disease ◽  
Dissecting Aneurysm ◽  
Media Thickness ◽  
Significant Difference ◽  
The Media ◽  
Aneurysm Dissection

Background: Bicuspid aortic valve is the most frequent congenital cardiac abnormality and associated with proximal aortic disease (i.e. aneurysm, dissection or rupture). Granular media calcinosis(GMC)--suggested to increase stiffness and play a pathogenetic role in dissecting aneurysm--has not yet been quantified in BAV. Methods: Specimen of the proximal aortic wall from 76 patients--32 with tricuspid (TAV) and 44 with bicuspid aortic valve (BAV)--were obtained during surgery to quantify media thickness and GMC by von Kossa staining (panel C), comparing the convexity (Cvx) and concavity (Ccv) in BAV vs. TAV. Results: Interlamellar GMC affected the most central layers of the media and those adjacent to the outer adventitia with a doubling within both--the Cvx and Ccv--of pts with BAV compared to patients with TAV (13.3±9.6 vs. 6.6±7.4 and 12.8±10.8 vs. 6.4±7.1; p<0.05, panel A) was seen, but neither a difference in calcification between the Ccx and the Ccv side within the BAV nor the TAV group. No association between age and calcification grade , neither in the Cvx nor the Ccv (r=0.132, p=0.218 and 0.103, p=0.341) was seen. There was a significant difference in the total media thickness between BAV and TAV at the Cvx (867±162μm vs . 993±158μm; p<0.05) and the Ccv (1005 ± 236 vs 1223 ± 217μm; p<0.05, panel B). Independent of aortic valve morphology, the Cvx was thinner than the Ccv side (TAV: 993 ± 158 vs.1223 ± 217μm; p<0.001; BAV: 869 ± 162 vs.1005 ± 236μm; p<0.05, panel B). Conclusion: BAVs had significantly thinner media and twice as much GMC than their tricuspid peers possibly associated with the loosening of the bond between the elastic lamellae causing a decrease in elasticity possibly explaining a higher risk for dissection and rupture.

scholarly journals Current and Future Aspects of Multimodal Imaging, Diagnostic, and Treatment Strategies in Bicuspid Aortic Valve and Associated Aortopathies

2020 ◽  
Vol 9 (3) ◽  
pp. 662
Author(s):  
Shazia Afzal ◽  
Kerstin Piayda ◽  
Oliver Maier ◽  
Shouheng Goh ◽  
Katharina Hellhammer ◽  
...  
Keyword(s):  
Aortic Valve ◽  
Aortic Valve Replacement ◽  
Valve Replacement ◽  
Bicuspid Aortic Valve ◽  
Treatment Options ◽  
Treatment Strategies ◽  
Fusion Imaging ◽  
Surgical Aortic Valve Replacement ◽  
Transcatheter Aortic Valve ◽  
Depth Analysis

Bicuspid aortic valve (BAV) is the most frequent congenital cardiac abnormality leading to premature aortic valve apparatus dysfunction and is often associated with aortopathy. Therefore, current guidelines recommend a surgical aortic valve replacement (SAVR), even if many patients are deemed inoperable owing to their comorbidities and require alternatives such as transcatheter aortic valve replacement (TAVR). However, BAV variations remain challenging for procedural success. Therefore, the latest development in different imaging modalities (echocardiography, multislice-computertomographie, cardiovascular magnetic resonance) allows in-depth analysis for preprocedural risk stratification, follow up, and patient selection. Furthermore, we shed light on the latest developments in pre- and periprocedural fusion imaging as well as on current and future treatment options.

scholarly journals Bicuspid aortic valve and aortic disease. The role of family screening

2013 ◽  
Vol 34 (suppl 1) ◽  
pp. P4757-P4757
Author(s):  
A. Carro ◽  
G. Teixido ◽  
M. Sanz ◽  
V. Galuppo ◽  
L. Galian ◽  
...  
Keyword(s):  
Aortic Valve ◽  
Bicuspid Aortic Valve ◽  
Aortic Disease ◽  
Family Screening

scholarly journals MRI hemodynamic markers of progressive bicuspid aortic valve-related aortic disease

2013 ◽  
Vol 40 (1) ◽  
pp. 140-145 ◽  
Author(s):  
Michael D. Hope ◽  
Monica Sigovan ◽  
S. Jarrett Wrenn ◽  
David Saloner ◽  
Petter Dyverfeldt
Keyword(s):  
Aortic Valve ◽  
Bicuspid Aortic Valve ◽  
Aortic Disease

scholarly journals Aortic arch tortuosity, a novel biomarker for thoracic aortic disease, is increased in adults with bicuspid aortic valve

2019 ◽  
Vol 284 ◽  
pp. 84-89 ◽  
Author(s):  
Bader Aldeen Alhafez ◽  
Van Thi Thanh Truong ◽  
Daniel Ocazionez ◽  
Sahand Sohrabi ◽  
Harleen Sandhu ◽  
...  
Keyword(s):  
Aortic Valve ◽  
Aortic Arch ◽  
Bicuspid Aortic Valve ◽  
Aortic Disease ◽  
Thoracic Aortic Disease

Circulating microRNAs vs. aortic diameter in bicuspid aortic valve aortopathy

2020 ◽  
pp. 021849232092723
Author(s):  
Shiho Naito ◽  
Johannes Petersen ◽  
Tatiana Sequeira-Gross ◽  
Tanja Zeller ◽  
Hermann Reichenspurner ◽  
...  
Keyword(s):  
Aortic Valve ◽  
Risk Stratification ◽  
Bicuspid Aortic Valve ◽  
Treatment Guidelines ◽  
Aortic Disease ◽  
Current Evidence ◽  
Diagnostic Tools ◽  
Circulating Micrornas ◽  
Prediction Tools ◽  
Improve Risk Stratification

There is growing clinical need and interest to implement novel risk prediction tools in bicuspid aortic valve-associated proximal aortic disease, so-called bicuspid aortic valve aortopathy. Inherent limitations of the diameter-based risk stratification for adverse aortic events in bicuspid aortic valve aortopathy patients have recently been recognized. Therefore, alternative diagnostic tools and subsequent adjustments in the treatment guidelines are urgently needed. Herein, we summarize the current evidence on recent diagnostic developments to improve risk stratification in bicuspid aortic valve aortopathy, including circulating microRNAs as biomarkers to predict the progression of aortic disease.

scholarly journals Bicuspid aortic valve associated aortopathy: a genetic disease

2015 ◽  
Vol 4 (1) ◽  
Author(s):  
Gibran Minero ◽  
Simon C. Body
Keyword(s):  
Aortic Valve ◽  
Bicuspid Aortic Valve ◽  
Genetic Disease ◽  
Genetic Variant ◽  
Aortic Disease ◽  
Common Mechanism ◽  
Thoracic Aortic Disease ◽  
Strength Of Evidence ◽  
Flow Through ◽  
Hemodynamic Alteration

As the most common congenital heart defect, understanding the etiology and progression of aortopathy in bicuspid aortic valve (BAV) is imperative to management of patients with BAV. A reasonable hypothesis, based on the strength of evidence for both genetic and hemodynamic causes of BAV-associated thoracic aortic disease (TAD), is that BAV is caused by genetic variant(s) that also predispose to TAD by a common mechanism; presumably by cell-signaling resulting in an embryologic defect that causes BAV and a postnatal risk of TAD that is accentuated by hemodynamic stress of abnormal flow through the BAV valve. Clinical heterogeneity seen in BAVassociated TAD is likely due to individual genetic variation and the severity of hemodynamic alteration.

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