Evaluation of Probability of Plague Epizooties Detection at the Minimal Level of Epizootic Process Intensity Measured Using Its Modeling

Problems of Particularly Dangerous Infections ◽

10.21055/0370-1069-2011-2(108)-19-21 ◽

2011 ◽

pp. 19-21 ◽

Cited By ~ 1

Author(s):

V. M. Dubyanskii

Keyword(s):

Minimal Level ◽

Low Level ◽

Epizootic Process ◽

Rhombomys Opimus

Using model of plague epizootic process in great gerbils (Rhombomys opimus) settlements, authors showed that plague epizooty could develop at low level of epizootic contact. In this case the size of epizootic site and the number of infected colonies were expected to be insufficient to detect epizooty by standard epizootiologic examination.

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Minimum of Great Gerbil Colonies ( Rhombomys opimus Liht., 1823., Rodendtia, Crecetidae) Necessary for Plague Epizooty Development in the Model

Problems of Particularly Dangerous Infections ◽

10.21055/0370-1069-2013-2-19-21 ◽

2013 ◽

pp. 19-21

Author(s):

V. M. Dubyansky

Keyword(s):

Computer Model ◽

Process Development ◽

Minimum Threshold ◽

Great Gerbil ◽

Epizootic Process ◽

Rhombomys Opimus

It is commonly known that under gerbil population depression habitable colonies are preserved as groups with varying number of colonies. In this connection, objectives of the study have turned out to be determination of minimum threshold number as regards habitable colonies where plague microbe circulation takes place. With the help of the computer model for plague epizootic process development determined is the fact that plague epizooty can last for a long while within the group of 25 habitable great gerbil colonies under certain conditions. This measure is reasonably close to the known factual evidence concerning a number and distribution of colonies at the time of major population depression. Therewith, one can conclude that plague microbe circulation can take place even in the course of major great gerbil population depression.

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A computer model of plague epizootic process in the great gerbil (Rhombomys opimus) settlements: Description and test for adequacy

Biology Bulletin ◽

10.1134/s1062359010070095 ◽

2010 ◽

Vol 37 (7) ◽

pp. 733-740

Author(s):

V. M. Dubyanskiy ◽

L. A. Burdelov

Keyword(s):

Computer Model ◽

Great Gerbil ◽

Epizootic Process ◽

Rhombomys Opimus

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Tryptophan-Niacin Metabolism in Rat with Puromycin Aminonucleoside-Induced Nephrosis

International Journal for Vitamin and Nutrition Research ◽

10.1024/0300-9831.76.1.28 ◽

2006 ◽

Vol 76 (1) ◽

pp. 28-33 ◽

Cited By ~ 7

Author(s):

Yukari Egashira ◽

Shin Nagaki ◽

Hiroo Sanada

Keyword(s):

Body Weight ◽

Urinary Excretion ◽

Enzyme Activities ◽

Treated Group ◽

Control Group ◽

Puromycin Aminonucleoside ◽

Low Level ◽

Key Enzyme

We investigated the change of tryptophan-niacin metabolism in rats with puromycin aminonucleoside PAN-induced nephrosis, the mechanisms responsible for their change of urinary excretion of nicotinamide and its metabolites, and the role of the kidney in tryptophan-niacin conversion. PAN-treated rats were intraperitoneally injected once with a 1.0% (w/v) solution of PAN at a dose of 100 mg/kg body weight. The collection of 24-hour urine was conducted 8 days after PAN injection. Daily urinary excretion of nicotinamide and its metabolites, liver and blood NAD, and key enzyme activities of tryptophan-niacin metabolism were determined. In PAN-treated rats, the sum of urinary excretion of nicotinamide and its metabolites was significantly lower compared with controls. The kidneyα-amino-β-carboxymuconate-ε-semialdehyde decarboxylase (ACMSD) activity in the PAN-treated group was significantly decreased by 50%, compared with the control group. Although kidney ACMSD activity was reduced, the conversion of tryptophan to niacin tended to be lower in the PAN-treated rats. A decrease in urinary excretion of niacin and the conversion of tryptophan to niacin in nephrotic rats may contribute to a low level of blood tryptophan. The role of kidney ACMSD activity may be minimal concerning tryptophan-niacin conversion under this experimental condition.

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