scholarly journals Complete response after radiation-assisted immunotherapy for metastatic urothelial carcinoma: a case report and literature review

2020 ◽  
Vol 4 ◽  
pp. 23-23
Author(s):  
Cheng-Sheng Liu ◽  
Chien-Jui Cheng ◽  
Yun-Ru Liu ◽  
Shauh-Der Yeh ◽  
Shiu-Chen Jeng ◽  
...  
Keyword(s):  
Case Report ◽  
Literature Review ◽  
Urothelial Carcinoma ◽  
Complete Response ◽  
Metastatic Urothelial Carcinoma

Fibroblast Growth Factor Receptor Inhibitor–Associated Multifocal Serous Retinal Detachments: A Case Report

2021 ◽  
pp. 247412642110136
Author(s):  
Diana H. Kim ◽  
Tian Xia ◽  
Peter Bracha ◽  
Brian L. VanderBeek
Keyword(s):  
Case Report ◽  
Growth Factor ◽  
Urothelial Carcinoma ◽  
Fibroblast Growth Factor ◽  
Fibroblast Growth Factor Receptor ◽  
Growth Factor Receptor ◽  
Fibroblast Growth ◽  
Metastatic Urothelial Carcinoma ◽  
Optical Coherence Tomography Imaging ◽  
Receptor Inhibitor

Purpose: This report aims to describe a case of bilateral, multifocal neurosensory retinal detachments that developed during erdafitinib therapy for metastatic urothelial carcinoma. Methods: A case report with color fundus imaging and spectral-domain optical coherence tomography imaging is presented. Results: A 50-year-old man with metastatic urothelial carcinoma had an unremarkable baseline ophthalmic examination prior to starting erdafitinib. At 3-month follow up, an examination revealed bilateral, multifocal retinal detachments. Because the patient was asymptomatic and erdafitinib was the only drug to which his tumor had responded, he was kept on the medication with close ophthalmic monitoring. Conclusions: Erdafitinib, a fibroblast growth factor receptor inhibitor, can cause bilateral, multifocal retinal detachments. Continuation of erdafitinib may be considered in patients without significant visual impairment when the overall benefit of the medication appears to outweigh the risks.

scholarly journals Bladder cancer. A retrospective analysis of the use of vinfluvin in real clinical practice

2021 ◽  
Vol 8 (2) ◽  
pp. 34-42
Author(s):  
A. S. Zhabina ◽  
A. I. Novikov ◽  
F. V. Moiseenko ◽  
N. M. Volkov ◽  
E. O. Stepanova ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Clinical Practice ◽  
Adverse Events ◽  
Medical Care ◽  
Urothelial Carcinoma ◽  
Response Duration ◽  
Complete Response ◽  
Metastatic Urothelial Carcinoma ◽  
Real Practice ◽  
Real Clinical Practice

Purpose of the study. There is the generalized analysis of administration of vinflunine in real clinical practice in St.Petersburg Clinical Scientific and Practical Center of Specialized medical Care (oncological).Materials and methods. This analysis gathered 27 patients with urothelial carcinoma treated using this medicine in St.Petersburg Clinical Scientific and Practical Center of Specialized medical Care (oncological). We assessed efficacy, safety profile of vinflunine in this subset of patients.Results. Clinical efficacy of vinflunine (complete response + partial response + stable disease) was 51,86 %, one patient demonstrated complete response. Median of response duration accounts for 3,4 months. Adverse events were observed in 28,4 %, most of them were 1-2 grades. 2 patients stopped therapy due to adverse events.Conclusion. In our analysis vinflunine was more effective than in randomized clinical trial and other studies from real practice in Europe. Thus, confirm expediency to administer of vinflunine for metastatic urothelial carcinoma.

scholarly journals Synchronous metastatic seminoma and primary retroperitoneal ganglioneuroma: case report and literature review

2013 ◽  
Vol 5 (6) ◽  
pp. 109
Author(s):  
Jorg Michels ◽  
Nicholas Van der Westhuizen ◽  
Alison Ross
Keyword(s):  
Case Report ◽  
Literature Review ◽  
Testicular Cancer ◽  
Germ Cell ◽  
Complete Response ◽  
Testicular Seminoma ◽  
Rare Tumours ◽  
Primary Retroperitoneal ◽  
Common Malignancy

Testicular cancer is the most common malignancy in young menwith seminomas comprising almost half of all germ cell tumours.Benign ganglioneuromas are rare tumours derived from the sympatheticnervous system. They usually occur in aldolescents andyoung adults and are predominantly located in the mediastinumand retroperitoneum. We report a case of a patient with synchronousmetastatic testicular seminoma with retroperitoneal lymphnode involvement and a benign retroperitoneal ganglioneuroma(RGN) which caused diagnostic and management challenges. Thepatient had a complete response following combination chemotherapyfor his seminoma and subsequently underwent completeresection of his ganglioneuroma.

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