scholarly journals MGTX extension study longitudinally favors early thymectomy in non-thymomatous young-adult patients with AChR antibody-positive myasthenia gravis

2019 ◽  
Vol 7 (S6) ◽  
pp. S208-S208 ◽  
Tetsuya Akaishi ◽  
Masakatsu Motomura ◽  
Masashi Aoki ◽  
Kimiaki Utsugisawa
Barbara Altieri ◽  
Roberta Modica ◽  
Filomena Bottiglieri ◽  
Cicco Federica de ◽  
Antongiulio Faggiano ◽  

2020 ◽  
Vol 22 (Supplement_3) ◽  
pp. iii329-iii329
Minako Sugiyama ◽  
Takayuki Hashimoto ◽  
Takashi Mori ◽  
Kazuya Hara ◽  
Yukayo Terashita ◽  

Abstract BACKGROUND To reduce treatment-related adverse events in pediatric and young-adult patients with brain tumors, proton beam radiotherapy (PBT) has recently been performed instead of conventional X-ray radiotherapy. However, whether PBT is as effective as X-ray radiotherapy has not been sufficiently investigated, especially in patients receiving whole-ventricular irradiation. METHODS We report a retrospective observation of 15 patients with intracranial germ cell tumors (GCT), who received PBT at our institution from April 2014 to September 2019. We evaluated their clinical course, short-term adverse events, and prognosis. RESULTS/ CONCLUSION Fifteen patients (9 males and 6 females; median age 13 years) who received PBT following induction chemotherapy were analyzed. Nine patients received 23.4–27.0 GyE of whole-ventricular irradiation due to GCT in the pituitary gland, pineal body, or hypothalamic area. Three patients received 23.4 GyE of whole-brain irradiation: one of them had boost irradiation for basal ganglia. Three patients received 30.6 GyE of craniospinal irradiation (CSI). Six of the 15 patients experienced nausea (grade 2, according to the CTCAE version 4.0). Four patients, including two who received CSI, showed myelosuppression: decrease in white blood cell count, lymphocyte cell count, and neutrophil count (grade 3). No other severe short-term adverse events of >grade 2 was observed in any of the patients. At a median follow-up of 21 months (2-62 months) after irradiation. all patients are alive without recurrence. Our results may be encouraging and further investigations with a larger scale is warranted.

Christabel K. Cheung ◽  
Patricia W. Nishimoto ◽  
Thuli Katerere-Virima ◽  
Laura E. Helbling ◽  
Bria N. Thomas ◽  

2021 ◽  
Kjersti J. Ø. Fløtten ◽  
Ana Isabel Fernandes Guerreiro ◽  
Ilaria Simonelli ◽  
Anne Lee Solevåg ◽  
Isabelle Aujoulat

2014 ◽  
Vol 23 (3) ◽  
pp. e221-e227 ◽  
Rosaria Renna ◽  
Fabio Pilato ◽  
Paolo Profice ◽  
Giacomo Della Marca ◽  
Aldobrando Broccolini ◽  

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