Genetic characterization of highly pathogenic avian influenza A (H5N8) virus isolated from domestic geese in Iraq, 2018
Abstract After the circulation of H5N1 in 2006, 2015 and 2016 in Iraq, a new H5N8 influenza virus emerged in Iraq in 2018. In this study, a HPAI virus subtype H5N8 was identified from backyard domestic geese in Kurdistan region, Iraq. Phylogenic analyses of the hemagglutinin (HA) and neuraminidase (NA) genes indicated that Iraq H5N8 viruses belonged to clade 2.3.4.4 group B and clustered with isolates from Iran, Israel and Belgium. Genetic analysis of HA of the Iraq H5N8 indicated molecular markers for avian-type receptors. Characterization of the NA gene showed that the virus had sensitive molecular markers for antiviral drugs. This is the first study ever on H5N8 in Iraq and it is crucial to understand the epidemiology of the viruses in Iraq and the Middle East. The results are suggestive of a possible role of migratory birds in the introduction of HPAI subtype H5N8 into Iraq.