scholarly journals Regulatory role of programmed cell death 4 in precancerous gastric lesions and early gastric cancer

2019 ◽  
Author(s):  
Yaodong Zhu ◽  
Lei Liu ◽  
Qiang Peng ◽  
He Ba ◽  
Wanji Song ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cell Death ◽  
Early Gastric Cancer ◽  
Programmed Cell Death ◽  
Gastric Lesions ◽  
Precancerous Gastric Lesions ◽  
Associated Proteins ◽  
Programmed Cell Death 4 ◽  
Cancer Tissues

Abstract Background Programmed cell death 4 (PDCD4) as a newly identified tumor suppressor is involved in inhibiting tumorigenesis and tumor progression. Epithelial mesenchymal Transition (EMT) is also associated with tumorgenesis of gastric cancer. However, few studies have elucidated the role of PDCD4 in regulation of EMT during precancerous gastric lesions (PLGC) and early gastric cancer. Methods In this study, the expression of PDCD4 and EMT-associated proteins in PLGC and early gastric cancer tissues were detected by immunohistochemistry. The relationship between the expression of PDCD4 and EMT-associated proteins and clinical and pathological parameters were analyzed. The PDCD4 high-expressed SGC-7901 cell line was also used to evaluate the function of PDCD4 in vitro and in vivo. Results PDCD4 and EMT associated proteins expression were significantly altered in PLGC and early gastric cancer tissues. After transfection with the PDCD4 gene, the expression of E-cadherin was significantly increased, the expression of N-cadherin and Vimentin were also remarkably inhibited. PDCD4 high-expressed also inhibited tumor growth and pathological features in nude mice xenograft model. Conclusion This study elucidates a regulatory role of PDCD4 in PLGC and early gastric cancer and provide insights into EMT-associated target which may provide novel therapeutic recourse.

scholarly journals Role of microRNA-21 and programmed cell death 4 in the pathogenesis of human uterine leiomyomas

2012 ◽  
Vol 98 (3) ◽  
pp. 726-734.e2 ◽  
Author(s):  
J. Browning Fitzgerald ◽  
Vargheese Chennathukuzhi ◽  
Faezeh Koohestani ◽  
Romana A. Nowak ◽  
Lane K. Christenson
Keyword(s):  
Cell Death ◽  
Programmed Cell Death ◽  
Uterine Leiomyomas ◽  
Programmed Cell Death 4

scholarly journals Linc00472 suppresses breast cancer progression and enhances doxorubicin sensitivity through regulation of miR-141 and programmed cell death 4

RSC Advances ◽  
2018 ◽  
Vol 8 (16) ◽  
pp. 8455-8468 ◽  
Author(s):  
Pengwei Lu ◽  
Xue Yang Xue Yang ◽  
Yunqing Yang ◽  
Fang Wang ◽  
Lin Li ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Death ◽  
Programmed Cell Death ◽  
Cancer Progression ◽  
Breast Cancer Progression ◽  
Programmed Cell Death 4 ◽  
Cancer Tissues

Linc00472 expression was down-regulated in breast cancer tissues and cells, and was associated with the development and prognosis of breast cancer.

scholarly journals Role of programmed cell death 4 in diseases: a double-edged sword

2017 ◽  
Vol 14 (11) ◽  
pp. 884-886 ◽  
Author(s):  
Yang Jiang ◽  
Yufeng Jia ◽  
Lining Zhang
Keyword(s):  
Cell Death ◽  
Programmed Cell Death ◽  
Programmed Cell Death 4

Defining the regulatory role of programmed cell death 4 in laryngeal squamous cell carcinoma

2018 ◽  
Vol 96 (5) ◽  
pp. 522-538 ◽  
Author(s):  
Yuan-Teng Xu ◽  
Rui-Qing Chen ◽  
Gong-Biao Lin ◽  
Xiu-Ling Fang ◽  
Shu-Juan Yu ◽  
...  
Keyword(s):  
Cell Death ◽  
Programmed Cell Death ◽  
Laryngeal Carcinoma ◽  
Malignant Tumors ◽  
Clinical Stage ◽  
Regulatory Relationship ◽  
Novel Therapy ◽  
Programmed Cell Death 4 ◽  
E Cadherin

Programmed cell death 4 (PDCD4) is decreased in many different kinds of malignant tumors. EMT endows tumor cells invasive and metastatic properties. However, few studies have determined the role of PDCD4 in the regulation of EMT in the context of laryngeal carcinoma. We examined the relationship between PDCD4 and EMT-associated proteins E-cadherin and N-cadherin using laryngeal carcinoma tissues. Gene manipulation was used to define the regulatory capacity of PDCD4. We report that PDCD4 and E-cadherin/N-cadherin expression were significantly changed in the carcinoma tissues, and their expression was associated with pathological grade, metastatic state, and clinical stage. The suppression of PDCD4 (and consequently, E-cadherin) was concomitant with increased proliferation and G2-phase arrest, decreased apoptosis, and increased cell invasion. PDCD4 upregulation reversed the above-mentioned results. In nude mice, PDCD4 knockdown increased tumor growth and pathological features, confirming the tumorigenic role of PDCD4. Finally, PDCD4 silencing was associated with dysregulation of the carcinogenic Wnt–β-catenin and the STAT3–miR-21 signaling pathways. This study revealed a dynamic regulatory relationship between PDCD4 and critical factors for EMT, establishing a broad, functional role for PDCD4 in laryngeal carcinoma, which may be propagated by the STAT3–miR-21 pathway. These findings provide new information on an EMT-associated target that may lead to a novel therapy.

scholarly journals Mir-421 in plasma as a potential diagnostic biomarker for precancerous gastric lesions and early gastric cancer

PeerJ ◽  
2019 ◽  
Vol 7 ◽  
pp. e7002 ◽  
Author(s):  
Jianlin Chen ◽  
Lihua Wu ◽  
Yifan Sun ◽  
Qi Yin ◽  
Xianhua Chen ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Early Gastric Cancer ◽  
Tumor Markers ◽  
Cancer Progression ◽  
Early Stage ◽  
Precancerous Lesions ◽  
Youden Index ◽  
Gastric Lesions ◽  
Precancerous Gastric Lesions ◽  
Potential Biomarker

Objective MicroRNA (miR)-421 plays a key role in cancer progression. It has been reported that circulating miR-421may be a potential tumor marker for the diagnosis of several cancers. However, the role of miR-421 in plasma as a potential biomarker in the diagnosis of precancerous gastric lesions (Pre) and early-stage gastric cancer (GC) remains poorly understood. In this study, we investigated miR-421 in plasma as a novel potential biomarker for the detection of precancerous gastric lesions and early-stage (GC). Materials & Methods The miRNA content was determined by quantitative real-time polymerase chain reaction (qRT-PCR). MiR-421 content in all subjects was normalized by endogenous miRNA (miR-16). The diagnostic value of miR-421 for Pre and GC was assessed by comparing receiver operating characteristic (ROC) analysis with traditional tumor markers, including CEA, CA125, CA153, CA211 and CA50. The correlation between the expression of miR-421 and the pathological characteristics of Pre and GC was analyzed. Results Elevated expression of miR-421 in plasma can robustly distinguish the normal population from Pre and GC cases, especially in the early stages of gastric cancer cases (all p < 0.05). The ROC analyses showed that the area under the ROC curve (AUC), sensitivity, accuracy and Youden index of miR-421 were superior to traditional tumor markers (CEA, CA125, CA153, CA211, and CA50) in GC diagnosis, while its specificity was higher than CEA, CA153 and CA50 (all p < 0.05). MiR-421 in plasma had higher AUC value than AFP, CA153, CA211 and CA50 in the diagnosis of Pre (all p < 0.05), while specificity, accuracy and Youden index of miR-421 was only lower than CA211. The efficiency of miR-421 in the diagnosis of GC was significantly higher than that of CA211 and CA50, and it was significantly higher than CA153, CA211 and CA50 in the diagnosis of Pre (all p < 0.05). In addition, up-regulation of miR-421 occurred initially in precancerous gastric lesions as well as in the early stage of GC. Conclusions Overexpression of plasma miR-421 is a novel biomarker for the detection of precancerous lesions and early gastric cancer.

scholarly journals Proteomic profiling identifies signatures associated with progression of precancerous gastric lesions and risk of early gastric cancer

EBioMedicine ◽  
2021 ◽  
Vol 74 ◽  
pp. 103714
Author(s):  
Xue Li ◽  
Nai-Ren Zheng ◽  
Lin-Heng Wang ◽  
Zhong-Wu Li ◽  
Zong-Chao Liu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Early Gastric Cancer ◽  
Gastric Lesions ◽  
Proteomic Profiling ◽  
Precancerous Gastric Lesions
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