The predictive value of galectin-1 and vascular mimicry in the prognostic evaluation of patients with rectal cancer

Carcinoembryonic antigen and some liver function tests (alkaline phosphatase, gamma-glutamyl-transpeptidase, lactic dehydrogenase and cholinesterase) were evaluated in patients with primary colorectal cancer in order to define their role in the pre-operative detection of liver metastases.The records of 278 consecutive patients admitted to the Istituto Nazionale Tumori of Milan between January 1982 and December 1983 who were suffering from primary invasive colo-rectal cancer and who underwent laparotomy were retrospectively analyzed.At laparotomy, liver metastases were found in 38 pts (13.7%). Considering single tests, CEA was the most sensitive (71%); no single test was found to be reliably predictive, when the result was abnormal. On the contrary, the normal value of each test was associated with a good prediction.When we considered all the five tests together in the single patient their predictive value, when abnormal, proved to be quite good only if four or five results were abnormal. On the other hand, liver metastases in the presence of all normal tests were found only in two patients, so giving a negative predictive value of about 97%.So we conclude that, in the lack of an infallable imaging technique for liver evaluation, in the presence of all normal tests any other investigation on the liver could be avoided. However, when liver tests are pathologic, some other imaging technique should be performed in order to supply the surgeon with information about the extent and the spread of the metastases.

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The potential predictive value of tumor budding for neoadjuvant chemoradiotherapy response in locally advanced rectal cancer

Strahlentherapie und Onkologie ◽

10.1007/s00066-018-1340-0 ◽

2018 ◽

Vol 194 (11) ◽

pp. 991-1006 ◽

Cited By ~ 7

Author(s):

Tarkan Jäger ◽

Daniel Neureiter ◽

Mohammad Fallaha ◽

Philipp Schredl ◽

Tobias Kiesslich ◽

...

Keyword(s):

Rectal Cancer ◽

Predictive Value ◽

Locally Advanced ◽

Neoadjuvant Chemoradiotherapy ◽

Advanced Rectal Cancer ◽

Locally Advanced Rectal Cancer ◽

Tumor Budding

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Predictive value of carcinoembryonic antigen and carbohydrate antigen 19-9 related to downstaging to stage 0–I after neoadjuvant chemoradiotherapy in locally advanced rectal cancer

Cancer Management and Research ◽

10.2147/cmar.s166417 ◽

2018 ◽

Vol Volume 10 ◽

pp. 3101-3108 ◽

Cited By ~ 3

Author(s):

Jianyuan Song ◽

Xiaoxue Huang ◽

Zhuhong Chen ◽

Mingqiu Chen ◽

Qingliang Lin ◽

...

Keyword(s):

Rectal Cancer ◽

Carcinoembryonic Antigen ◽

Predictive Value ◽

Locally Advanced ◽

Neoadjuvant Chemoradiotherapy ◽

Advanced Rectal Cancer ◽

Locally Advanced Rectal Cancer ◽

Carbohydrate Antigen

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The Role of VEGFA, COX2, HUR and CUGBP2 in Predicting the Response to Neoadjuvant Therapy in Rectal Cancer Patients

Medicina ◽

10.3390/medicina56040192 ◽

2020 ◽

Vol 56 (4) ◽

pp. 192

Author(s):

Henrikas Pauzas ◽

Ugne Gyvyte ◽

Tadas Latkauskas ◽

Laura Kairevice ◽

Paulius Lizdenis ◽

...

Keyword(s):

Gene Expression ◽

Rectal Cancer ◽

Neoadjuvant Therapy ◽

Predictive Value ◽

Post Treatment ◽

Treatment Changes ◽

Pre Treatment ◽

Cox2 Expression ◽

Vegfa Gene

Background and objectives: The effectiveness of neoadjuvant therapy, which is commonly used for stage II-III rectal cancer (RC) treatment, is limited. Genes associated with the pathogenesis of RC could determine response to this treatment. Therefore, the aim of this study was to investigate the potential predictive value of VEGFA, COX2, HUR and CUGBP2 genes and the associations between post-treatment changes in gene expression and the efficacy of neoadjuvant therapy. Materials and Methods: Biopsies from RC and healthy rectal tissue of 28 RC patients were collected before neoadjuvant therapy and 6-8 weeks after neoadjuvant therapy. The expression levels of VEGFA, COX2, HUR, CUGBP2 genes were evaluated using a quantitative real-time polymerase chain reaction. Results: The results reveal a significantly higher expression of VEGFA, COX2 and HUR mRNA in RC tissue compared to healthy rectal tissue (p < 0.05), and elevated VEGFA gene expression in pre-treatment tissues was associated with a better response to neoadjuvant therapy based on T-stage downstaging (p < 0.05). The expression of VEGFA, HUR and CUGBP2 genes significantly decreased after neoadjuvant therapy (p < 0.05). Responders to treatment demonstrated a significantly stronger decrease of VEGFA and COX2 expression after neoadjuvant therapy than non-responders (p < 0.05). Conclusions: The findings of this study suggest that the pre-treatment VEGFA gene expression might have predictive value for the response to neoadjuvant therapy, while the post-treatment decrease in VEGFA and COX2 gene expression could indicate the effectiveness of neoadjuvant therapy in RC patients.

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Population-based assessment of the National Comprehensive Cancer Network recommendations for baseline imaging of rectal cancer

Journal of Comparative Effectiveness Research ◽

10.2217/cer-2019-0043 ◽

2019 ◽

Vol 8 (14) ◽

pp. 1167-1172

Author(s):

Omar Abdel-Rahman ◽

Winson Y Cheung

Keyword(s):

Rectal Cancer ◽

Liver Metastases ◽

Cancer Patients ◽

Predictive Value ◽

Lung Metastases ◽

Early Stage ◽

Abdominal Imaging ◽

Performance Characteristics ◽

Seer Database ◽

Routine Imaging

Aim: To examine the performance characteristics of alternative criteria for baseline staging, in a cohort of contemporary rectal cancer patients from the Surveillance, Epidemiology and End Results (SEER) database. Methods: The SEER database (2010–2015) was accessed and patients with rectal cancer plus complete information on clinical T and N stages as well as metastatic sites were evaluated. We examined various performance characteristics of baseline imaging, including specificity, sensitivity, number needed to investigate (NNI), positive predictive value (PPV), negative predictive value and accuracy. Results: A total of 15,836 rectal cancer patients were included. Based on current guidelines that suggest cross-sectional chest and abdominal imaging for all cases of invasive rectal cancer, these recommendations would yield a PPV of 11.9% for the detection of liver metastases and 6.2% for the detection of lung metastases. This would translate to an NNI of 8.4 for liver metastases and an NNI of 16.1 for lung metastases. When patients with T1N0 were excluded from routine imaging, this resulted in a PPV of 6.4% and an NNI of 15.6 to identify one case of lung metastasis. Likewise, this resulted in a PPV of 12.3% and an NNI of 8.0 to detect one case of liver metastasis. Similarly, when patients with either T1N0 or T2N0 were excluded from routine imaging, the PPV and NNI for lung metastases improved to 6.6% and 15.1, respectively, and the PPV and NNI for liver metastases improved to 12.6 and 7.9%, respectively. Conclusion: Our study suggests that the specificity of the current imaging approach for rectal cancer staging is limited and that the omission of chest and abdominal imaging among selected early stage asymptomatic cases may be reasonable to consider.

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