A Molecular Genetic Approach to Uncovering the Differential Functions of Dopamine D2 Receptor Isoforms

2012 ◽  
pp. 181-200 ◽  
Author(s):  
Yanyan Wang ◽  
Toshikuni Sasaoka ◽  
Mai T. Dang
Keyword(s):  
Dopamine D2 Receptor ◽  
Molecular Genetic ◽  
D2 Receptor ◽  
Genetic Approach ◽  
Dopamine D2 ◽  
Receptor Isoforms

scholarly journals Preferential Coupling of Dopamine D2S and D2L Receptor Isoforms with Gi1 and Gi2 Proteins—In Silico Study

2020 ◽  
Vol 21 (2) ◽  
pp. 436 ◽  
Author(s):  
Justyna Żuk ◽  
Damian Bartuzi ◽  
Dariusz Matosiuk ◽  
Agnieszka A. Kaczor
Keyword(s):  
Dopamine D2 Receptor ◽  
D2 Receptor ◽  
Antipsychotic Agents ◽  
Intracellular Loop ◽  
Dopamine D2 ◽  
Receptor Isoforms ◽  
In Silico Study ◽  
Third Intracellular Loop ◽  
G Protein Coupled ◽  
Insight Into

The dopamine D2 receptor belongs to rhodopsin-like G protein-coupled receptors (GPCRs) and it is an important molecular target for the treatment of many disorders, including schizophrenia and Parkinson’s disease. Here, computational methods were used to construct the full models of the dopamine D2 receptor short (D2S) and long (D2L) isoforms (differing with 29 amino acids insertion in the third intracellular loop, ICL3) and to study their coupling with Gi1 and Gi2 proteins. It was found that the D2L isoform preferentially couples with the Gi2 protein and D2S isoform with the Gi1 protein, which is in accordance with experimental data. Our findings give mechanistic insight into the interplay between isoforms of dopamine D2 receptors and Gi proteins subtypes, which is important to understand signaling by these receptors and their mediation by pharmaceuticals, in particular psychotic and antipsychotic agents.

scholarly journals Effects of social defeat stress on dopamine D2 receptor isoforms and proteins involved in intracellular trafficking

2018 ◽  
Vol 14 (1) ◽  
Author(s):  
Vishwanath Vasudev Prabhu ◽  
Thong Ba Nguyen ◽  
Yin Cui ◽  
Young-Eun Oh ◽  
Keon-Hak Lee ◽  
...  
Keyword(s):  
Intracellular Trafficking ◽  
Dopamine D2 Receptor ◽  
D2 Receptor ◽  
Social Defeat ◽  
Social Defeat Stress ◽  
Dopamine D2 ◽  
Receptor Isoforms

The abundance of mRNA for dopamine D2 receptor isoforms in brain tissue from controls and schizophrenics

1994 ◽  
Vol 25 (1-2) ◽  
pp. 173-175 ◽  
Author(s):  
D.A. Roberts ◽  
D. Balderson ◽  
S.M. Pickering-Brown ◽  
J.F.W. Deakin ◽  
F. Owen
Keyword(s):  
Brain Tissue ◽  
Dopamine D2 Receptor ◽  
D2 Receptor ◽  
Dopamine D2 ◽  
Receptor Isoforms

Changes of the mRNAs for two dopamine D2 receptor isoforms in rat brain by haloperidol or methamphetamine treatment

1991 ◽  
Vol 4 (3) ◽  
pp. 284
Author(s):  
I. Sora ◽  
Y. Fujiwara ◽  
H. Tomita ◽  
H. Ishizu ◽  
K. Akiyama ◽  
...  
Keyword(s):  
Rat Brain ◽  
Dopamine D2 Receptor ◽  
D2 Receptor ◽  
Dopamine D2 ◽  
Receptor Isoforms

Molecular Characterization of Dopamine D2 Receptor Isoforms Tagged With Green Fluorescent Protein

2006 ◽  
Vol 34 (1) ◽  
pp. 1-14 ◽  
Author(s):  
Keyvan Sedaghat ◽  
Marie-France Nantel ◽  
Simon Ginsberg ◽  
Véronique Lalonde ◽  
Mario Tiberi
Keyword(s):  
Green Fluorescent Protein ◽  
Molecular Characterization ◽  
Fluorescent Protein ◽  
Dopamine D2 Receptor ◽  
D2 Receptor ◽  
Dopamine D2 ◽  
Receptor Isoforms ◽  
Green Fluorescent

Differential desensitization of dopamine D2 receptor isoforms by protein kinase C: The importance of receptor phosphorylation and pseudosubstrate sites

2007 ◽  
Vol 577 (1-3) ◽  
pp. 44-53 ◽  
Author(s):  
Stephen J. Morris ◽  
Irit Itzhaki Van-Ham ◽  
Mireille Daigle ◽  
Liliane Robillard ◽  
Naghmeh Sajedi ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Dopamine D2 Receptor ◽  
D2 Receptor ◽  
Receptor Phosphorylation ◽  
Dopamine D2 ◽  
Kinase C ◽  
Receptor Isoforms

scholarly journals Dopamine D2-Receptor Isoforms Expressed in AtT20 Cells Inhibit Q-Type High-Voltage-Activated Ca2+ Channels via a Membrane-Delimited Pathway

1999 ◽  
Vol 72 (2) ◽  
pp. 479-490 ◽  
Author(s):  
Shannyn E. Wolfe ◽  
Daniel E. Howard ◽  
John A. Schetz ◽  
Caroline J. Cheng ◽  
Robert Webber ◽  
...  
Keyword(s):  
High Voltage ◽  
Dopamine D2 Receptor ◽  
D2 Receptor ◽  
Dopamine D2 ◽  
Receptor Isoforms ◽  
Ca2 Channels
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