Abstract
Background: Pulmonary pleomorphic carcinoma (PPC) is a rare tumor, and it usually has an aggressive clinical course and poor prognosis. We aim to analyze the clinicopathological features, management and prognostic factors of pulmonary pleomorphic carcinoma. Patients and methods: Using the Surveillance, Epidemiology, and End Results (SEER) database, we identified 310 patients of pulmonary pleomorphic carcinoma from 2004 to 2014 including clinicopathological characteristics, treatment modalities and outcome data.Results: The mean age of all PPC patients was 66 years and 59.4% of the patients were male. Most patients (79.4%) were white people, 51.6% were found in the right lung, and lesions were mostly observed in upper lobe (57.7%). The median overall survival was 12 months and overall 1-, 3- and 5- year survival rate was 42.5%, 28.6%, 24.1%. In Kaplan-Meier analysis, tumor primary site, lymph node metastases, distant metastases, summary stage, chemotherapy and surgery were associated with overall survival. Patients with surgery or chemotherapy have a better OS for patients with PPC. However, we found that radiotherapy did not significantly improve OS Multivariate Cox analysis revealed that SEER summary stage, distant metastases, surgery and chemotherapy were found to be independently associated with the OS.Conclusions: PPC mostly occurred in white people, with a median age of 66 years, and men were more susceptible to this disease. The SEER summary stage, distant metastases, surgery and chemotherapy were independently associated with prognosis.
Clinicopathological characteristics and prognosis of pulmonary pleomorphic carcinoma: a population-based retrospective study using SEER data