scholarly journals Systematic alphanumeric-coded endoscopy versus chromoendoscopy for the detection of precancerous gastric lesions and early gastric cancer in subjects at average risk for gastric cancer

2018 ◽  
Vol 83 (2) ◽  
pp. 117-124
Author(s):  
A. Pérez-Mendoza ◽  
Á.M. Zárate-Guzmán ◽  
E.S. Galvis García ◽  
S. Sobrino Cossío ◽  
J. Djamus Birch
Keyword(s):  
Gastric Cancer ◽  
Early Gastric Cancer ◽  
Average Risk ◽  
Gastric Lesions ◽  
Precancerous Gastric Lesions

scholarly journals Mir-421 in plasma as a potential diagnostic biomarker for precancerous gastric lesions and early gastric cancer

PeerJ ◽  
2019 ◽  
Vol 7 ◽  
pp. e7002 ◽  
Author(s):  
Jianlin Chen ◽  
Lihua Wu ◽  
Yifan Sun ◽  
Qi Yin ◽  
Xianhua Chen ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Early Gastric Cancer ◽  
Tumor Markers ◽  
Cancer Progression ◽  
Early Stage ◽  
Precancerous Lesions ◽  
Youden Index ◽  
Gastric Lesions ◽  
Precancerous Gastric Lesions ◽  
Potential Biomarker

Objective MicroRNA (miR)-421 plays a key role in cancer progression. It has been reported that circulating miR-421may be a potential tumor marker for the diagnosis of several cancers. However, the role of miR-421 in plasma as a potential biomarker in the diagnosis of precancerous gastric lesions (Pre) and early-stage gastric cancer (GC) remains poorly understood. In this study, we investigated miR-421 in plasma as a novel potential biomarker for the detection of precancerous gastric lesions and early-stage (GC). Materials & Methods The miRNA content was determined by quantitative real-time polymerase chain reaction (qRT-PCR). MiR-421 content in all subjects was normalized by endogenous miRNA (miR-16). The diagnostic value of miR-421 for Pre and GC was assessed by comparing receiver operating characteristic (ROC) analysis with traditional tumor markers, including CEA, CA125, CA153, CA211 and CA50. The correlation between the expression of miR-421 and the pathological characteristics of Pre and GC was analyzed. Results Elevated expression of miR-421 in plasma can robustly distinguish the normal population from Pre and GC cases, especially in the early stages of gastric cancer cases (all p < 0.05). The ROC analyses showed that the area under the ROC curve (AUC), sensitivity, accuracy and Youden index of miR-421 were superior to traditional tumor markers (CEA, CA125, CA153, CA211, and CA50) in GC diagnosis, while its specificity was higher than CEA, CA153 and CA50 (all p < 0.05). MiR-421 in plasma had higher AUC value than AFP, CA153, CA211 and CA50 in the diagnosis of Pre (all p < 0.05), while specificity, accuracy and Youden index of miR-421 was only lower than CA211. The efficiency of miR-421 in the diagnosis of GC was significantly higher than that of CA211 and CA50, and it was significantly higher than CA153, CA211 and CA50 in the diagnosis of Pre (all p < 0.05). In addition, up-regulation of miR-421 occurred initially in precancerous gastric lesions as well as in the early stage of GC. Conclusions Overexpression of plasma miR-421 is a novel biomarker for the detection of precancerous lesions and early gastric cancer.

scholarly journals Proteomic profiling identifies signatures associated with progression of precancerous gastric lesions and risk of early gastric cancer

EBioMedicine ◽  
2021 ◽  
Vol 74 ◽  
pp. 103714
Author(s):  
Xue Li ◽  
Nai-Ren Zheng ◽  
Lin-Heng Wang ◽  
Zhong-Wu Li ◽  
Zong-Chao Liu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Early Gastric Cancer ◽  
Gastric Lesions ◽  
Proteomic Profiling ◽  
Precancerous Gastric Lesions

scholarly journals Regulatory role of programmed cell death 4 in precancerous gastric lesions and early gastric cancer

2019 ◽  
Author(s):  
Yaodong Zhu ◽  
Lei Liu ◽  
Qiang Peng ◽  
He Ba ◽  
Wanji Song ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cell Death ◽  
Early Gastric Cancer ◽  
Programmed Cell Death ◽  
Gastric Lesions ◽  
Precancerous Gastric Lesions ◽  
Associated Proteins ◽  
Programmed Cell Death 4 ◽  
Cancer Tissues

Abstract Background Programmed cell death 4 (PDCD4) as a newly identified tumor suppressor is involved in inhibiting tumorigenesis and tumor progression. Epithelial mesenchymal Transition (EMT) is also associated with tumorgenesis of gastric cancer. However, few studies have elucidated the role of PDCD4 in regulation of EMT during precancerous gastric lesions (PLGC) and early gastric cancer. Methods In this study, the expression of PDCD4 and EMT-associated proteins in PLGC and early gastric cancer tissues were detected by immunohistochemistry. The relationship between the expression of PDCD4 and EMT-associated proteins and clinical and pathological parameters were analyzed. The PDCD4 high-expressed SGC-7901 cell line was also used to evaluate the function of PDCD4 in vitro and in vivo. Results PDCD4 and EMT associated proteins expression were significantly altered in PLGC and early gastric cancer tissues. After transfection with the PDCD4 gene, the expression of E-cadherin was significantly increased, the expression of N-cadherin and Vimentin were also remarkably inhibited. PDCD4 high-expressed also inhibited tumor growth and pathological features in nude mice xenograft model. Conclusion This study elucidates a regulatory role of PDCD4 in PLGC and early gastric cancer and provide insights into EMT-associated target which may provide novel therapeutic recourse.

Meta-analysis: The diagnostic efficacy of chromoendoscopy for early gastric cancer and premalignant gastric lesions

2016 ◽  
Vol 31 (9) ◽  
pp. 1539-1545 ◽  
Author(s):  
Zhanwei Zhao ◽  
Zifang Yin ◽  
Shiqi Wang ◽  
Juan Wang ◽  
Bing Bai ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Early Gastric Cancer ◽  
Meta Analysis ◽  
Gastric Lesions ◽  
Diagnostic Efficacy

Detection of precancerous gastric lesions and gastric cancer through exhaled breath

Gut ◽  
2015 ◽  
Vol 65 (3) ◽  
pp. 400-407 ◽  
Author(s):  
Haitham Amal ◽  
Marcis Leja ◽  
Konrads Funka ◽  
Roberts Skapars ◽  
Armands Sivins ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Exhaled Breath ◽  
Gastric Lesions ◽  
Precancerous Gastric Lesions

scholarly journals Expression of Cancer Stem Cell Marker CD44 and Its Polymorphisms in Patients with Chronic Gastritis, Precancerous Gastric Lesion, and Gastric Cancer: A Cross-Sectional Multicenter Study in Thailand

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Taweesak Tongtawee ◽  
Wareeporn Wattanawongdon ◽  
Theeraya Simawaranon ◽  
Soraya Kaewpitoon ◽  
Sivamate Kaengpenkae ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Protein Expression ◽  
Cancer Patients ◽  
Chronic Gastritis ◽  
Stem Cell Marker ◽  
Gastric Lesions ◽  
Cd44 Expression ◽  
Precancerous Gastric Lesions ◽  
Significant Difference ◽  
Gastric Cancer Patients

Here we investigated CD44 protein expression and its polymorphisms in patients with chronic gastritis, precancerous gastric lesions, and gastric cancer; and we evaluated our result with the risk of CD44 protein expression and clinicopathological characteristics. Our results obtained by analyzing 162 gastric cancer patients, 125 chronic gastritis, and 165 precancerous gastric lesions from three study centers in Thailand showed that CD44 expression was significantly higher in patients with precancerous gastric lesions and gastric cancer while patients with chronic gastritis were negative for CD44 staining (p=0.036). We further observed the significant association of variant genotype; gastric cancer patients carrying AG or GG of CD44 rs187116 had more increased risk of CD44 expression than wild-type (WT) carriers (AG: odds ratio (OR) = 5.67; 95% CI = 1.57–7.23; p=0.024 and GG: OR = 8.32; 95% CI = 2.94–11.42; p=0.016), but no significant difference in the risk of CD44 expression due to polymorphism in patients with precancerous gastric lesions. Our results suggested that CD44 expression could be used as a marker for the prediction of gastric cancer development, particularly in patients with precancerous gastric lesions carrying AG or GG, who were selected to surveillance follow-up for gastric cancer prevention.

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