scholarly journals Structure and Functional Role of Bacterial CRISPR System

2011 ◽  
pp. 49-52 ◽  
Author(s):  
A. V. Shashkova ◽  
A. A. Goryaev ◽  
N. I. Smirnova
Keyword(s):  
Mechanism Of Action ◽  
Molecular Typing ◽  
Genetic Information ◽  
Functional Role ◽  
Review Of Literature ◽  
Crispr System ◽  
Structural Peculiarities ◽  
Putative Mechanism

Presented is the review of literature data on the recently discovered system of Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR), which takes part in the defense against penetration of alien genetic information in prokaryotes. CRISPR structural peculiarities and functions, and putative mechanism of action are described. Also presented are data on the availability of this system in particularly dangerous infections agents and on the possibility of its application for molecular typing.

MicroRNA: mIR-ly regulators of DNMT?

Blood ◽  
2009 ◽  
Vol 113 (25) ◽  
pp. 6269-6270 ◽  
Author(s):  
Elizabeth A. Griffiths ◽  
Steven D. Gore
Keyword(s):  
Mechanism Of Action ◽  
Functional Role ◽  
Present Evidence ◽  
Pharmacologically Active ◽  
Insight Into

Abstract In this issue of Blood, Garzon and colleagues present evidence for a functional role of miR 29b in controlling DNMT levels in leukemia. Their work may provide insight into the mechanism of action of the azanucleotides and could potentially offer the first pharmacologically active miRNA.

scholarly journals Morphological Changes of Ureteropelvic Junction (UPJ) in Case of Congenital Hydronephrosis – Review of Literature

2013 ◽  
Vol 13 (2) ◽  
pp. 72-75
Author(s):  
Daila Pugacevska ◽  
Valerija Groma ◽  
Aigars Petersons ◽  
Ivars Melderis ◽  
Ainars Gilis
Keyword(s):  
Interstitial Cells Of Cajal ◽  
Structural Changes ◽  
Morphological Changes ◽  
Muscle Layer ◽  
Review Of Literature ◽  
Common Cause ◽  
Congenital Hydronephrosis ◽  
Structural Peculiarities ◽  
Cells Of Cajal

Abstract Congenital hydronephrosis is the most common cause of antenatally detected hydronephrotic transformation. Obstruction of UPJ can be intrinsic or extrinsic. Most cases of intrinsic stenosis do not require any treatment as it disappears during growth of a child. It is considered that in these cases wave of peristalsis appears again in aperistaltic UPJ. The cells responsible for peristalsis wave impulses, mechanisms of conduction of these impulses and regulation of them are not well recognized. Similarly, it is not clear why functional UPJ stenosis appears and disappears untreated in most cases. Researchers believe that all these processes are associated with the structural peculiarities of UPJ - changes in urothelium, muscle layer and innervation. The role of interstitial cells of Cajal (ICCs), important contributors of the urinary tract physiology, has not been extended to the obstruction of UPJ. Structural changes of UPJ wall are conclusive while choosing the most appropriate method of surgical treatment in newborns with congenital hydronephrosis.

scholarly journals STUDIES ON IMMUNE HUMAN HEMOLYSIS

1961 ◽  
Vol 113 (1) ◽  
pp. 193-218 ◽  
Author(s):  
Carl F. Hinz ◽  
Mary E. Picken ◽  
Irwin H. Lepow
Keyword(s):  
Mechanism Of Action ◽  
Human Disease ◽  
Esterase Activity ◽  
Functional Role ◽  
Disease State ◽  
The Other ◽  
Human Model ◽  
Human Complement ◽  
Serum Inhibitor

1. The inactivation, of C'1 blocks the completion of the cold phase of the Donath-Landsteiner reaction; inactivation of the other components of complement does not interfere with the cold phase of the reaction. 2. C'2, C'3, and C'4 are required for the completion of the hemolytic reaction. C'4 reacts in either the cold or warm phase, but C'2 and C'3 must react in the warm phase. 3. Partially purified C'1 or C'1 esterase can be substituted for whole serum in the cold phase, although neither reagent contains any of the other components of complement 4. Partially purified serum inhibitor of C'1 esterase blocks the effect of C'1 esterase in the cold phase, and reverses the effect of complement, C'1 or C'1 esterase when incubated with "activated" cells after the cold phase. 5. C'1 esterase activity can be eluted from "activated" erythrocytes with Na3EDTA. 6. The components of human complement in this human hemolytic reaction act in the order C'1, C'4, C'2, C'3. Ca++ is required for the reaction with C'1, and Mg++ is required for the reaction with C'2. 7. Accordingly, a functional role of C'1 esterase in a human disease state is demonstrated, and a human model is established for the study of the mechanism of action of complement.

Expression and functional role of c-Kit and erbB2 in human hepatoblastoma.

2009 ◽  
Vol 221 (03) ◽  
Author(s):  
B Steiger ◽  
I Leuschner ◽  
D Denkhaus ◽  
D von Schweinitz ◽  
T Pietsch
Keyword(s):  
Functional Role

SOME ASPECTS OF THE FUNCTION OF FSH- AND LH-LIKE HORMONES IN NORMAL AND HYPOPHYSECTOMIZED FEMALE RATS, IN CONNECTION WITH RESERPINE ADMINISTRATION

1965 ◽  
Vol 49 (1) ◽  
pp. 28-38
Author(s):  
M. Grönroos ◽  
E. Mäkinen ◽  
K. Lahtinen ◽  
R. Tirri
Keyword(s):  
Mechanism Of Action ◽  
Biological Effect ◽  
Female Rats ◽  
Histological Picture ◽  
Peripheral Effect ◽  
Pituitary Secretion

ABSTRACT The effect of reserpine on the secretion of FSH and LH was studied as well as the role of the peripheral effect of reserpine after hypophysectomy. The results in the unoperated animals suggest that reserpine inhibits the pituitary secretion of both FSH and LH. Both these hormones combined with reserpine had a very different biological effect than was seen without reserpine. HCG (LH-like) and particularly PMS (FSH-like) hormones combined with reserpine caused definite enlargement of the ovaries. In the hypophysectomized groups, the effect of the PMS and HCG hormones administered together with reserpine or without it was the same with regard to the weight of the ovaries, but not with regard to their histological picture. On the basis of these results, reserpine may be said to have a peripheral effect although the nature of its mechanism of action is difficult to state. Reserpine probably affects the ovaries by inhibiting the follicular cycle and, consequently, the formation of new and more mature follicles.

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