Clinical significance of cough intensity and frequency in patients with interstitial lung disease: a cross-sectional study

Abstract Background The intensity and frequency of cough remain unclear in interstitial lung disease (ILD). The aim of this study was to evaluate the intensity and frequency of cough in idiopathic interstitial pneumonias (IIPs), connective tissue disease-associated interstitial lung disease (CTD-ILD), and chronic hypersensitivity pneumonia (CHP), and examine their associations with clinical indices. Methods In this cross-sectional study, the intensity and frequency of cough were evaluated using a 100-mm visual analogue scale. Scores on the Leicester Cough Questionnaire, chronic dyspnoea scale, and a frequency scale for symptoms of gastro-oesophageal reflux disease (FSSG) were collected. The correlations of cough intensity and frequency with potential predictor variables were tested using bivariate and multiple logistic regression analysis. Results The study included 70 patients with IIPs, 49 with CTD-ILD, and 10 with CHP. Patients with IIPs had the most severe cough intensity among the three patient groups. In patients with IIPs, both the intensity and frequency of cough were negatively associated with diffusing capacity of the lung for carbon monoxide and positively with the Composite Physiologic Index (CPI). In CTD-ILD, both the intensity and frequency of cough correlated with a higher FSSG score. In multivariate analysis of patients with ILD, IIPs and the FSSG score was independently associated with both components of cough, and CPI tended to be independently associated with cough frequency alone. Finally, we examined the features of differences between cough intensity and frequency in all patients with ILD. Patients in whom cough frequency was predominant had greater impairment of health status relative to other patients. Conclusions The intensity of cough was greater in IIPs than in other ILDs. Different clinical indices were associated with cough intensity and frequency according to the subtype of ILD. The frequency of cough was more strongly associated with health status than was the intensity of cough. These findings suggest that medical staff could manage patients with ILD by considering cough-related factors when assessing the intensity and frequency of cough.

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Clinical significance of self-reported cough intensity and frequency in patients with interstitial lung disease: a cross-sectional study

BMC Pulmonary Medicine ◽

10.1186/s12890-019-1012-6 ◽

2019 ◽

Vol 19 (1) ◽

Author(s):

Ryuhei Sato ◽

Tomohiro Handa ◽

Hisako Matsumoto ◽

Takeshi Kubo ◽

Toyohiro Hirai

Keyword(s):

Health Status ◽

Interstitial Lung Disease ◽

Lung Disease ◽

Multiple Logistic Regression Analysis ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Cough Frequency ◽

Patient Reported ◽

Clinical Indices

Abstract Background The intensity and frequency of cough remain unclear in interstitial lung disease (ILD). The aim of this study was to evaluate the intensity and frequency of cough in idiopathic interstitial pneumonias (IIPs), connective tissue disease-associated interstitial lung disease (CTD-ILD), and chronic hypersensitivity pneumonia (CHP), and examine their associations with clinical indices. Methods In this cross-sectional study, the intensity and frequency of cough were evaluated using a 100-mm visual analogue scale. Scores on the Leicester Cough Questionnaire, chronic dyspnoea scale, and a frequency scale for symptoms of gastro-oesophageal reflux disease (FSSG) were collected. The correlations of cough intensity and frequency with potential predictor variables were tested using bivariate and multiple logistic regression analysis. Results The study included 70 patients with IIPs, 49 with CTD-ILD, and 10 with CHP. Patients with IIPs had the most severe cough intensity among the three patient groups. In patients with IIPs, both the intensity and frequency of cough were negatively associated with the diffusing capacity of the lung for carbon monoxide and positively with the Composite Physiologic Index (CPI). In CTD-ILD, both the intensity and frequency of cough were correlated with a higher FSSG score. In multivariate analysis of patients with ILD, IIPs and the FSSG score were independently associated with both components of cough, and CPI tended to be independently associated with cough frequency. Finally, we examined the features of the differences between cough intensity and frequency in all patients with ILD. Patients in whom cough frequency was predominant had a greater impairment of health status relative to other patients. Conclusions Cough intensity was greater in IIPs than in other ILDs. Different clinical indices were associated with patient-reported cough intensity and frequency according to the subtype of ILD. Cough frequency was more strongly associated with health status than was cough intensity. These findings suggest that medical staff could manage patients with ILD by considering cough-related factors when assessing the intensity and frequency of cough.

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Clinical significance of self-reported cough intensity and frequency in patients with interstitial lung disease: a cross-sectional study

10.21203/rs.2.12000/v2 ◽

2019 ◽

Author(s):

Ryuhei Sato ◽

Tomohiro Handa ◽

Hisako Matsumoto ◽

Takeshi Kubo ◽

Toyohiro Hirai

Keyword(s):

Health Status ◽

Interstitial Lung Disease ◽

Lung Disease ◽

Multiple Logistic Regression Analysis ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Cough Frequency ◽

Patient Reported ◽

Clinical Indices

Abstract Background: The intensity and frequency of cough remain unclear in interstitial lung disease (ILD). The aim of this study was to evaluate the intensity and frequency of cough in idiopathic interstitial pneumonias (IIPs), connective tissue disease-associated interstitial lung disease (CTD-ILD), and chronic hypersensitivity pneumonia (CHP), and examine their associations with clinical indices. Methods: In this cross-sectional study, the intensity and frequency of cough were evaluated using a 100-mm visual analogue scale. Scores on the Leicester Cough Questionnaire, chronic dyspnoea scale, and a frequency scale for symptoms of gastro-oesophageal reflux disease (FSSG) were collected. The correlations of cough intensity and frequency with potential predictor variables were tested using bivariate and multiple logistic regression analysis. Results: The study included 70 patients with IIPs, 49 with CTD-ILD, and 10 with CHP. Patients with IIPs had the most severe cough intensity among the three patient groups. In patients with IIPs, both the intensity and frequency of cough were negatively associated with diffusing capacity of the lung for carbon monoxide and positively with the Composite Physiologic Index (CPI). In CTD-ILD, both the intensity and frequency of cough correlated with a higher FSSG score. In multivariate analysis of patients with ILD, IIPs and the FSSG score was independently associated with both components of cough, and CPI tended to be independently associated with cough frequency alone. Finally, we examined the features of differences between cough intensity and frequency in all patients with ILD. Patients in whom cough frequency was predominant had greater impairment of health status relative to other patients. Conclusions: The intensity of cough was greater in IIPs than in other ILDs. Different clinical indices were associated with patient-reported cough intensity and frequency according to the subtype of ILD. The frequency of cough was more strongly associated with health status than was the intensity of cough. These findings suggest that medical staff could manage patients with ILD by considering cough-related factors when assessing the intensity and frequency of cough.

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Clinical significance of self-reported cough intensity and frequency in patients with interstitial lung disease: a cross-sectional study

10.21203/rs.2.12000/v3 ◽

2019 ◽

Author(s):

Ryuhei Sato ◽

Tomohiro Handa ◽

Hisako Matsumoto ◽

Takeshi Kubo ◽

Toyohiro Hirai

Keyword(s):

Health Status ◽

Interstitial Lung Disease ◽

Lung Disease ◽

Multiple Logistic Regression Analysis ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Cough Frequency ◽

Patient Reported ◽

Clinical Indices

Abstract Background: The intensity and frequency of cough remain unclear in interstitial lung disease (ILD). The aim of this study was to evaluate the intensity and frequency of cough in idiopathic interstitial pneumonias (IIPs), connective tissue disease-associated interstitial lung disease (CTD-ILD), and chronic hypersensitivity pneumonia (CHP), and examine their associations with clinical indices. Methods: In this cross-sectional study, the intensity and frequency of cough were evaluated using a 100-mm visual analogue scale. Scores on the Leicester Cough Questionnaire, chronic dyspnoea scale, and a frequency scale for symptoms of gastro-oesophageal reflux disease (FSSG) were collected. The correlations of cough intensity and frequency with potential predictor variables were tested using bivariate and multiple logistic regression analysis. Results: The study included 70 patients with IIPs, 49 with CTD-ILD, and 10 with CHP. Patients with IIPs had the most severe cough intensity among the three patient groups. In patients with IIPs, both the intensity and frequency of cough were negatively associated with the diffusing capacity of the lung for carbon monoxide and positively with the Composite Physiologic Index (CPI). In CTD-ILD, both the intensity and frequency of cough were correlated with a higher FSSG score. In multivariate analysis of patients with ILD, IIPs and the FSSG score were independently associated with both components of cough, and CPI tended to be independently associated with cough frequency. Finally, we examined the features of the differences between cough intensity and frequency in all patients with ILD. Patients in whom cough frequency was predominant had a greater impairment of health status relative to other patients. Conclusions: Cough intensity was greater in IIPs than in other ILDs. Different clinical indices were associated with patient-reported cough intensity and frequency according to the subtype of ILD. Cough frequency was more strongly associated with health status than was cough intensity. These findings suggest that medical staff could manage patients with ILD by considering cough-related factors when assessing the intensity and frequency of cough.

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A low prevalence of rapidly progressive interstitial lung disease in Latin American patients with dermatomyositis: A multicenter cross-sectional study

10.47660/cbr.2020.17022 ◽

2021 ◽

Author(s):

Pablo Arturo Olivo Pallo ◽

Leonardo Santos Hoff ◽

Samuel Katsuyuki Shinjo ◽

Jiram Torres ◽

Amelia Granel

Keyword(s):

Interstitial Lung Disease ◽

Lung Disease ◽

Latin American ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Low Prevalence

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A Comparative Study of the Sarcopenia Screening in Older Patients with Interstitial Lung Disease

10.21203/rs.3.rs-936545/v1 ◽

2021 ◽

Author(s):

Masatoshi Hanada ◽

Noriho Sakamoto ◽

Hiroshi Ishimoto ◽

Takashi Kido ◽

Takuto Miyamura ◽

...

Keyword(s):

Interstitial Lung Disease ◽

Lung Disease ◽

Operating Characteristic ◽

Cross Sectional Study ◽

Screening Tools ◽

Calf Circumference ◽

Sectional Study ◽

Cross Sectional ◽

Receiver Operating Characteristic Curves ◽

Climbing Stairs

Abstract Background: The calf circumference (CalF), the strength, assistance in walking, rising from a chair, climbing stairs, and falls (SARC-F) and the SARC-CalF questionnaires for sarcopenia screening have been used by Asian Working Group for Sarcopenia 2019 (AWGS 2019). The aim of this study was to assess accuracy of these three sarcopenia screening tools in patients with interstitial lung disease. Methods: In this cross-sectional study, stable patients with interstitial lung disease were enrolled. The SARC-F, SARC-CalF, and CalF, used in patients with interstitial lung disease, were compared to the diagnostic criteria proposed by AWGS 2019. The accuracy of screening tools was compared using sensitivity and specificity. Moreover, areas under the receiver operating characteristic curves (AUC) were computed. Results: Seventy eight patients were analyzed, and sarcopenia was identified in 25 (32.1%) patients with interstitial lung disease by the AWGS 2019 criteria. The sensitivity of the CalF was highest (96%) of the three screening tools, while the specificity was 60%. The sensitivity of SARC-F and SARC-CalF were 24% and 68%, while the specificity were 92% and 66%, respectively. The AUCs of CalF, SARC-F, and SARC-CalF in all patients were 0.78, 0.58, and 0.67, respectively. Conclusions: The CalF is most suitable for screening sarcopenia in patients with interstitial lung disease, while SARC-F and SARC-CalF are not.

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Oral health status of patients infected with human immunodeficiency virus and related factors, Iran: a cross-sectional study

BMC Oral Health ◽

10.1186/s12903-021-02002-3 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Soheila Shaghaghian ◽

Mojtaba Homayooni ◽

Maryam Amin ◽

Fahimeh Rezazadeh

Keyword(s):

Human Immunodeficiency Virus ◽

Health Status ◽

Oral Health ◽

Cross Sectional Study ◽

Oral Health Status ◽

Sectional Study ◽

Related Factors ◽

Cross Sectional ◽

Immunodeficiency Virus ◽

Dmft Index

Abstract Background Human immunodeficiency virus (HIV) continues to be a major global issue. HIV-infected patients commonly experience oral health problems. This study aimed to assess oral health status of the patients and its related factors in Shiraz, Iran. Methods In this cross-sectional study, by using simple random sampling, 250 HIV-infected patients were selected from Shiraz Voluntary Counseling and Testing Center in 2019. Patients' decayed, missing, and filled tooth (DMFT) index, plaque index (PI), and community periodontal index (CPI) were determined. Associations between patients' characteristics and the above-mentioned indices were examined by using Pearson correlation, one-way ANOVA, chi-square, and independent sample T test. The effect of possible confounding factors was controlled by using multiple linear regression and logistic models. Results Of the 222 participants, 111 (50%) had 15 or more missing teeth and 79 (35.6%) were edentulous. Their mean (SD) DMFT and PI were 20.71 (10.74) and 1.11 (0.79), respectively. About 40% of them had healthy gingiva. DMFT (p < 0.001), PI (p < 0.001), and CPI (p = 0.002) were significantly worse in men than women. The patients' DMFT and edentulous status were significantly associated with their age (both p < 0.001) and duration of disease (p = 0.001 and p = 0.008, respectively). Unemployed patients had the worst DMFT, PI, and CPI (all p < 0.001) and the highest percentage of edentulous individuals (p = 0.003). All examined indices were significantly worse in cigarette smokers, alcoholics, addicts, and patients with a previous history of imprisonment (all p < 0.001). The odds ratio of being edentulous was 5.74 times in addicted patients than in non-addicted ones (p < 0.001). The odds increased 0.11 with every year that the patients' age increased (p < 0.001). Multiple linear regression models also showed that the addicted patients had significantly more scores in DMFT index, PI, and CPI (all p < 0.001). Conclusions Overall, oral health status of the HIV-infected patients was unsatisfactory. Therefore, effective interventional programs are needed for prevention and early treatment of dental problems among this population, especially for more vulnerable groups such as older men with low socioeconomic status, and those with high-risk behaviors.

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Oral Health Status of Patients Infected with Human Immunodeficiency Virus and Related Factors, Iran: A Cross- Sectional Study

10.21203/rs.3.rs-692109/v1 ◽

2021 ◽

Author(s):

Soheila Shaghaghian ◽

Mojtaba Homayooni ◽

Maryam Amin ◽

Fahimeh Rezazadeh

Keyword(s):

Human Immunodeficiency Virus ◽

Health Status ◽

Oral Health ◽

Cross Sectional Study ◽

Oral Health Status ◽

Sectional Study ◽

Related Factors ◽

Cross Sectional ◽

Periodontal Index ◽

Immunodeficiency Virus

Abstract Background: Human immunodeficiency virus (HIV) continues to be a major global issue. HIV-infected patients commonly experience oral health problems. This study aimed to assess oral health status of the patients and its related factors in Shiraz, Iran.Methods: In this cross-sectional study, by using simple random sampling, 250 HIV-infected patients were selected from Shiraz Voluntary Counseling and Testing Center in 2019. Patients' decayed, missing, and filled tooth (DMFT) index, plaque index (PI), and community periodontal index (CPI) were determined. Associations between patients' characteristics and the above-mentioned indices were examined by using Pearson correlation, one way ANOVA, chi-square, and independent sample T test. Results: Of the 222 participants, 111 (50%) had 15 or more missed teeth and 79 (35.6%) were edentulous. Their mean (SD) DMFT and PI were 20.71 (10.74) and 1.11 (0.79), respectively. About 40% of them had healthy gingiva. DMFT (p<0.001), PI (p<0.001), and CPI (p=0.002) were significantly worse in men than women. The patients' DMFT and edentulous status were significantly associated with their age (both p<0.001) and duration of disease (p=0.001 and p=0.008, respectively). Unemployed patients had the worst DMFT, PI, and CPI (all p<0.001) and the highest percentage of edentulous individuals (p=0.003). All examined indices were significantly worse in cigarette smokers, alcoholics, addicts, and patients with a previous history of imprisonment (all p<0.001).Conclusions: Overall, oral health status of the HIV-infected patients was unsatisfactory, which might indicate their inadequate access to dental services. Therefore, effective interventional programs are needed for prevention and early treatment of dental problems among this population, especially for more vulnerable groups such as older men with low socioeconomic status, and those with high-risk behaviors.

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Characteristics of Chronic Cough in adults in Pakistani population: A cross sectional study

Pakistan Journal of Medical Sciences ◽

10.12669/pjms.36.3.1868 ◽

2020 ◽

Vol 36 (3) ◽

Author(s):

Kaleem Ullah Toori ◽

Asma Chaudhry

Keyword(s):

Allergic Rhinitis ◽

Interstitial Lung Disease ◽

Lung Disease ◽

Chronic Cough ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Pakistani Population ◽

Cough Variant Asthma ◽

Creative Commons

Background and Objective: Data about causes of chronic cough are lacking in our part of world. The aim of our study was to look for spectrum of causes in our setup and to determine a correlation between causes of cough and baseline factors of age, gender, and BMI and compare it to other populations. Methods: Total 236 chronic cough patients who attended chest clinic at KRL Hospital Islamabad from January 2018 to June 2019 were included in this cross-sectional study. Chronic cough was defined as cough greater than eight weeks. Main causes of chronic cough taken were cough variant asthma, allergic rhinitis, interstitial lung disease, Gastro-esophageal reflux disease, bronchial hyper-reactivity, ACE-I induced cough and others’. Other demographic and clinical data were also recorded. Results: The mean age was 45.16± 16.50 years and BMI was 26.23 ± 4.68kg/m2. Major cause of chronic cough was cough variant asthma in 111(47%). Age had significant positive correlations with ILD, ACE-I induced cough and CCF, while significant negative correlations with CVA and AR. On gender correlation, ILD and ACE-I cough were significantly found more in females. BMI had significant correlation with ACE-I cough only. Conclusion: Variability of epidemiology of cough variant asthma, allergic rhinitis and ACE-I induced cough is comparable to worldwide data while differences exist with epidemiology of interstitial lung disease. Further research is needed in the field to delineate the local trends in this regard and compare to other population groups. doi: https://doi.org/10.12669/pjms.36.3.1868 How to cite this:Toori KU, Chaudhry A. Characteristics of Chronic Cough in adults in Pakistani population: A cross sectional study. Pak J Med Sci. 2020;36(3):---------. doi: https://doi.org/10.12669/pjms.36.3.1868 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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