High-pH drilling fluids are often used for drilling shale gas wells. Alkali erosion of shale is one of the important factors of wellbore instability. Alkali erosion experiments of different kinds of minerals and shale were conducted in this paper. Experimental results show that the corrosion rate of kaolinite is the highest when the pH is 9, the corrosion rate of smectite is the highest when the pH is 10 or 11, and the corrosion rate of the quartz is the highest when the pH is 12. Both shale particle size and concentration of hydroxide ion all affect the reaction rate, and the former has a negative correlation with the reaction rate, and the latter has a positive correlation with the reaction rate. In addition, alkaline erosion can lead to the fracture propagation along the bedding planes of shale, which can easily result in wellbore instability. This study may offer some theoretical basis for wellbore instability induced by high-pH drilling fluids.