Titanium Particles Stimulate Bone Resorption by Inducing Differentiation of Murine Osteoclasts

2001 ◽  
Vol 83 (4) ◽  
pp. 501-508 ◽  
Author(s):  
Yanming Bi ◽  
R. Renee Van De Motter ◽  
Ashraf A. Ragab ◽  
Victor M. Goldberg ◽  
James M. Anderson ◽  
...  
Keyword(s):  
Bone Resorption ◽  
Stimulate Bone Resorption

Actions of palytoxin on Na+ and Ca2+ homeostasis in human osteoblast-like Saos-2 cells

1995 ◽  
Vol 269 (3) ◽  
pp. C582-C589 ◽  
Author(s):  
J. J. Monroe ◽  
A. H. Tashjian
Keyword(s):  
Plasma Membrane ◽  
Bone Resorption ◽  
Organ Culture ◽  
Active Agent ◽  
Acute Effect ◽  
Human Osteoblast ◽  
Stimulate Bone Resorption ◽  
Na Pump

Palytoxin (PTx) is a potent membrane-active agent produced by marine coelenterates that acts to stimulate bone resorption in organ culture at nanomolar concentrations. We report here the actions of PTx on Na+ and Ca2+ homeostasis in human osteoblast-like Saos-2 cells. PTx induced a rise in the cytosolic free Na+ concentration ([Na]i) by causing entry of extracellular Na+ (Na(e)+). PTx also caused a concentration-dependent biphasic rise in the cytosolic free Ca2+ concentration ([Ca2+]i) by enhancing entry of extracellular Ca2+ (Ca(e)2+). Entry of Na+ was dependent on the presence of Ca(e)2+ and was prevented by the Na+/Ca2+ exchange antagonist 3,4-dichlorobenzamil (DCB). Entry of Ca2+ was dependent on the presence of Na(e)+ but was not prevented by DCB. The actions of PTx on [Na+]i and [Ca2+]i were completely inhibited by pretreatment of the cells with ouabain. Ouabain alone had no acute effect on [Na+]i or [Ca2+]i in Saos-2 cells. We propose that interaction of PTx with the Na+ pump created a channel that allowed influx of Na(e)+ and Ca(e)2+. The rise in [Ca2+]i then stimulated the activity of the plasma membrane Na+/Ca2+ exchanger, which further enhanced Na(e)+ entry.

Interleukin-6 does not stimulate bone resorption in neonatal mouse calvariae

2009 ◽  
Vol 6 (1) ◽  
pp. 3-8 ◽  
Author(s):  
Abdulkarim Al-Humidan ◽  
Stuart H. Ralston ◽  
David E. Hughes ◽  
Karen Chapman ◽  
Lucien Aarden ◽  
...  
Keyword(s):  
Bone Resorption ◽  
Interleukin 6 ◽  
Neonatal Mouse ◽  
Stimulate Bone Resorption

Multiple myeloma cells directly stimulate bone resorption in vitro by down-regulating mature osteoclast apoptosis

2008 ◽  
Vol 32 (8) ◽  
pp. 1279-1287 ◽  
Author(s):  
Iman El Hajj Dib ◽  
Gressier Mélanie ◽  
Salle Valery ◽  
Mentaverri Romuald ◽  
Brazier Michel ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Bone Resorption ◽  
Stimulate Bone Resorption ◽  
Myeloma Cells ◽  
Mature Osteoclast ◽  
Osteoclast Apoptosis

scholarly journals Porphyromonas gingivalis fimbriae stimulate bone resorption in vitro.

1994 ◽  
Vol 62 (7) ◽  
pp. 3012-3016 ◽  
Author(s):  
Y Kawata ◽  
S Hanazawa ◽  
S Amano ◽  
Y Murakami ◽  
T Matsumoto ◽  
...  
Keyword(s):  
Bone Resorption ◽  
Porphyromonas Gingivalis ◽  
Stimulate Bone Resorption

Bacterial components stimulate bone resorption and osteoclast -like cell formation through the generation of 5-lipoxygenase products

Bone ◽  
1995 ◽  
Vol 17 (6) ◽  
pp. 583
Author(s):  
S.P. Nair ◽  
P.A. Hill ◽  
B. Henderson ◽  
M. Harris ◽  
M. Wilson ◽  
...  
Keyword(s):  
Bone Resorption ◽  
Cell Formation ◽  
Stimulate Bone Resorption ◽  
Lipoxygenase Products
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