scholarly journals The material quality of a new hydrophobic acrylic intraocular lens

2019 ◽  
Author(s):  
Timur M. Yildirim ◽  
Hui Fang ◽  
Sonja K. Schickhardt ◽  
Qiang Wang ◽  
Patrick R. Merz ◽  
...  
Keyword(s):  
Stress Test ◽  
Mean Value ◽  
Laboratory Method ◽  
Intraocular Lenses ◽  
Fort Worth ◽  
In Vitro Stress ◽  
Vision Care ◽  
Hydrophobic Acrylic

Abstract Background The formation of fluid-filled microvacuoles, termed glistenings, is a common complication of intraocular lenses (IOLs) made from hydrophobic acrylate. Using our well established in-vitro laboratory method, we evaluated a new IOL material’s resistance to glistenings formation. Methods An in-vitro stress test for glistenings induction was performed on twenty samples of hydrophobic acrylic IOLs: ten of the new Eyecryl ASHFY600 (Biotech Vision Care, Ahmedabad, India) compared with ten samples of AcrySof IQ SN60WF (Alcon, Fort Worth, USA). The number of microvacuoles per square millimetre (MV/mm 2 ) was evaluated in five sections of each IOL. The results for each model were compared and rated on the Miyata Scale for grading glistening severity. Results In all cases, glistenings number was higher in the central section of the IOL optic than in the periphery. Mean number of MV/mm 2 was highest in the central part of the AcrySof IQ SN60WF, with 41.84 (±27.67) MVs/mm 2 . The lowest number of glistenings was found in the five sections of the Eyecryl ASHFY600 with 0.52 (±0.24) MVs/mm 2 . Mean value of the Eyecryl ASHFY600 IOL, using the Miyata Scale, was Zero. Conclusion In this in-vitro laboratory study, the new hydrophobic acrylic IOL showed a high resistance to microvacuole formation. In clinical use, one can confidently expect glistenings numbers will be low and clinically irrelevant in the Eyecryl ASHFY600.

scholarly journals Glistening formation in a new hydrophobic acrylic intraocular lens

2020 ◽  
Author(s):  
Timur M. Yildirim ◽  
Hui Fang ◽  
Sonja K. Schickhardt ◽  
Qiang Wang ◽  
Patrick R. Merz ◽  
...  
Keyword(s):  
Stress Test ◽  
In Vitro Study ◽  
Mean Value ◽  
Laboratory Method ◽  
Intraocular Lenses ◽  
Fort Worth ◽  
In Vitro Stress ◽  
Vision Care ◽  
Hydrophobic Acrylic

Abstract Background: The formation of fluid-filled microvacuoles, termed glistenings, is a common complication of intraocular lenses (IOLs) made from hydrophobic acrylate. Using our well-established in-vitro laboratory method, we evaluated a new IOL material’s resistance to glistening formation. Methods: An in-vitro stress test for glistening induction was performed on twenty samples of hydrophobic acrylic IOLs: ten of the new Eyecryl ASHFY600 (Biotech Vision Care, Ahmedabad, India) compared with ten samples of AcrySof IQ SN60WF (Alcon, Fort Worth, USA). The number of microvacuoles per square millimetre (MV/mm 2 ) was evaluated in five sections of each IOL. The results for each model were compared and rated on the Miyata Scale for grading glistening severity. Results: In all cases, glistening number was higher in the central section of the IOL optic than in the periphery. Mean number of MV/mm 2 was highest in the central part of the AcrySof IQ SN60WF, with 41.84 (±27.67) MVs/mm². The lowest number of glistenings was found in the five sections of the Eyecryl ASHFY600 with 0.52 (±0.24) MVs/mm². Mean value of the Eyecryl ASHFY600 IOL, using the Miyata Scale, was Zero. Conclusion: In this in-vitro laboratory study, the new hydrophobic acrylic IOL showed a high resistance to microvacuole formation. Results from this in-vitro study suggest that glistening numbers will be low in clinical use in the Eyecryl ASHFY600.

scholarly journals Glistening formation in a new hydrophobic acrylic intraocular lens

2020 ◽  
Author(s):  
Timur M. Yildirim ◽  
Hui Fang ◽  
Sonja K. Schickhardt ◽  
Qiang Wang ◽  
Patrick R. Merz ◽  
...  
Keyword(s):  
Stress Test ◽  
In Vitro Study ◽  
Mean Value ◽  
Laboratory Method ◽  
Intraocular Lenses ◽  
Fort Worth ◽  
In Vitro Stress ◽  
Vision Care ◽  
Hydrophobic Acrylic

Abstract Background: The formation of fluid-filled microvacuoles, termed glistenings, is a common complication of intraocular lenses (IOLs) made from hydrophobic acrylate. Using our well-established in-vitro laboratory method, we evaluated a new IOL material’s resistance to glistening formation.Methods: An in-vitro stress test for glistening induction was performed on twenty samples of hydrophobic acrylic IOLs: ten of the new Eyecryl ASHFY600 (Biotech Vision Care, Ahmedabad, India) compared with ten samples of AcrySof IQ SN60WF (Alcon, Fort Worth, USA). The number of microvacuoles per square millimetre (MV/mm2) was evaluated in five sections of each IOL. The results for each model were compared and rated on the Miyata Scale for grading glistening severity.Results: In all cases, glistening number was higher in the central section of the IOL optic than in the periphery. Mean number of MV/mm2 was highest in the central part of the AcrySof IQ SN60WF, with 41.84 (±27.67) MVs/mm². The lowest number of glistenings was found in the five sections of the Eyecryl ASHFY600 with 0.52 (±0.24) MVs/mm². Mean value of the Eyecryl ASHFY600 IOL, using the Miyata Scale, was Zero.Conclusion: In this in-vitro laboratory study, the new hydrophobic acrylic IOL showed a high resistance to microvacuole formation. Results from this in-vitro study suggest that glistening numbers will be low in clinical use in the Eyecryl ASHFY600.

scholarly journals In-vitro glistening formation in six different foldable hydrophobic intraocular lenses

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Tamer Tandogan ◽  
Gerd U. Auffarth ◽  
Hyeck-Soo Son ◽  
Patrick Merz ◽  
Chul Young Choi ◽  
...  
Keyword(s):  
Image Analysis ◽  
Laboratory Method ◽  
Intraocular Lenses ◽  
Analysis Program ◽  
Quality Of Vision ◽  
Different Types ◽  
The Mean ◽  
Hydrophobic Acrylic

Abstract Background Glistenings describe small, refractile microvacuoles that may arise within the intraocular lens (IOL) material and reduce the patients’ quality of vision. Lenses composed of hydrophobic acrylic material are particularly affected by glistening formation. In this study, we compared the tendency of glistening formation in six different types of hydrophobic acrylic intraocular lenses (IOLs). Methods We used a well-established accelerated laboratory method to develop glistenings in the following IOLs: Vivinex XY1 (Hoya), AcrySof SN60WF (Alcon), Tecnis ZCB00 (AMO), Avansee PN6A (Kowa), Aktis SP NS-60YG (Nidek), and CT Lucia 601P (Zeiss). IOLs were first immersed in saline at 45 °C for 24 h and then at 37 °C for 2.5 h in a water bath. Microvacuole (MV) density and size (Miyata grading) were documented and calculated using an image analysis program. Results The mean glistening density [MV/mm2] and mean Miyata grading (in brackets) were: Vivinex: 11.6 ± 5.7 (0), SN60WF: 264.4 ± 110.3 (2.6), Tecnis: 6.0 ± 2.8 (0), Avansee: 2.2 ± 0.7 (0), Aktis: 851.4 ± 59.4 (3+) and CT Lucia: 71.0 ± 71.6 (1). Conclusions While all tested IOLs showed glistenings with the accelerated laboratory method, the Aktis and SN60WF showed the highest microvacuole density, followed by the CT Lucia. In comparison, the Vivinex, Tecnis, and Avansee IOLs showed far fewer number of glistenings.

scholarly journals Comparative analysis of in vitro accelerated glistening formation in foldable hydrophobic intraocular lenses

2021 ◽  
Author(s):  
Tamer Tandogan ◽  
Gerd U. Auffarth ◽  
Chul Young Choi ◽  
Hyeck-Soo Son ◽  
Ramin Khoramnia
Keyword(s):  
Image Analysis ◽  
Comparative Analysis ◽  
Clinical Results ◽  
Laboratory Method ◽  
High Density ◽  
Intraocular Lenses ◽  
Analysis Program ◽  
Different Types ◽  
Hydrophobic Acrylic

Abstract Purpose To analyse and compare the propensity to form glistenings in 4 different types of hydrophobic acrylic intraocular lenses (IOLs): Alcon AcrySof ® MA60AC, HOYA iSert® PC-60AD, Bausch&Lomb enVista, and Kowa Avansee™ PU6A. Methods We used an accelerated laboratory method to create glistenings. IOLs were first immersed in saline at 45 °C for 24 h and then at 37 °C for 2.5 h. Microvacuole (MV) density and size were documented and calculated using an image analysis program. Results Median density of glistenings [MV/mm2] for Alcon AcrySof ® MA60AC was 623 (range 507–804), for HOYA iSert® PC-60AD 1358 (range 684–2699), for Bausch&Lomb enVista 2 (range 1–2), and for Kowa Avansee™ PU6A 1 (range 1–4). The prevailing MV size was: 0–5 µm for Hoya IOLs, 5–10 µm for Alcon IOLs, 20–50 µm for Bausch&Lomb IOLs, and 5–50 µm for Kowa IOLs. Conclusions Glistenings could be induced in all studied IOLs using the accelerated laboratory method. The Alcon AcrySof ® MA60AC and HOYA iSert® PC-60AD IOLs showed MV of high density, while the glistenings in the Hoya IOLs were smaller in size compared to the Alcon IOLs. The MV density was minimal in the Bausch&Lomb enVista and Kowa Avansee™ PU6A IOLs. The propensity of the Alcon AcrySof ® MA60AC IOLs to form glistenings in vitro correlated with the findings of clinical results that are already published.

scholarly journals Quantitative evaluation of microvacuole formation in five intraocular lens models made of different hydrophobic materials

PLoS ONE ◽  
2021 ◽  
Vol 16 (4) ◽  
pp. e0250860
Author(s):  
Timur M. Yildirim ◽  
Sonja K. Schickhardt ◽  
Qiang Wang ◽  
Elfriede Friedmann ◽  
Ramin Khoramnia ◽  
...  
Keyword(s):  
Intraocular Lenses ◽  
Laboratory Model ◽  
Copolymer Composition ◽  
Fort Worth ◽  
Clinical Use ◽  
Acrylic Copolymer ◽  
Santa Ana ◽  
Hydrophobic Materials ◽  
Hydrophobic Acrylic

In this laboratory study, we assessed the resistance to microvacuole (glistening) formation in hydrophobic intraocular lenses (IOLs). Glistenings were induced in five lenses each of five different hydrophobic acrylic IOL models, using an established in vitro laboratory model: 800C (Rayner, Worthing, UK), AcrySof SN60WF (Alcon, Fort Worth, USA), Tecnis ZCB00 (Johnson & Johnson Vision, Santa Ana, USA), Vivinex XY1 (Hoya, Tokyo, Japan) and CT Lucia 611P (Zeiss, Oberkochen, Germany). We evaluated the number of microvacuoles per square millimeter (MV/mm2) in the central part of each IOL. Results were analyzed statistically, and mean glistening numbers were ranked, with the highest in the SN60WF which had 66.0 (±45.5) MVs/mm, followed by the 611P with 30.7 (±8.4) MVs/mm2. The 800C and XY1 showed comparable values of 2.0 (±3.6) and 2.7 (±2.4) MVs/mm2, respectively. ZCB00 had the lowest number with 0.9 (±0.6) MVs/mm2. This study shows that the resistance to glistening formation differs depending on the hydrophobic acrylic copolymer composition of the IOL material. Some IOLs from current clinical use are still prone to develop glistenings whereas others, including the ZCB00, 800C and XY1 show high resistance to microvacuole formation.

In vitro optical quality of monofocal aspheric toric intraocular lenses: effect of cylindrical power

2017 ◽  
Vol 38 (3) ◽  
pp. 933-941
Author(s):  
Teresa Ferrer-Blasco ◽  
Alberto Domínguez-Vicent ◽  
Santiago García-Lázaro ◽  
María Amparo Diez ◽  
José F. Alfonso ◽  
...  
Keyword(s):  
Optical Quality ◽  
Intraocular Lenses

scholarly journals Impact of Glycine Betaine on Salinity Tolerance of Stevia (Stevia rebaudiana Bertoni) under In Vitro Condition

2017 ◽  
Vol 50 (3) ◽  
pp. 95-105 ◽  
Author(s):  
V. Rameeh ◽  
M. Gerami ◽  
V. Ghasemi Omran ◽  
S. Ghavampour
Keyword(s):  
Glycine Betaine ◽  
Stevia Rebaudiana ◽  
Mean Value ◽  
Rebaudioside A ◽  
Stevia Rebaudiana Bertoni ◽  
Nacl Concentration ◽  
Salinity Levels ◽  
High Concentrations

Abstract Stevia (Stevia rebaudiana Bertoni), with great potential as a natural sweeteners source, has a high content of sweeteners, which are up to 150 times sweeter than sugar, but virtually with no calories. Stevia also suitable to be cultivated in semiarid climates and coastal areas, which are characterized by the low quality of the irrigation water. Soil salinity occupies a prominent place among the soil problems that threaten the sustainability of agriculture over a vast area in the world. Glycine betaine is an osmoprotectant, that plays an important role and accumulates rapidly in many plants during salinity or drought stress. In order to evaluation of glycine betaine amending effects on salinity stress in stevia under in vitro condition, a factorial experiment was conducted in 2015. Four NaCl levels, including 0, 50, 75 and 100 mM, along with 0, 1, 12.5, 25 and 50 mM of glycine betaine concentrations were used in Murashige and Skoog (MS) medium. The results showed that salinity levels had significant reduction effects on plant height, root length, shoot fresh weight, number of leaf, total chlorophyll, rebaudioside A and stevioside of the stevia genotype. Due to increasing of glycine betaine, levels all the traits were increased. Owing to amending effect of glycine betaine, its high concentrations made less hazarding effects of salinity on the researched traits. The highest mean value of rebaudioside A (10.62rt) and stevioside (23.38rt) determined at 50 mM of glycine betaine with 0 mM of NaCl concentration.

In vitro comparison of glistening formation among hydrophobic acrylic intraocular lenses

2002 ◽  
Vol 28 (7) ◽  
pp. 1262-1268 ◽  
Author(s):  
Ninel Z. Gregori ◽  
Terrence S. Spencer ◽  
Nick Mamalis ◽  
Randall J. Olson
Keyword(s):  
Intraocular Lenses ◽  
Hydrophobic Acrylic ◽  
In Vitro Comparison

scholarly journals Visual acuity and image quality in 5 diffractive intraocular lenses

2017 ◽  
Vol 28 (1) ◽  
pp. 36-41 ◽  
Author(s):  
Genís Cardona ◽  
Fidel Vega ◽  
Miguel A. Gil ◽  
Consuelo Varón ◽  
José A. Buil ◽  
...  
Keyword(s):  
Visual Acuity ◽  
Image Quality ◽  
Optical Quality ◽  
Intraocular Lenses ◽  
Modulation Transfer ◽  
Multifocal Intraocular Lenses ◽  
Corrected Distance Visual Acuity ◽  
Good For

Purpose: To compare objective image quality at distant, intermediate, and near foci with the corresponding visual acuity (VA) in patients symmetrically implanted with 5 different diffractive multifocal intraocular lenses (IOLs) (ReSTOR SV25T0, Tecnis ZKB00, Tecnis ZLB00, AT LISA 809, and AT LISA Tri 839MP) and a monofocal lens (Tecnis ZA9003) 3 months after cataract intervention. Methods: Objective image quality, measured as the area under the modulation transfer function curve (AMTF), was tested in vitro in an eye model. In addition, corrected distance visual acuity and distance-corrected intermediate and near visual acuities (DCIVA and DCNVA) were assessed in a group of 79 patients, randomly implanted with one of the lenses. Results: Image quality and VA at the distant focus was good for all lens designs, but was similarly compromised at the intermediate focus, where the best DCIVA corresponded to the low add ZKB00. At the near focus, the monofocal lens and the distance dominant SV25T0 had the worst AMTF values, with the ZLB00 presenting the best DCNVA. The relationship between AMTF and VA was found not to be linear, with VA being similarly good for AMTF values over a certain threshold. Conclusions: Visual acuity of pseudophakic patients reflected the optical quality of the specific IOL design within a certain range of measurements, beyond which maximum VA is limited by other ocular, optical, and neuropsychophysical factors.

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